ID   SCRK_ECOLX              Reviewed;         307 AA.
AC   P40713;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   20-JUN-2002, sequence version 2.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Fructokinase;
DE            EC=2.7.1.4;
GN   Name=cscK;
OS   Escherichia coli.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=EC3132;
RA   Bockmann J.;
RL   Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+);
CC         Xref=Rhea:RHEA:16125, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:37721, ChEBI:CHEBI:61527, ChEBI:CHEBI:456216; EC=2.7.1.4;
CC   -!- SIMILARITY: Belongs to the carbohydrate kinase PfkB family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X81461; CAA57218.2; -; Genomic_DNA.
DR   PIR; S52161; S52161.
DR   RefSeq; WP_001274888.1; NZ_UGEV01000002.1.
DR   AlphaFoldDB; P40713; -.
DR   SMR; P40713; -.
DR   STRING; 585034.ECIAI1_2427; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008865; F:fructokinase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.1190.20; -; 1.
DR   InterPro; IPR002173; Carboh/pur_kinase_PfkB_CS.
DR   InterPro; IPR011611; PfkB_dom.
DR   InterPro; IPR002139; Ribo/fructo_kinase.
DR   InterPro; IPR029056; Ribokinase-like.
DR   Pfam; PF00294; PfkB; 1.
DR   PRINTS; PR00990; RIBOKINASE.
DR   SUPFAM; SSF53613; SSF53613; 1.
DR   PROSITE; PS00583; PFKB_KINASES_1; 1.
DR   PROSITE; PS00584; PFKB_KINASES_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Carbohydrate metabolism; Kinase; Nucleotide-binding;
KW   Transferase.
FT   CHAIN           1..307
FT                   /note="Fructokinase"
FT                   /id="PRO_0000080134"
SQ   SEQUENCE   307 AA;  33393 MW;  AFA2327035956993 CRC64;
     MSAKVWVLGD AVVDLLPESD GRLLPCPGGA PANVAVGIAR LGGTSGFIGR VGDDPFGALM
     QRTLLTEGVD ITYLKQDEWH RTSTVLVDLN DQGERSFTFM VRPSADLFLE TTDLPCWRHG
     EWLHLCSIAL SAEPSRTSAF TAMTAIRHAG GFVSFDPNIR EDLWQDEHLL RLCLRQALQL
     ADVVKLSEEE WRLISGKTQN DRDICALAKE YEIAMLLVTK GAEGVVVCYR GQVHHFAGMS
     VNCVDSTGAG DAFVAGLLTG LSSTGLSTDE REMRRIIDLA QRCGALAVTA KGAMTALPCR
     QELESEK