SCRK1_ARATH
ID SCRK1_ARATH Reviewed; 325 AA.
AC Q9SID0; Q94F01;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Probable fructokinase-1;
DE EC=2.7.1.4;
GN OrderedLocusNames=At2g31390 {ECO:0000312|Araport:AT2G31390};
GN ORFNames=T28P16.12 {ECO:0000312|EMBL:AAD26480.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play an important role in maintaining the flux of carbon
CC towards starch formation. {ECO:0000250|UniProtKB:Q6XZ79}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+);
CC Xref=Rhea:RHEA:16125, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:37721, ChEBI:CHEBI:61527, ChEBI:CHEBI:456216; EC=2.7.1.4;
CC -!- PATHWAY: Glycan biosynthesis; starch biosynthesis.
CC -!- SIMILARITY: Belongs to the carbohydrate kinase PfkB family.
CC {ECO:0000305}.
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DR EMBL; AC007169; AAD26480.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC08541.1; -; Genomic_DNA.
DR EMBL; AY091312; AAM14251.1; -; mRNA.
DR EMBL; AF387001; AAK62446.1; -; mRNA.
DR EMBL; AY128713; AAM91113.1; -; mRNA.
DR EMBL; AY074365; AAL67061.1; -; mRNA.
DR EMBL; AY085748; AAM62966.1; -; mRNA.
DR PIR; B84720; B84720.
DR RefSeq; NP_180697.1; NM_128696.4.
DR AlphaFoldDB; Q9SID0; -.
DR SMR; Q9SID0; -.
DR BioGRID; 3044; 12.
DR STRING; 3702.AT2G31390.1; -.
DR iPTMnet; Q9SID0; -.
DR SwissPalm; Q9SID0; -.
DR PaxDb; Q9SID0; -.
DR PRIDE; Q9SID0; -.
DR ProteomicsDB; 232772; -.
DR EnsemblPlants; AT2G31390.1; AT2G31390.1; AT2G31390.
DR GeneID; 817697; -.
DR Gramene; AT2G31390.1; AT2G31390.1; AT2G31390.
DR KEGG; ath:AT2G31390; -.
DR Araport; AT2G31390; -.
DR TAIR; locus:2061320; AT2G31390.
DR eggNOG; KOG2855; Eukaryota.
DR HOGENOM; CLU_027634_6_1_1; -.
DR InParanoid; Q9SID0; -.
DR OMA; PPDYFFI; -.
DR OrthoDB; 918144at2759; -.
DR PhylomeDB; Q9SID0; -.
DR BioCyc; ARA:AT2G31390-MON; -.
DR BRENDA; 2.7.1.4; 399.
DR UniPathway; UPA00152; -.
DR PRO; PR:Q9SID0; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9SID0; baseline and differential.
DR Genevisible; Q9SID0; AT.
DR GO; GO:0005829; C:cytosol; IDA:TAIR.
DR GO; GO:0005777; C:peroxisome; HDA:TAIR.
DR GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008865; F:fructokinase activity; IDA:TAIR.
DR GO; GO:0006000; P:fructose metabolic process; IDA:TAIR.
DR GO; GO:0019252; P:starch biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.1190.20; -; 1.
DR InterPro; IPR002173; Carboh/pur_kinase_PfkB_CS.
DR InterPro; IPR011611; PfkB_dom.
DR InterPro; IPR002139; Ribo/fructo_kinase.
DR InterPro; IPR029056; Ribokinase-like.
DR Pfam; PF00294; PfkB; 1.
DR PRINTS; PR00990; RIBOKINASE.
DR SUPFAM; SSF53613; SSF53613; 1.
DR PROSITE; PS00583; PFKB_KINASES_1; 1.
DR PROSITE; PS00584; PFKB_KINASES_2; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Carbohydrate metabolism; Kinase; Nucleotide-binding;
KW Reference proteome; Transferase.
FT CHAIN 1..325
FT /note="Probable fructokinase-1"
FT /id="PRO_0000237601"
FT CONFLICT 113
FT /note="R -> H (in Ref. 3; AAK62446/AAM91113)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 325 AA; 35275 MW; 5F15F105F2F2E158 CRC64;
MASNGDKGLI VSFGEMLIDF VPTESGVSLA EAPGFLKAPG GAPANVAIAV SRLGGRSAFV
GKLGDDEFGH MLAGILRKNG VDDQGINFDT GARTALAFVT LRADGDREFM FYRNPSADML
LRPDELNLDL IRSAKVFHYG SISLIVEPCR SAHLKAMEVA KEAGALLSYD PNLREPLWPS
KEEAKTQIMS IWDKAEIIKV SDVELEFLTG SNKIDDETAL TLWHPNLKLL LVTLGEKGCR
YYTKTFKGAV DPFHVNAVDT TGAGDSFVGA LLNQIVDDRS VLEDEERLRK VLRFANACGA
ITTTKKGAIP ALPSDAEVRS FLEKK
