ID   SCRL1_ORYSJ             Reviewed;        2097 AA.
AC   Q84TX2;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 2.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=SCAR-like protein 1;
GN   OrderedLocusNames=Os03g0816900, Os03g0817000, LOC_Os03g60240;
GN   ORFNames=OSJNBa0094J08.20;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16109971; DOI=10.1101/gr.3869505;
RG   The rice chromosome 3 sequencing consortium;
RA   Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B.,
RA   Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T.,
RA   Fadrosh D., Bera J., Weaver B., Jin S., Johri S., Reardon M., Webb K.,
RA   Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T.,
RA   Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R.,
RA   Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J.,
RA   Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S.,
RA   Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M.,
RA   Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M.,
RA   Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L.,
RA   O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R.,
RA   Jin W., Lee H.R., Jiang J., Jackson S.;
RT   "Sequence, annotation, and analysis of synteny between rice chromosome 3
RT   and diverged grass species.";
RL   Genome Res. 15:1284-1291(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 32-1186 AND 1665-2097.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
CC   -!- FUNCTION: Involved in regulation of actin and microtubule organization.
CC       Part of a WAVE complex that activates the Arp2/3 complex (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SCAR/WAVE family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAO60018.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC133007; AAO60018.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AP014959; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK066412; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AK104998; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; XP_015631167.1; XM_015775681.1.
DR   AlphaFoldDB; Q84TX2; -.
DR   STRING; 4530.OS03T0816900-01; -.
DR   PaxDb; Q84TX2; -.
DR   PRIDE; Q84TX2; -.
DR   GeneID; 4334569; -.
DR   KEGG; osa:4334569; -.
DR   eggNOG; ENOG502QTI6; Eukaryota.
DR   InParanoid; Q84TX2; -.
DR   OrthoDB; 594491at2759; -.
DR   Proteomes; UP000000763; Chromosome 3.
DR   Proteomes; UP000059680; Chromosome 3.
DR   Genevisible; Q84TX2; OS.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0071933; F:Arp2/3 complex binding; IBA:GO_Central.
DR   GO; GO:0034237; F:protein kinase A regulatory subunit binding; IBA:GO_Central.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:2000601; P:positive regulation of Arp2/3 complex-mediated actin nucleation; IBA:GO_Central.
DR   InterPro; IPR028288; SCAR/WAVE_fam.
DR   InterPro; IPR003124; WH2_dom.
DR   PANTHER; PTHR12902; PTHR12902; 1.
DR   PROSITE; PS51082; WH2; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..2097
FT                   /note="SCAR-like protein 1"
FT                   /id="PRO_0000189009"
FT   DOMAIN          2028..2046
FT                   /note="WH2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00406"
FT   REGION          205..227
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          544..565
