ID   SCRK_KLEPN              Reviewed;         307 AA.
AC   P26420;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Fructokinase {ECO:0000303|PubMed:1809835};
DE            EC=2.7.1.4 {ECO:0000269|PubMed:1809835};
GN   Name=scrK;
OS   Klebsiella pneumoniae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=573;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND CATALYTIC ACTIVITY.
RC   STRAIN=1033-5P14 / KAY2026;
RX   PubMed=1809835; DOI=10.1111/j.1365-2958.1991.tb01851.x;
RA   Aulkemeyer P., Ebner R., Heilenmann G., Jahreis K., Schmid K., Wrieden S.,
RA   Lengeler J.W.;
RT   "Molecular analysis of two fructokinases involved in sucrose metabolism of
RT   enteric bacteria.";
RL   Mol. Microbiol. 5:2913-2922(1991).
CC   -!- FUNCTION: Involved in sucrose metabolism. {ECO:0000269|PubMed:1809835}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+);
CC         Xref=Rhea:RHEA:16125, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:37721, ChEBI:CHEBI:61527, ChEBI:CHEBI:456216; EC=2.7.1.4;
CC         Evidence={ECO:0000269|PubMed:1809835};
CC   -!- SIMILARITY: Belongs to the carbohydrate kinase PfkB family.
CC       {ECO:0000305}.
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DR   EMBL; X61004; CAA43322.1; -; Genomic_DNA.
DR   PIR; S18523; S18523.
DR   AlphaFoldDB; P26420; -.
DR   SMR; P26420; -.
DR   BioCyc; MetaCyc:MON-12630; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008865; F:fructokinase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.1190.20; -; 1.
DR   InterPro; IPR002173; Carboh/pur_kinase_PfkB_CS.
DR   InterPro; IPR011611; PfkB_dom.
DR   InterPro; IPR002139; Ribo/fructo_kinase.
DR   InterPro; IPR029056; Ribokinase-like.
DR   Pfam; PF00294; PfkB; 1.
DR   PRINTS; PR00990; RIBOKINASE.
DR   SUPFAM; SSF53613; SSF53613; 1.
DR   PROSITE; PS00583; PFKB_KINASES_1; 1.
DR   PROSITE; PS00584; PFKB_KINASES_2; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Carbohydrate metabolism; Kinase; Nucleotide-binding;
KW   Transferase.
FT   CHAIN           1..307
FT                   /note="Fructokinase"
FT                   /id="PRO_0000080135"
SQ   SEQUENCE   307 AA;  32344 MW;  F8CB20B234B262FA CRC64;
     MNGKIWVLGD AVVDLLPDGE GRLLQCPGGA PANVAVGVAR LGGDSGFIGR VGDDPFGRFM
     RHTLAQEQVD VNYMRLDAAQ RTSTVVVDLD SHGERTFTFM VRPSADLFLQ PEDLPPFAAG
     QWLHVCSIAL SAEPSRSTTF AALEAIKRAG GYVSFDPNIR SDLWQDPQDL RDCLDRALAL
     ADAIKLSEEE LAFISGSDDI VSGIARLNAR FQPTLLLVTQ GKAGVQAALR GQVSHFPARP
     VVAVDTTGAG DAFVAGLLAG LAAHGIPDNL AALAPDLALA QTCGALATTA KGAMTALPYK
     DDLQRSL