SCPDL_MOUSE
ID SCPDL_MOUSE Reviewed; 429 AA.
AC Q8R127; Q3TMB9;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Saccharopine dehydrogenase-like oxidoreductase;
DE EC=1.-.-.-;
GN Name=Sccpdh;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, Corpora quadrigemina, and Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Lung, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the saccharopine dehydrogenase family.
CC {ECO:0000305}.
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DR EMBL; AK042919; BAC31405.1; -; mRNA.
DR EMBL; AK046033; BAC32578.1; -; mRNA.
DR EMBL; AK077695; BAC36962.1; -; mRNA.
DR EMBL; AK082803; BAC38628.1; -; mRNA.
DR EMBL; AK166018; BAE38523.1; -; mRNA.
DR EMBL; BC025803; AAH25803.1; -; mRNA.
DR CCDS; CCDS15563.1; -.
DR RefSeq; NP_848768.1; NM_178653.3.
DR AlphaFoldDB; Q8R127; -.
DR BioGRID; 224610; 3.
DR IntAct; Q8R127; 1.
DR MINT; Q8R127; -.
DR STRING; 10090.ENSMUSP00000040956; -.
DR iPTMnet; Q8R127; -.
DR PhosphoSitePlus; Q8R127; -.
DR SwissPalm; Q8R127; -.
DR EPD; Q8R127; -.
DR MaxQB; Q8R127; -.
DR PaxDb; Q8R127; -.
DR PeptideAtlas; Q8R127; -.
DR PRIDE; Q8R127; -.
DR ProteomicsDB; 261135; -.
DR TopDownProteomics; Q8R127; -.
DR Antibodypedia; 34722; 131 antibodies from 25 providers.
DR DNASU; 109232; -.
DR Ensembl; ENSMUST00000040538; ENSMUSP00000040956; ENSMUSG00000038936.
DR GeneID; 109232; -.
DR KEGG; mmu:109232; -.
DR UCSC; uc007dvp.1; mouse.
DR CTD; 51097; -.
DR MGI; MGI:1924486; Sccpdh.
DR VEuPathDB; HostDB:ENSMUSG00000038936; -.
DR eggNOG; KOG2733; Eukaryota.
DR GeneTree; ENSGT00390000004799; -.
DR HOGENOM; CLU_031002_1_0_1; -.
DR InParanoid; Q8R127; -.
DR OMA; KQIGHKP; -.
DR OrthoDB; 887497at2759; -.
DR PhylomeDB; Q8R127; -.
DR TreeFam; TF314904; -.
DR Reactome; R-MMU-114608; Platelet degranulation.
DR BioGRID-ORCS; 109232; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Sccpdh; mouse.
DR PRO; PR:Q8R127; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q8R127; protein.
DR Bgee; ENSMUSG00000038936; Expressed in spermatid and 234 other tissues.
DR ExpressionAtlas; Q8R127; baseline and differential.
DR Genevisible; Q8R127; MM.
DR GO; GO:0005811; C:lipid droplet; ISO:MGI.
DR GO; GO:0030496; C:midbody; ISO:MGI.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0009247; P:glycolipid biosynthetic process; IBA:GO_Central.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032095; Sacchrp_dh-like_C.
DR InterPro; IPR005097; Sacchrp_dh_NADP.
DR Pfam; PF16653; Sacchrp_dh_C; 1.
DR Pfam; PF03435; Sacchrp_dh_NADP; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 1: Evidence at protein level;
KW Acetylation; Oxidoreductase; Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q8NBX0"
FT CHAIN 2..429
FT /note="Saccharopine dehydrogenase-like oxidoreductase"
FT /id="PRO_0000212841"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q8NBX0"
FT MOD_RES 209
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AY30"
FT MOD_RES 215
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AY30"
FT MOD_RES 217
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8NBX0"
SQ SEQUENCE 429 AA; 47129 MW; FCC63118BFCEE7E4 CRC64;
MATEQRPFHL VVFGASGFTG QFVTEEVARE QIASEQSSRL PWAVAGRSKE KLQQVLEKAA
QKLGRPSLSS EVGVIICDIS NPASLDEMAK QAKLVLNCVG PYRFYGEPVV KACIENGTSC
IDICGEPQFL ELMHAKYHEK AAEKGVYIIG SSGFDSIPAD LGVLYTRNQM NGTLTAVESF
LTINTGPEGL CIHDGTWKSA IYGFGDKGSL RKLRSVSCLK PVPIVGTKLK RRWPVSYCRE
LNSYSIPFLG SDISVVKRTQ RYLHENLEDS PVQYAAYVTV GGITSVIKLM FAGLFFLFFV
KFSIGRQLLI KFPWLFSFGY FSKQGPTQKQ MDETSFTMTF FGQGYSHGTC VEKNKPNIRI
CTQVKGPEAG YVATPIAMVQ AAMTFLSDAS DLPKGGGVFT PGAAFSRTKL IDRLNKHGIE
FSVISSSEV
