ID   SCP_HHV2H               Reviewed;         112 AA.
AC   P89458;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Small capsomere-interacting protein {ECO:0000255|HAMAP-Rule:MF_04020};
GN   Name=SCP {ECO:0000255|HAMAP-Rule:MF_04020}; OrderedLocusNames=UL35;
OS   Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10315;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=1662697; DOI=10.1099/0022-1317-72-12-3057;
RA   McGeoch D.J., Cunningham C., McIntyre G., Dolan A.;
RT   "Comparative sequence analysis of the long repeat regions and adjoining
RT   parts of the long unique regions in the genomes of herpes simplex viruses
RT   types 1 and 2.";
RL   J. Gen. Virol. 72:3057-3075(1991).
RN   [2]
RP   SUBCELLULAR LOCATION.
RX   PubMed=11161269; DOI=10.1099/0022-1317-82-2-321;
RA   Yamauchi Y., Wada K., Goshima F., Takakuwa H., Daikoku T., Yamada M.,
RA   Nishiyama Y.;
RT   "The UL14 protein of herpes simplex virus type 2 translocates the minor
RT   capsid protein VP26 and the DNA cleavage and packaging UL33 protein into
RT   the nucleus of coexpressing cells.";
RL   J. Gen. Virol. 82:321-330(2001).
CC   -!- FUNCTION: Participates in the assembly of the infectious particles by
CC       decorating the outer surface of the capsid shell and thus forming a
CC       layer between the capsid and the tegument. Complexes composed of the
CC       major capsid protein and small capsomere-interacting protein/SCP
CC       assemble together in the host cytoplasm and are translocated to the
CC       nucleus, where they accumulate and participate in capsid assembly.
CC       {ECO:0000255|HAMAP-Rule:MF_04020}.
CC   -!- SUBUNIT: Interacts with the major capsid protein/MCP.
CC       {ECO:0000255|HAMAP-Rule:MF_04020}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04020}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04020}.
CC   -!- SIMILARITY: Belongs to the herpesviridae small capsomere-interacting
CC       protein family. {ECO:0000255|HAMAP-Rule:MF_04020}.
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DR   EMBL; Z86099; CAB06721.1; -; Genomic_DNA.
DR   RefSeq; YP_009137187.1; NC_001798.2.
DR   PDB; 5ZZ8; EM; 3.75 A; b/c/d/e/f/g/h/i/j/k/l/m/n/o/p=1-112.
DR   PDB; 6M6G; EM; 5.39 A; G/M/Q/T/U/V=1-112.
DR   PDB; 6M6H; EM; 4.50 A; J/K/L/M/N/O=1-112.
DR   PDBsum; 5ZZ8; -.
DR   PDBsum; 6M6G; -.
DR   PDBsum; 6M6H; -.
DR   SMR; P89458; -.
DR   PRIDE; P89458; -.
DR   DNASU; 24271457; -.
DR   GeneID; 24271457; -.
DR   KEGG; vg:24271457; -.
DR   Proteomes; UP000001874; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0016032; P:viral process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04020; HSV_SCP_alphahv; 1.
DR   InterPro; IPR007584; Herpes_UL35.
DR   Pfam; PF04496; Herpes_UL35; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Capsid protein; Host nucleus; Reference proteome; Virion.
FT   CHAIN           1..112
FT                   /note="Small capsomere-interacting protein"
FT                   /id="PRO_0000406189"
SQ   SEQUENCE   112 AA;  12134 MW;  7FE1716E04EC1DF5 CRC64;
     MAAPQFHRPS TITADNVRAL GMRGLVLATN NAQFIMDNSY PHPHGTQGAV REFLRGQAAA
     LTDLGVTHAN NTFAPQPMFA GDAAAEWLRP SFGLKRTYSP FVVRDPKTPS TP