ID   SCP_HHV6Z               Reviewed;          89 AA.
AC   Q9WT32; Q77PU9;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   02-JUN-2021, entry version 51.
DE   RecName: Full=Small capsomere-interacting protein {ECO:0000255|HAMAP-Rule:MF_04021};
GN   Name=SCP {ECO:0000255|HAMAP-Rule:MF_04021}; Synonyms=U32;
OS   Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic
OS   virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=36351;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HST;
RX   PubMed=10482554; DOI=10.1128/jvi.73.10.8053-8063.1999;
RA   Isegawa Y., Mukai T., Nakano K., Kagawa M., Chen J., Mori Y., Sunagawa T.,
RA   Kawanishi K., Sashihara J., Hata A., Zou P., Kosuge H., Yamanishi K.;
RT   "Comparison of the complete DNA sequences of human herpesvirus 6 variants A
RT   and B.";
RL   J. Virol. 73:8053-8063(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10482553; DOI=10.1128/jvi.73.10.8040-8052.1999;
RA   Dominguez G., Dambaugh T.R., Stamey F.R., Dewhurst S., Inoue N.,
RA   Pellett P.E.;
RT   "Human herpesvirus 6B genome sequence: coding content and comparison with
RT   human herpesvirus 6A.";
RL   J. Virol. 73:8040-8052(1999).
CC   -!- FUNCTION: Participates in the assembly of the infectious particles by
CC       decorating the outer surface of the capsid shell and thus forming a
CC       layer between the capsid and the tegument. Complexes composed of the
CC       major capsid protein and small capsomere-interacting protein/SCP
CC       assemble together in the host cytoplasm and are translocated to the
CC       nucleus, where they accumulate and participate in capsid assembly.
CC       {ECO:0000255|HAMAP-Rule:MF_04021}.
CC   -!- SUBUNIT: Interacts with the major capsid protein/MCP.
CC       {ECO:0000255|HAMAP-Rule:MF_04021}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04021}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04021}.
CC   -!- SIMILARITY: Belongs to the herpesviridae small capsomere-interacting
CC       protein family. {ECO:0000255|HAMAP-Rule:MF_04021}.
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DR   EMBL; AF157706; AAD49646.1; -; Genomic_DNA.
DR   EMBL; AB021506; BAA78253.1; -; Genomic_DNA.
DR   PIR; T43992; T43992.
DR   RefSeq; NP_050213.1; NC_000898.1.
DR   PDB; 6Q1F; EM; 9.00 A; 1/2/3/4/J/K/L/M/N/O/P/Q/R/x/y/z=1-89.
DR   PDBsum; 6Q1F; -.
DR   SMR; Q9WT32; -.
DR   PRIDE; Q9WT32; -.
DR   DNASU; 1497034; -.
DR   GeneID; 1497034; -.
DR   KEGG; vg:1497034; -.
DR   Proteomes; UP000006930; Genome.
DR   Proteomes; UP000142685; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0016032; P:viral process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04021; HSV_SCP_betahv; 1.
DR   InterPro; IPR031385; HV_small_capsid.
DR   Pfam; PF17086; HV_small_capsid; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Capsid protein; Host nucleus; Reference proteome; Virion.
FT   CHAIN           1..89
FT                   /note="Small capsomere-interacting protein"
FT                   /id="PRO_0000408428"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   89 AA;  9812 MW;  33A9E8FDA08B87C7 CRC64;
     MTTIRGDDLS NQITQISGSS SKKEEEKKKQ QMLTGVLGLQ PTMANHPVLG VFLPKYAKQN
     GGNVDKTAFR LDLIRMLALH RLNTKTGSD