SCRG1_MOUSE
ID SCRG1_MOUSE Reviewed; 98 AA.
AC O88745;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Scrapie-responsive protein 1;
DE AltName: Full=Scrapie-responsive gene 1 protein;
DE Short=ScRG-1;
DE Flags: Precursor;
GN Name=Scrg1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=9516475; DOI=10.1074/jbc.273.13.7691;
RA Dandoy-Dron F., Guillo F., Benboudjema L., Deslys J.-P., Lasmesas C.,
RA Dormont D., Tovey M.G., Dron M.;
RT "Gene expression in scrapie. Cloning of a new scrapie-responsive gene and
RT the identification of increased levels of seven other mRNA transcripts.";
RL J. Biol. Chem. 273:7691-7697(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6N; TISSUE=Liver;
RX PubMed=9660755; DOI=10.1074/jbc.273.29.18015;
RA Dron M., Dandoy-Dron F., Guillo F., Benboudjema L., Hauw J.-J., Lebon P.,
RA Dormont D., Tovey M.G.;
RT "Characterization of the human analogue of a scrapie-responsive gene.";
RL J. Biol. Chem. 273:18015-18018(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed at higher levels in the brains of
CC scrapie-infected animals.
CC -!- SIMILARITY: Belongs to the SCRG1 family. {ECO:0000305}.
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DR EMBL; AJ223206; CAA11181.1; -; mRNA.
DR EMBL; AJ251216; CAC24847.1; -; Genomic_DNA.
DR EMBL; BC058532; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS40342.1; -.
DR RefSeq; NP_033162.1; NM_009136.3.
DR RefSeq; XP_017168111.1; XM_017312622.1.
DR AlphaFoldDB; O88745; -.
DR BioGRID; 203111; 2.
DR STRING; 10090.ENSMUSP00000034023; -.
DR GlyGen; O88745; 1 site.
DR PhosphoSitePlus; O88745; -.
DR PaxDb; O88745; -.
DR PeptideAtlas; O88745; -.
DR PRIDE; O88745; -.
DR ProteomicsDB; 261136; -.
DR Antibodypedia; 2568; 65 antibodies from 14 providers.
DR Ensembl; ENSMUST00000034023; ENSMUSP00000034023; ENSMUSG00000031610.
DR GeneID; 20284; -.
DR KEGG; mmu:20284; -.
DR UCSC; uc009lst.1; mouse.
DR CTD; 11341; -.
DR MGI; MGI:1328308; Scrg1.
DR VEuPathDB; HostDB:ENSMUSG00000031610; -.
DR eggNOG; ENOG502S6ID; Eukaryota.
DR GeneTree; ENSGT00390000009191; -.
DR HOGENOM; CLU_163466_0_0_1; -.
DR InParanoid; O88745; -.
DR OMA; RNCHSLP; -.
DR OrthoDB; 1523830at2759; -.
DR PhylomeDB; O88745; -.
DR TreeFam; TF335779; -.
DR BioGRID-ORCS; 20284; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Scrg1; mouse.
DR PRO; PR:O88745; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; O88745; protein.
DR Bgee; ENSMUSG00000031610; Expressed in granulocyte and 118 other tissues.
DR ExpressionAtlas; O88745; baseline and differential.
DR Genevisible; O88745; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IDA:MGI.
DR GO; GO:0044306; C:neuron projection terminus; IDA:MGI.
DR GO; GO:0097168; P:mesenchymal stem cell proliferation; IEA:Ensembl.
DR InterPro; IPR028063; SCRG1.
DR PANTHER; PTHR17463; PTHR17463; 1.
DR Pfam; PF15224; SCRG1; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..98
FT /note="Scrapie-responsive protein 1"
FT /id="PRO_0000022284"
FT CARBOHYD 72
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 98 AA; 11173 MW; 71A6AE456F0C55D6 CRC64;
MMKSVVLVIL GLTLLLETQA MPSSRLSCYR KLLKDRNCHN LPEGRADLKL IDANVQHHFW
DGKGCEMICY CNFSELLCCP KDVFFGPKIS FVIPCNNH
