SCRG1_HUMAN
ID SCRG1_HUMAN Reviewed; 98 AA.
AC O75711;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Scrapie-responsive protein 1;
DE AltName: Full=Scrapie-responsive gene 1 protein;
DE Short=ScRG-1;
DE Flags: Precursor;
GN Name=SCRG1; ORFNames=UNQ390/PRO725;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=9660755; DOI=10.1074/jbc.273.29.18015;
RA Dron M., Dandoy-Dron F., Guillo F., Benboudjema L., Hauw J.-J., Lebon P.,
RA Dormont D., Tovey M.G.;
RT "Characterization of the human analogue of a scrapie-responsive gene.";
RL J. Biol. Chem. 273:18015-18018(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP PROTEIN SEQUENCE OF 21-35.
RX PubMed=15340161; DOI=10.1110/ps.04682504;
RA Zhang Z., Henzel W.J.;
RT "Signal peptide prediction based on analysis of experimentally verified
RT cleavage sites.";
RL Protein Sci. 13:2819-2824(2004).
CC -!- INTERACTION:
CC O75711; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-10189029, EBI-744545;
CC O75711; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-10189029, EBI-18304435;
CC O75711; Q9NQG1: MANBAL; NbExp=3; IntAct=EBI-10189029, EBI-3867271;
CC O75711; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-10189029, EBI-8638294;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed abundantly in the central nervous system
CC of adult, but not at all in fetal brain. High levels of SCRG1
CC transcripts are also observed in testis and aorta.
CC -!- SIMILARITY: Belongs to the SCRG1 family. {ECO:0000305}.
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DR EMBL; AJ224677; CAA12059.1; -; mRNA.
DR EMBL; AY359040; AAQ89399.1; -; mRNA.
DR CCDS; CCDS3818.1; -.
DR RefSeq; NP_001316526.1; NM_001329597.1.
DR RefSeq; NP_009212.1; NM_007281.3.
DR AlphaFoldDB; O75711; -.
DR BioGRID; 116469; 4.
DR IntAct; O75711; 4.
DR STRING; 9606.ENSP00000296506; -.
DR GlyGen; O75711; 1 site.
DR iPTMnet; O75711; -.
DR PhosphoSitePlus; O75711; -.
DR BioMuta; SCRG1; -.
DR MassIVE; O75711; -.
DR PaxDb; O75711; -.
DR PeptideAtlas; O75711; -.
DR PRIDE; O75711; -.
DR ProteomicsDB; 50169; -.
DR Antibodypedia; 2568; 65 antibodies from 14 providers.
DR DNASU; 11341; -.
DR Ensembl; ENST00000296506.8; ENSP00000296506.2; ENSG00000164106.8.
DR GeneID; 11341; -.
DR KEGG; hsa:11341; -.
DR MANE-Select; ENST00000296506.8; ENSP00000296506.2; NM_007281.4; NP_009212.1.
DR CTD; 11341; -.
DR DisGeNET; 11341; -.
DR GeneCards; SCRG1; -.
DR HGNC; HGNC:17036; SCRG1.
DR HPA; ENSG00000164106; Tissue enhanced (brain, choroid plexus).
DR MIM; 603163; gene.
DR neXtProt; NX_O75711; -.
DR OpenTargets; ENSG00000164106; -.
DR PharmGKB; PA165664478; -.
DR VEuPathDB; HostDB:ENSG00000164106; -.
DR eggNOG; ENOG502S6ID; Eukaryota.
DR GeneTree; ENSGT00390000009191; -.
DR HOGENOM; CLU_163466_0_0_1; -.
DR InParanoid; O75711; -.
DR OMA; RNCHSLP; -.
DR OrthoDB; 1523830at2759; -.
DR PhylomeDB; O75711; -.
DR TreeFam; TF335779; -.
DR PathwayCommons; O75711; -.
DR SignaLink; O75711; -.
DR BioGRID-ORCS; 11341; 9 hits in 1062 CRISPR screens.
DR ChiTaRS; SCRG1; human.
DR GenomeRNAi; 11341; -.
DR Pharos; O75711; Tbio.
DR PRO; PR:O75711; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; O75711; protein.
DR Bgee; ENSG00000164106; Expressed in tibia and 164 other tissues.
DR ExpressionAtlas; O75711; baseline and differential.
DR Genevisible; O75711; HS.
DR GO; GO:0005615; C:extracellular space; TAS:ProtInc.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0044306; C:neuron projection terminus; IBA:GO_Central.
DR GO; GO:0007399; P:nervous system development; TAS:ProtInc.
DR InterPro; IPR028063; SCRG1.
DR PANTHER; PTHR17463; PTHR17463; 1.
DR Pfam; PF15224; SCRG1; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Glycoprotein; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000269|PubMed:15340161"
FT CHAIN 21..98
FT /note="Scrapie-responsive protein 1"
FT /id="PRO_0000022283"
FT CARBOHYD 72
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 42
FT /note="P -> L (in dbSNP:rs2306465)"
FT /id="VAR_020329"
SQ SEQUENCE 98 AA; 11081 MW; A5F1FD40BF5401C0 CRC64;
MKLMVLVFTI GLTLLLGVQA MPANRLSCYR KILKDHNCHN LPEGVADLTQ IDVNVQDHFW
DGKGCEMICY CNFSELLCCP KDVFFGPKIS FVIPCNNQ
