ID   SCRA_LIMPO              Reviewed;         918 AA.
AC   Q25390;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Alpha-scruin;
OS   Limulus polyphemus (Atlantic horseshoe crab).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Merostomata;
OC   Xiphosura; Limulidae; Limulus.
OX   NCBI_TaxID=6850;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RX   PubMed=7822422; DOI=10.1083/jcb.128.1.51;
RA   Way M., Sanders M., Garcia C., Sakai J., Matsudaira P.;
RT   "Sequence and domain organization of scruin, an actin-cross-linking protein
RT   in the acrosomal process of Limulus sperm.";
RL   J. Cell Biol. 128:51-60(1995).
CC   -!- FUNCTION: Actin bundling protein found in the acrosomal sperm process.
CC   -!- TISSUE SPECIFICITY: Sperm.
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DR   EMBL; Z38132; CAA86292.1; -; mRNA.
DR   RefSeq; NP_001301080.1; NM_001314151.1.
DR   AlphaFoldDB; Q25390; -.
DR   SMR; Q25390; -.
DR   GeneID; 106468298; -.
DR   OrthoDB; 1344273at2759; -.
DR   Gene3D; 2.120.10.80; -; 4.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   Pfam; PF01344; Kelch_1; 6.
DR   SMART; SM00612; Kelch; 11.
DR   SUPFAM; SSF117281; SSF117281; 2.
DR   PROSITE; PS50096; IQ; 1.
PE   2: Evidence at transcript level;
KW   Kelch repeat; Repeat.
FT   CHAIN           1..918
FT                   /note="Alpha-scruin"
FT                   /id="PRO_0000119143"
FT   REPEAT          82..133
FT                   /note="Kelch 1"
FT   REPEAT          134..187
FT                   /note="Kelch 2"
FT   REPEAT          188..235
FT                   /note="Kelch 3"
FT   REPEAT          237..289
FT                   /note="Kelch 4"
FT   REPEAT          291..341
FT                   /note="Kelch 5"
FT   REPEAT          342..390
FT                   /note="Kelch 6"
FT   DOMAIN          430..459
FT                   /note="IQ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   REPEAT          590..641
FT                   /note="Kelch 7"
FT   REPEAT          642..695
FT                   /note="Kelch 8"
FT   REPEAT          696..743
FT                   /note="Kelch 9"
FT   REPEAT          745..795
FT                   /note="Kelch 10"
FT   REPEAT          797..849
FT                   /note="Kelch 11"
FT   REPEAT          851..898
FT                   /note="Kelch 12"
FT   REGION          398..427
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        398..413
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   918 AA;  103617 MW;  A660DC6B96E7764F CRC64;
     MARYRKPERV TRVISGSDEY VDFKKIDEEP TDKLDPNLGI IKSMPKLEPE EINDTLLRQT
     NLRSFKPGLS AVNDLDNEST PVVLAFGGIN TARPDEYLNS SSVFVYHPDR NKWNFYTTMM
     EPRTYHAVGY FHRRVYVFGG YNPLHCRKGK MQATATTFQL TVQTKQWRKR ADMRYARAHH
     NVTVMDERIF VFGGRDSNGE ILAAVEMYEP EMDQWTTLAS IPEPMMGSAI ANNEGIIYVI
     GGVTTNKEKK PEGNLSNKIF CFDPLNNKWY RKPSLSSPRA FSAATTQNKK IWIWGGANLS
     EEGLLSSIDS IDVLDPKKGT LEHHMNFELA KHCHAVAKTG AHVFIVGGMS SVEASAIAET
     EMYDRKRNII QRCSLLPVAL TGIAVAAIPA DTGGEYYEVP TSTPSSKAKP QPGSKPTSVK
     YKKQPDIHER NEAAKKVQRR WRRYIEQKSI TKRMQQGDSS GSTMLEGNDR ISGRIRTYIS
     GYRPLPPDQD DLSKELVPVS IPFWPPDPDT TDSVFHTVRD QYRNPEEQMG FKHFYTIPRQ
     MDPNLGMLLF MDEDYQHSKK VLGLRSVESV PYYINRFQAS GTIQDNTIPV IIGTGGVDLR
     DPMNIAYGRS VFQYHPLKDR WEFFGYMPQP RNYHAAAYYR SAIYITGGYD PDVRTWGEMV
     ATKTTFVYEL ASKNWTRMGD MRCARSHHSL LVFNDVLYAI GGRDDIGRLV SSVESYDHES
     NEWTMEKSMP SPRMGMAAVA HGGYIWLLGG LTSMTTEEPP VLDDVLCYDP VFKHWVDGRP
     LRIGRAFGNA AVCDNKIWLC GGAAPSTDEN NYLVSVPAID VYDEETMEWK QKTSLGCPRH
     SAIVVALESC LYIAGGVNSH ELSATSRNEL YMVDNDTIQT VRELPIPLTG MAAVTIPPKC
     VTFRSESLSI MIRHKVTP