BETI_ECO7I
ID BETI_ECO7I Reviewed; 195 AA.
AC B7NK49;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 1.
DT 25-MAY-2022, entry version 73.
DE RecName: Full=HTH-type transcriptional regulator BetI {ECO:0000255|HAMAP-Rule:MF_00768};
GN Name=betI {ECO:0000255|HAMAP-Rule:MF_00768};
GN OrderedLocusNames=ECIAI39_0373;
OS Escherichia coli O7:K1 (strain IAI39 / ExPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=585057;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IAI39 / ExPEC;
RX PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H.,
RA Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E.,
RA Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C.,
RA Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S.,
RA Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J.,
RA Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT "Organised genome dynamics in the Escherichia coli species results in
RT highly diverse adaptive paths.";
RL PLoS Genet. 5:E1000344-E1000344(2009).
CC -!- FUNCTION: Repressor involved in the biosynthesis of the osmoprotectant
CC glycine betaine. It represses transcription of the choline transporter
CC BetT and the genes of BetAB involved in the synthesis of glycine
CC betaine (By similarity). {ECO:0000250}.
CC -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via
CC choline pathway [regulation].
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DR EMBL; CU928164; CAR16513.1; -; Genomic_DNA.
DR RefSeq; WP_012602193.1; NC_011750.1.
DR RefSeq; YP_002406412.1; NC_011750.1.
DR AlphaFoldDB; B7NK49; -.
DR SMR; B7NK49; -.
DR STRING; 585057.ECIAI39_0373; -.
DR EnsemblBacteria; CAR16513; CAR16513; ECIAI39_0373.
DR KEGG; ect:ECIAI39_0373; -.
DR PATRIC; fig|585057.6.peg.399; -.
DR HOGENOM; CLU_069356_15_4_6; -.
DR OMA; DFWSSSM; -.
DR UniPathway; UPA00529; -.
DR Proteomes; UP000000749; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019285; P:glycine betaine biosynthetic process from choline; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00768; HTH_type_BetI; 1.
DR InterPro; IPR039538; BetI_C.
DR InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR InterPro; IPR017757; Tscrpt_rep_BetI.
DR Pfam; PF13977; TetR_C_6; 1.
DR Pfam; PF00440; TetR_N; 1.
DR PRINTS; PR00455; HTHTETR.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF48498; SSF48498; 1.
DR TIGRFAMs; TIGR03384; betaine_BetI; 1.
DR PROSITE; PS01081; HTH_TETR_1; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..195
FT /note="HTH-type transcriptional regulator BetI"
FT /id="PRO_1000133660"
FT DOMAIN 8..68
FT /note="HTH tetR-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00768"
FT DNA_BIND 31..50
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00768"
SQ SEQUENCE 195 AA; 21756 MW; 4880A111EF3FA3A3 CRC64;
MPKLGMQSIR RRQLIDATLE AINEVGMHDA TIAQIARRAG VSTGIISHYF RDKNGLLEAT
MRDITSQLRD AVLNRLHALP QGSAELRLQA IVGGNFDETQ VSSAAMKAWL AFWASSMHQP
MLYRLQQVSS RRLLSNLVSE FHRELPRQQA QEAGYGLAAL IDGLWLRAAL SGKPLDKPLA
HSLTRHFITQ HLPTD