SCRB1_PIG
ID SCRB1_PIG Reviewed; 509 AA.
AC Q8SQC1;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Scavenger receptor class B member 1;
DE Short=SRB1;
DE AltName: Full=High density lipoprotein receptor SR-BI;
DE AltName: Full=SR-BI;
GN Name=SCARB1;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Kim J.G., Vallet J.L., Christenson R.K.;
RT "Characterization of porcine high density lipoprotein (HDL) receptor SR-
RT BI.";
RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for different ligands such as phospholipids,
CC cholesterol ester, lipoproteins, phosphatidylserine and apoptotic
CC cells. Receptor for HDL, mediating selective uptake of cholesteryl
CC ether and HDL-dependent cholesterol efflux. Also facilitates the flux
CC of free and esterified cholesterol between the cell surface and apoB-
CC containing lipoproteins and modified lipoproteins, although less
CC efficiently than HDL. May be involved in the phagocytosis of apoptotic
CC cells, via its phosphatidylserine binding activity.
CC {ECO:0000250|UniProtKB:Q8WTV0}.
CC -!- SUBUNIT: The C-terminal region binds to PDZK1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8WTV0};
CC Multi-pass membrane protein {ECO:0000250}. Membrane, caveola
CC {ECO:0000250|UniProtKB:Q61009}; Multi-pass membrane protein
CC {ECO:0000250}. Note=Predominantly localized to cholesterol and
CC sphingomyelin-enriched domains within the plasma membrane, called
CC caveolae. {ECO:0000250}.
CC -!- PTM: N-glycosylated. {ECO:0000250}.
CC -!- PTM: The six cysteines of the extracellular domain are all involved in
CC intramolecular disulfide bonds. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CD36 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF467889; AAL75567.1; -; mRNA.
DR RefSeq; NP_999132.1; NM_213967.1.
DR AlphaFoldDB; Q8SQC1; -.
DR SMR; Q8SQC1; -.
DR STRING; 9823.ENSSSCP00000010421; -.
DR PaxDb; Q8SQC1; -.
DR PeptideAtlas; Q8SQC1; -.
DR PRIDE; Q8SQC1; -.
DR Ensembl; ENSSSCT00000010699; ENSSSCP00000010421; ENSSSCG00000009759.
DR Ensembl; ENSSSCT00015105967; ENSSSCP00015044464; ENSSSCG00015078283.
DR Ensembl; ENSSSCT00025017217; ENSSSCP00025006884; ENSSSCG00025012867.
DR Ensembl; ENSSSCT00030003725; ENSSSCP00030001466; ENSSSCG00030002857.
DR Ensembl; ENSSSCT00050075288; ENSSSCP00050032476; ENSSSCG00050055165.
DR Ensembl; ENSSSCT00055002768; ENSSSCP00055002087; ENSSSCG00055001468.
DR Ensembl; ENSSSCT00070036281; ENSSSCP00070030335; ENSSSCG00070018349.
DR GeneID; 397018; -.
DR KEGG; ssc:397018; -.
DR CTD; 949; -.
DR VGNC; VGNC:92613; SCARB1.
DR eggNOG; KOG3776; Eukaryota.
DR GeneTree; ENSGT00940000153372; -.
DR InParanoid; Q8SQC1; -.
DR OMA; DENYWIN; -.
DR OrthoDB; 1106566at2759; -.
DR ChiTaRS; SCARB1; pig.
DR Proteomes; UP000008227; Chromosome 14.
DR Proteomes; UP000314985; Chromosome 14.
DR Bgee; ENSSSCG00000009759; Expressed in ovary and 45 other tissues.
DR ExpressionAtlas; Q8SQC1; baseline and differential.
DR GO; GO:0016324; C:apical plasma membrane; IDA:AgBase.
DR GO; GO:0016323; C:basolateral plasma membrane; IDA:AgBase.
DR GO; GO:0005901; C:caveola; IDA:AgBase.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:AgBase.
DR GO; GO:0070506; F:high-density lipoprotein particle receptor activity; IMP:AgBase.
DR GO; GO:0008289; F:lipid binding; IBA:GO_Central.
DR GO; GO:0030169; F:low-density lipoprotein particle binding; IBA:GO_Central.
DR GO; GO:0005044; F:scavenger receptor activity; IBA:GO_Central.
DR GO; GO:0033344; P:cholesterol efflux; IBA:GO_Central.
DR GO; GO:0070508; P:cholesterol import; IBA:GO_Central.
DR GO; GO:0034381; P:plasma lipoprotein particle clearance; IBA:GO_Central.
DR GO; GO:0043654; P:recognition of apoptotic cell; IBA:GO_Central.
DR GO; GO:0045056; P:transcytosis; IMP:AgBase.
DR InterPro; IPR005428; CD36/SCARB1/SNMP1.
DR InterPro; IPR002159; CD36_fam.
DR PANTHER; PTHR11923; PTHR11923; 1.
DR Pfam; PF01130; CD36; 1.
DR PRINTS; PR01610; CD36ANTIGEN.
DR PRINTS; PR01609; CD36FAMILY.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..509
FT /note="Scavenger receptor class B member 1"
FT /id="PRO_0000144162"
FT TOPO_DOM 1..11
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 33..439
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 440..460
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 461..509
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 102
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 108
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 173
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 212
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 255
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 310
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 330
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 383
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 251..384
FT /evidence="ECO:0000250"
SQ SEQUENCE 509 AA; 57514 MW; F7421796C391C4C1 CRC64;
MGSRSRARQV AAALGFVGLL LAALGAVMIV MVPSIIKQQV LKNVRIDPSS LSFNMWKEIP
VPFYLSVYFF DVINPNEILQ GQKPQVRERG PYVYREFRHK SNITFNDNDT VSFLEYRSYQ
FQPHKSRGLE SDYIVIPNIL VLSASVMMED RPMSLKLIMT FAFSALGERA FVNRTVGEIM
WGYEDPLIHL INKYFPNMFP FKGKFGLFAE LNNSDSGLFT VFTGVKDFSR IHLVDKWNGL
SKVNFWHSDQ CNMINGTSGQ MWAPFMTPES SLEFYSPEAC RSMKLIYKEQ GVFEGIPTFR
FVAPNTLFAN GSVYPPNEGF CPCMESGIQN VSTCRFNAPL FLSHPHFYNA DPVLAEAVSG
LHPNTEEHSL FLDIHPVTGI PMNCSVKLQL SLYIKSVKGI GQTGKIEPVV LPLLWFAESG
AMEGETLQTF YTQLVLMPKV LHYAQYVLLA LGCVLLFIPI VYQIRSQEKC YLFWSSSKKG
SKDKEAIQAY SESLMTPAPK GTVLQEARL
