SCRK4_ARATH
ID SCRK4_ARATH Reviewed; 326 AA.
AC Q9M1B9; Q0IGJ2; Q8LCW0;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Probable fructokinase-4;
DE EC=2.7.1.4;
GN OrderedLocusNames=At3g59480 {ECO:0000312|Araport:AT3G59480};
GN ORFNames=T16L24.30 {ECO:0000312|EMBL:CAB75445.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play an important role in maintaining the flux of carbon
CC towards starch formation. {ECO:0000250|UniProtKB:Q6XZ79}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+);
CC Xref=Rhea:RHEA:16125, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:37721, ChEBI:CHEBI:61527, ChEBI:CHEBI:456216; EC=2.7.1.4;
CC -!- PATHWAY: Glycan biosynthesis; starch biosynthesis.
CC -!- SIMILARITY: Belongs to the carbohydrate kinase PfkB family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL138659; CAB75445.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE79930.1; -; Genomic_DNA.
DR EMBL; BT028928; ABI49475.1; -; mRNA.
DR EMBL; AY086378; AAM64445.1; -; mRNA.
DR PIR; T49289; T49289.
DR RefSeq; NP_191507.1; NM_115810.4.
DR AlphaFoldDB; Q9M1B9; -.
DR SMR; Q9M1B9; -.
DR BioGRID; 10432; 4.
DR STRING; 3702.AT3G59480.1; -.
DR PaxDb; Q9M1B9; -.
DR PRIDE; Q9M1B9; -.
DR ProteomicsDB; 232774; -.
DR EnsemblPlants; AT3G59480.1; AT3G59480.1; AT3G59480.
DR GeneID; 825117; -.
DR Gramene; AT3G59480.1; AT3G59480.1; AT3G59480.
DR KEGG; ath:AT3G59480; -.
DR Araport; AT3G59480; -.
DR TAIR; locus:2097553; AT3G59480.
DR eggNOG; KOG2855; Eukaryota.
DR HOGENOM; CLU_027634_6_1_1; -.
DR InParanoid; Q9M1B9; -.
DR OMA; GAWPEYP; -.
DR OrthoDB; 918144at2759; -.
DR PhylomeDB; Q9M1B9; -.
DR BioCyc; ARA:AT3G59480-MON; -.
DR BRENDA; 2.7.1.4; 399.
DR UniPathway; UPA00152; -.
DR PRO; PR:Q9M1B9; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9M1B9; baseline and differential.
DR Genevisible; Q9M1B9; AT.
DR GO; GO:0005829; C:cytosol; IDA:TAIR.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008865; F:fructokinase activity; IDA:TAIR.
DR GO; GO:0006000; P:fructose metabolic process; IDA:TAIR.
DR GO; GO:0019252; P:starch biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.1190.20; -; 1.
DR InterPro; IPR002173; Carboh/pur_kinase_PfkB_CS.
DR InterPro; IPR011611; PfkB_dom.
DR InterPro; IPR002139; Ribo/fructo_kinase.
DR InterPro; IPR029056; Ribokinase-like.
DR Pfam; PF00294; PfkB; 1.
DR PRINTS; PR00990; RIBOKINASE.
DR SUPFAM; SSF53613; SSF53613; 1.
DR PROSITE; PS00583; PFKB_KINASES_1; 1.
DR PROSITE; PS00584; PFKB_KINASES_2; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Carbohydrate metabolism; Kinase; Nucleotide-binding;
KW Reference proteome; Transferase.
FT CHAIN 1..326
FT /note="Probable fructokinase-4"
FT /id="PRO_0000237604"
FT CONFLICT 241
FT /note="R -> S (in Ref. 4; AAM64445)"
FT /evidence="ECO:0000305"
FT CONFLICT 295
FT /note="L -> F (in Ref. 4; AAM64445)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 326 AA; 35044 MW; 377D0FE05914DCE0 CRC64;
MAASNGEKSL IVSFGEMLID FVPTVSGVSL ADAPGFIKAP GGAPANVAIA ISRLGGRAAF
VGKLGDDEFG HMLAGILKQN GVSAEGINFD TGARTALAFV TLRSDGEREF MFYRNPSADM
LLRPDELNLD VIRSAKVFHY GSISLIVEPC RSAHLKAMEV AKEAGALLSY DPNLRLPLWP
SKEEAQKQIL SIWDKAEVIK VSDEELMFLT GSDKVDDETA LSLWHSNLKL LLVTLGEKGC
RYYTKSFRGS VDPFHVDAVD TTGAGDSFVG ALLCKIVDDR AVLEDEARLR EVLRLANACG
AITTTKKGAI PALPTESEVQ SLLKGN
