ID   BETI_ECOL5              Reviewed;         195 AA.
AC   Q0TKV9;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 2.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=HTH-type transcriptional regulator BetI {ECO:0000255|HAMAP-Rule:MF_00768};
GN   Name=betI {ECO:0000255|HAMAP-Rule:MF_00768}; OrderedLocusNames=ECP_0388;
OS   Escherichia coli O6:K15:H31 (strain 536 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=362663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=536 / UPEC;
RX   PubMed=16879640; DOI=10.1111/j.1365-2958.2006.05255.x;
RA   Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U.,
RA   Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J.;
RT   "Role of pathogenicity island-associated integrases in the genome
RT   plasticity of uropathogenic Escherichia coli strain 536.";
RL   Mol. Microbiol. 61:584-595(2006).
CC   -!- FUNCTION: Repressor involved in the biosynthesis of the osmoprotectant
CC       glycine betaine. It represses transcription of the choline transporter
CC       BetT and the genes of BetAB involved in the synthesis of glycine
CC       betaine (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via
CC       choline pathway [regulation].
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABG68422.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000247; ABG68422.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_001298544.1; NC_008253.1.
DR   AlphaFoldDB; Q0TKV9; -.
DR   SMR; Q0TKV9; -.
DR   STRING; 362663.ECP_0388; -.
DR   EnsemblBacteria; ABG68422; ABG68422; ECP_0388.
DR   KEGG; ecp:ECP_0388; -.
DR   HOGENOM; CLU_069356_15_4_6; -.
DR   OMA; DFWSSSM; -.
DR   UniPathway; UPA00529; -.
DR   Proteomes; UP000009182; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from choline; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00768; HTH_type_BetI; 1.
DR   InterPro; IPR039538; BetI_C.
DR   InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   InterPro; IPR017757; Tscrpt_rep_BetI.
DR   Pfam; PF13977; TetR_C_6; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   TIGRFAMs; TIGR03384; betaine_BetI; 1.
DR   PROSITE; PS01081; HTH_TETR_1; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..195
FT                   /note="HTH-type transcriptional regulator BetI"
FT                   /id="PRO_0000257737"
FT   DOMAIN          8..68
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00768"
FT   DNA_BIND        31..50
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00768"
SQ   SEQUENCE   195 AA;  21765 MW;  029AA3C1EF2E7578 CRC64;
     MPKLGMQSIR RRQLIDATLE AINEVGMHDA TIAQIARRAG VSTGIISHYF RDKNGLLEAT
     MRDITSQLRD AVLNRLHALP QGSAELRLQA IVGGNFDETQ VSSAAMKAWL AFWASSMHQP
     MLYRLQQVSS RRLLSNLVSE FRRELPRQQA QEAGYGLAAL IDGLWLRAAL SGKPLDKPLA
     HSLTRHFITQ HLSTD