ID   SCRE2_USTVR             Reviewed;         130 AA.
AC   A0A063CBJ7;
DT   03-JUL-2019, integrated into UniProtKB/Swiss-Prot.
DT   03-SEP-2014, sequence version 1.
DT   25-MAY-2022, entry version 23.
DE   RecName: Full=Secreted cysteine-rich effector 2 {ECO:0000303|PubMed:31105658};
DE   Flags: Precursor;
GN   Name=SCRE2 {ECO:0000303|PubMed:31105658}; ORFNames=UV8b_1261, UVI_02037790;
OS   Ustilaginoidea virens (Rice false smut fungus) (Villosiclava virens).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Clavicipitaceae; Ustilaginoidea.
OX   NCBI_TaxID=1159556;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UV-8b;
RX   PubMed=24846013; DOI=10.1038/ncomms4849;
RA   Zhang Y., Zhang K., Fang A., Han Y., Yang J., Xue M., Bao J., Hu D.,
RA   Zhou B., Sun X., Li S., Wen M., Yao N., Ma L.J., Liu Y., Zhang M.,
RA   Huang F., Luo C., Zhou L., Li J., Chen Z., Miao J., Wang S., Lai J.,
RA   Xu J.R., Hsiang T., Peng Y.L., Sun W.;
RT   "Specific adaptation of Ustilaginoidea virens in occupying host florets
RT   revealed by comparative and functional genomics.";
RL   Nat. Commun. 5:3849-3849(2014).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IPU010;
RX   PubMed=27151791; DOI=10.1128/genomea.00306-16;
RA   Kumagai T., Ishii T., Terai G., Umemura M., Machida M., Asai K.;
RT   "Genome sequence of Ustilaginoidea virens IPU010, a rice pathogenic fungus
RT   causing false smut.";
RL   Genome Announc. 4:0-0(2016).
RN   [3]
RP   FUNCTION, INDUCTION, SUBCELLULAR LOCATION, DOMAIN, AND DISRUPTION
RP   PHENOTYPE.
RX   PubMed=31105658; DOI=10.3389/fmicb.2019.00845;
RA   Fang A., Gao H., Zhang N., Zheng X., Qiu S., Li Y., Zhou S., Cui F.,
RA   Sun W.;
RT   "A novel effector gene SCRE2 contributes to full virulence of
RT   Ustilaginoidea virens to Rice.";
RL   Front. Microbiol. 10:845-845(2019).
CC   -!- FUNCTION: Secreted effector required for full virulence of U.virens
CC       (PubMed:31105658). Inhibits host pathogen-associated molecular pattern-
CC       triggered immunity including flg22- and chitin-induced defense gene
CC       expression and oxidative burst (PubMed:31105658).
CC       {ECO:0000269|PubMed:31105658}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:31105658}. Host cell
CC       {ECO:0000269|PubMed:31105658}. Host periplasm
CC       {ECO:0000269|PubMed:31105658}. Note=Localizes in periplasmic spaces and
CC       perhaps in multiple subcellular compartments of plant cells.
CC       {ECO:0000269|PubMed:31105658}.
CC   -!- INDUCTION: Expression is up-regulated during U.virens plant infection.
CC       {ECO:0000269|PubMed:31105658}.
CC   -!- DOMAIN: The Plant immunity suppression domain is sufficient to retain
CC       the ability to suppress immunity-associated responses.
CC       {ECO:0000269|PubMed:31105658}.
CC   -!- DISRUPTION PHENOTYPE: Greatly attenuates U.virens virulence to rice.
CC       {ECO:0000269|PubMed:31105658}.
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DR   EMBL; BBTG02000020; GAO14134.1; -; Genomic_DNA.
DR   EMBL; JHTR01000004; KDB17894.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A063CBJ7; -.
DR   EnsemblFungi; KDB17894; KDB17894; UV8b_1261.
DR   HOGENOM; CLU_1939689_0_0_1; -.
DR   Proteomes; UP000054053; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0044229; C:host cell periplasmic space; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Host periplasm; Secreted; Signal; Virulence.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..130
FT                   /note="Secreted cysteine-rich effector 2"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_5008196035"
FT   REGION          68..85
FT                   /note="Plant immunity suppression domain"
FT                   /evidence="ECO:0000269|PubMed:31105658"
SQ   SEQUENCE   130 AA;  14147 MW;  4ED6D8890B739F38 CRC64;
     MLINAARLLL PAAALVHLSL AWATSDRCNG YSSTLIQIKH AGDIYKQPSV PGLPPPGVNP
     YSLIDTLLKN GEDWCKHCAS PRVSVDAGRY KAQMDKLLSY AHPYSASSWD SVQSLGDALE
     HLCKASRKEN