ID   SCRB_LIMPO              Reviewed;         916 AA.
AC   Q25386;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Beta-scruin;
OS   Limulus polyphemus (Atlantic horseshoe crab).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Merostomata;
OC   Xiphosura; Limulidae; Limulus.
OX   NCBI_TaxID=6850;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RX   PubMed=7593276; DOI=10.1242/jcs.108.10.3155;
RA   Way M., Sanders M., Chafel M., Tu Y.H., Knight A., Matsudaira P.;
RT   "Beta-scruin, a homologue of the actin crosslinking protein scruin, is
RT   localized to the acrosomal vesicle of Limulus sperm.";
RL   J. Cell Sci. 108:3155-3162(1995).
CC   -!- FUNCTION: May have an enzymatic role. Found the acrosomal vesicle at
CC       the anterior of sperm but not in the acrosomal process.
CC   -!- TISSUE SPECIFICITY: Sperm.
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DR   EMBL; Z47541; CAA87589.1; -; mRNA.
DR   AlphaFoldDB; Q25386; -.
DR   SMR; Q25386; -.
DR   PRIDE; Q25386; -.
DR   Gene3D; 2.120.10.80; -; 4.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   Pfam; PF01344; Kelch_1; 6.
DR   SMART; SM00612; Kelch; 10.
DR   SUPFAM; SSF117281; SSF117281; 2.
PE   2: Evidence at transcript level;
KW   Kelch repeat; Repeat.
FT   CHAIN           1..916
FT                   /note="Beta-scruin"
FT                   /id="PRO_0000119144"
FT   REPEAT          82..133
FT                   /note="Kelch 1"
FT   REPEAT          134..187
FT                   /note="Kelch 2"
FT   REPEAT          188..235
FT                   /note="Kelch 3"
FT   REPEAT          237..289
FT                   /note="Kelch 4"
FT   REPEAT          291..341
FT                   /note="Kelch 5"
FT   REPEAT          342..390
FT                   /note="Kelch 6"
FT   REPEAT          586..637
FT                   /note="Kelch 7"
FT   REPEAT          638..691
FT                   /note="Kelch 8"
FT   REPEAT          692..739
FT                   /note="Kelch 9"
FT   REPEAT          741..793
FT                   /note="Kelch 10"
FT   REPEAT          795..847
FT                   /note="Kelch 11"
FT   REPEAT          849..896
FT                   /note="Kelch 12"
FT   REGION          393..426
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        393..408
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        410..425
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   916 AA;  102732 MW;  8C4C668BCF7D2200 CRC64;
     MARYRQPERL TRTISCSDDY VDLKPVNEQP SDKMDPNLGL IASMPKVDQE DRSDLQRRWR
     NLTKLKPGLS EVNELDNEST PAVLIFGGIN TARPTDYLNS ASMFLYHLDR NNWNFYGTML
     EPRNYHAAAY FHGKVYLFGG YNPLHCIKGK MQATSTTFQL TLDVKQWRRR ADMPSARAHH
     GVTIMDERIF VFGGKDSNGN IIASVEMYEP ELDQWTSLAS IPEPLMGSAV TNNEGLIYVV
     GGLTTKKEKN QEGVLSNKIY CFDPLNNKWY RKPPLPCPRA FASATTQNKK IWIWGGASLS
     EGGTLASTTS VDIWDPKKGR FEQHLIFDSP KHCLAVTKAG TQVFIIGGMS SKENSSLAEV
     QVYDRKRDIL QKCAFLPVSL TGTAAVGIPV NRSPASDITT SKTTRSGSRK TQKTLKDKQQ
     SDIHARNKAA RTIQLNYRKY HASKQRRSGI PRDALRKKIN VGEGDRVSGR IRTYITGYRP
     KAPGDDDLSK DFAPVTIPFW PPDPDTSDSV FHTVVDQFHC AKEKMQFKHF YTIPRQIDPN
     LGMLLFMDED YQHSKKVLGL RNVESTPYYM SRFHATGDIQ DTSIPVIIAI GGVDPQDPMN
     VSYGRSVFQY HPLKDRWEFF GFMSLPRNHH AAAYYRGAIY VTGGCDPHIR CWGEMVATKM
     TFVYRLSSNK WTRVADMHSA RSHHSMVVFN DSIYVIGGRD DSGRLSASVE SYVPALDEWN
     QEKPMPLPRM GMAVVSHGGY LWVMGGVTST KGGNINPPVL DDVICYDPVF KHWVSGKPLR
     IARAFGSAVV CDDKIWLCGG AAPSQDENNY LVSIPAIDVY DNEALEWIQK ATLSCPRHSS
     VVVALESCLY LIGGINSHEL SAINRNELYT TDSDTVQSIR ELPVQLTGMA AVTIPPTCVT
     FRSESLSIMI RHKVVT