ID   SCRKL_DICDI             Reviewed;         355 AA.
AC   Q54D80;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Uncharacterized sugar kinase;
DE            EC=2.7.1.-;
GN   ORFNames=DDB_G0292440;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SIMILARITY: Belongs to the carbohydrate kinase PfkB family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000190; EAL61199.1; -; Genomic_DNA.
DR   RefSeq; XP_629616.1; XM_629614.1.
DR   AlphaFoldDB; Q54D80; -.
DR   SMR; Q54D80; -.
DR   PaxDb; Q54D80; -.
DR   EnsemblProtists; EAL61199; EAL61199; DDB_G0292440.
DR   GeneID; 8628679; -.
DR   KEGG; ddi:DDB_G0292440; -.
DR   dictyBase; DDB_G0292440; -.
DR   eggNOG; ENOG502RCI5; Eukaryota.
DR   HOGENOM; CLU_781737_0_0_1; -.
DR   InParanoid; Q54D80; -.
DR   OMA; KERTMFG; -.
DR   Reactome; R-DDI-70350; Fructose catabolism.
DR   PRO; PR:Q54D80; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004454; F:ketohexokinase activity; IBA:GO_Central.
DR   GO; GO:0006000; P:fructose metabolic process; IBA:GO_Central.
DR   GO; GO:0070873; P:regulation of glycogen metabolic process; IBA:GO_Central.
DR   GO; GO:0009750; P:response to fructose; IBA:GO_Central.
DR   GO; GO:0009749; P:response to glucose; IBA:GO_Central.
DR   GO; GO:0032868; P:response to insulin; IBA:GO_Central.
DR   GO; GO:0009744; P:response to sucrose; IBA:GO_Central.
DR   GO; GO:0010043; P:response to zinc ion; IBA:GO_Central.
DR   Gene3D; 3.40.1190.20; -; 1.
DR   InterPro; IPR002173; Carboh/pur_kinase_PfkB_CS.
DR   InterPro; IPR011611; PfkB_dom.
DR   InterPro; IPR029056; Ribokinase-like.
DR   Pfam; PF00294; PfkB; 1.
DR   SUPFAM; SSF53613; SSF53613; 1.
DR   PROSITE; PS00584; PFKB_KINASES_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Carbohydrate metabolism; Kinase; Nucleotide-binding;
KW   Reference proteome; Transferase.
FT   CHAIN           1..355
FT                   /note="Uncharacterized sugar kinase"
FT                   /id="PRO_0000327984"
SQ   SEQUENCE   355 AA;  40127 MW;  DE8A8BF383094445 CRC64;
     MTIQIFGTVC IDKVRKIEEF PKSLGTYTPV ISEQILLGGE ASNTFVCINE WVEKGQESIK
     LIVPPLVDDL NGKFIINKLN QSTGKTSDKN VIFTQIQEIN NNNENNYLKY TPITDIYVCN
     KKERTMFGIG FPEIDQYMVQ CKEIKEKILN VDLQFGPNHW ISLDANYPLI NREVIKKSII
     TNTNLYIMDQ ELDTVVDELS LENTSIEHTS NLIFQSSSDH FGNKDGPIKE FFNIMNQWFQ
     KDNGIFKKFL FILTDSKNGF GIGGTWNNEW IEPYWFTPSA IPSDKVVDTT GAGDSFRAGL
     IFSLVHKNQS LSDSLEFASA CGALNCLSIG GCSSTPTLNS INQFLKLNNK NQMFL