ID   SCRK_SOLTU              Reviewed;         319 AA.
AC   P37829;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Fructokinase;
DE            EC=2.7.1.4;
OS   Solanum tuberosum (Potato).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX   NCBI_TaxID=4113;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Record;
RX   PubMed=8278523; DOI=10.1104/pp.102.3.1043;
RA   Smith S.B., Taylor M.A., Burch L.R., Davies H.V.;
RT   "Primary structure and characterization of a cDNA clone of fructokinase
RT   from potato (Solanum tuberosum L. cv record).";
RL   Plant Physiol. 102:1043-1043(1993).
CC   -!- FUNCTION: May play an important role in maintaining the flux of carbon
CC       towards starch formation.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+);
CC         Xref=Rhea:RHEA:16125, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:37721, ChEBI:CHEBI:61527, ChEBI:CHEBI:456216; EC=2.7.1.4;
CC   -!- PATHWAY: Glycan biosynthesis; starch biosynthesis.
CC   -!- TISSUE SPECIFICITY: Expressed in swelling stolons and, at higher
CC       levels, in developing tubers. Low levels found in leaves and stems from
CC       tuberizing plants.
CC   -!- SIMILARITY: Belongs to the carbohydrate kinase PfkB family.
CC       {ECO:0000305}.
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DR   EMBL; Z12823; CAA78283.1; -; mRNA.
DR   PIR; S39997; S39997.
DR   AlphaFoldDB; P37829; -.
DR   SMR; P37829; -.
DR   STRING; 4113.PGSC0003DMT400069198; -.
DR   PRIDE; P37829; -.
DR   ProMEX; P37829; -.
DR   eggNOG; KOG2855; Eukaryota.
DR   BRENDA; 2.7.1.4; 5757.
DR   SABIO-RK; P37829; -.
DR   UniPathway; UPA00152; -.
DR   Proteomes; UP000011115; Unassembled WGS sequence.
DR   ExpressionAtlas; P37829; baseline.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008865; F:fructokinase activity; IBA:GO_Central.
DR   GO; GO:0006000; P:fructose metabolic process; IBA:GO_Central.
DR   GO; GO:0019252; P:starch biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.1190.20; -; 1.
DR   InterPro; IPR002173; Carboh/pur_kinase_PfkB_CS.
DR   InterPro; IPR011611; PfkB_dom.
DR   InterPro; IPR002139; Ribo/fructo_kinase.
DR   InterPro; IPR029056; Ribokinase-like.
DR   Pfam; PF00294; PfkB; 1.
DR   PRINTS; PR00990; RIBOKINASE.
DR   SUPFAM; SSF53613; SSF53613; 1.
DR   PROSITE; PS00583; PFKB_KINASES_1; 1.
DR   PROSITE; PS00584; PFKB_KINASES_2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Carbohydrate metabolism; Kinase; Nucleotide-binding;
KW   Reference proteome; Transferase.
FT   CHAIN           1..319
FT                   /note="Fructokinase"
FT                   /id="PRO_0000080139"
SQ   SEQUENCE   319 AA;  33765 MW;  D7368FB02CF938F2 CRC64;
     MAVNGSALSS GLIVSFGEML IDFVPTVSGV SLAEAPGFLK APGGAPANVA IAVTRLGGKS
     AFVGKLGDDE FGHMLAGILK TNGVQADGIN FDKGARTALA FVTLRADGER EFMFYRNPSA
     DMLLTPDELN LDLIRSAKVF HYGSISLIVE PCRSAHLKAM EVAKEAGALL SYDPNLRLPL
     WSSEAEARKA IKVSDVELEF LTGSDKIDDE SAMSLWHPNL KLLLVTLGEK GCNYYTKKFH
     GSVGGFHVKT VDTTGAGDSF VGALLTKIVD DQAILEDEAR LKEVLRFSCA CGAITTTKKG
     AIPALPTESE ALTLLKGGA