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1443..1467
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1588..1616
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1730..1802
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1820..1842
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1893..1944
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        213..227
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        546..563
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1598..1616
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1766..1791
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1905..1923
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        1084
FT                   /note="D -> Y (in Ref. 4; AK066412)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2060
FT                   /note="A -> V (in Ref. 4; AK104998)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   2097 AA;  230573 MW;  1936DCEC24C6F007 CRC64;
     MIRYQIRNEY GLSDPELYAP GEKDDPEALL EGVAMAGLVG VLRQLGDLAE FAAEIFHDLH
     EDVMATASRG HGLMLRLRQL EAEFPAVEKA IISQSDHSNY PHDDGVEWHT NLQIDQNMIT
     QGDMPRFILD SYEECRGPPR LFTLDKFDVA GAGASLKRYS DPSFFKTEHS SDMIETDAVI
     EKKPRKIKKK ALRWRKGETL ESLLIANSES HTTSKDRSSR KVPPRTTKLK YRYPRESDHK
     NISRICREHL QEIISSQQKI FSNYSSRYYH PKFRLTESSE TASSFGEIDN FSARAQSSAK
     LELTKVVPIN EFDTKGIAPT HINGSDCLEA LEADDRQLQA TQHEPDKVED VCKRSLVEQN
     AMLSNSDRMQ SVQEENLLSA MVPADQNDDR CRPDDTGSDQ ENFVDALNNM ESEGEAHAEM
     KIKKDPGAKM ELDELNFHRD EGENERHTEF SELGHVIDSS PWLNDSYNGG EPNHAISSNT
     NFSGVDCTND EEPSNDVDLM EMDVSSSSSV FSDDNDVFRT NGNMNGFQQY QEASLSNDHH
     AVIAHSSDKQ SSQKSSGLDG SSIESNDFIE KPFHSLEDDK NFAPDGTSVI LGRPNDVSQC
     EEEIEVGNAD DSLLQPTISN QEVHRSNNQL EGVAMHASIS SGKVASFPDM DPGMCTKDLE
     LDNVLVPKET VANTPPTGLG TDHIHEHVDE LDSGVAPINS SIQSDSTYES DDDDMAEDLN
     SLPEDDLYKH DVEDLYKHVL EDDGIIALGK GPCSTRANMH QEDPMEVSDV RGDFSNGQEL
     PVLTETASPQ GELVGGGELP LLTETASPQG GEEDLADEVV VISSRDLNDE KKPSLAEVPL
     ACGDASLLDS SASCLEHDES TETGEIAKSD EVLVNVEVAE ESITGRFTDD MTPFQEDLPD
     GAKYSEDAEF LANPRVDNSR HDVQLQSSSP CREELETVKA PCENLCALDE SREHIFEKSV
     LQINNLPQHI ETKNTGEACS DIDDIQHLSA LHCPKNPVCQ EELPDETNLS ADVQYHCDVE
     KGGAVILNSK MVEEQPENID LVREPRAQDS FGTNPFMDPG YKANHALADP CPSYQPCFSE
     EEQDFISELL IPHGNMGIED LNPVPVADSL WEPATPPDEV PLPSEVMTEE DFRSFCHEYH
     EMDLTATPES IDDKPASDSN VVSSSLVTSE SEFLYCVSAV RTGVDQEESR DAPDDTLMHF
     SAKADPDDKA ANSDLKSDEP FIDEKIHELG VPSVPMELEV EQHALHEVDS HGDSQLLDND
     MIDETCSSPS GNSIAVKDKQ ETCANLVSRA FINERTDELE VPVSNSVLLE PSEEVHDSDE
     YNYQDVPWSS TDEGRDEVDA HPLSKRIQTQ GSEALVLGEL DSRAVPSCSV NEMADHVDAP
     PLSTVLEAEQ EPEDCISGEH NSQVTKSSLV DEKIGELDDA SPLSNTLLAE MEREVCVPGK
     SASQIASCSP TPSNEKIDEL NAPPLSSSGL IELESEDSVS GDLDSQIIPC SSPNDKTNEP
     DGATSTHVLP VELEQEVCSF PELDSLVAPC SLNDDKVCEL DEPPCKQLES ENGSYCLPQV
     DCQIEPCYSE SVVLSEASTM SSANAMPSTE ETYRLSSPVP PPNEPFSNVS YEDPQKPPPL
     PPLLWRLGKP RLGIASTKGH MLEPERGKGP VLHTSDAGMD NMPGCLSGMT ESIEPVSSQE
     IKERHLDPIL DNNERGVEFR RLATPPTAND VAVTEHVQLF SDACENIKHQ ERVSSSETEA
     EEHQNGTGIT DVMDSHPPKP LFLVPSISQQ GLQGSVFPSD TSDNGEHSSY TSRAVSEDEK
     TVDDHNAACA MDLHITSSSA SSHVSENGCN QQSHGESLPV TSVDKVHTSD ASCEDNKLKN
     HFITSEVCSD ATNLSASGLL TEEENIHNVE DQYEGPLPSE ESSGCLDYPH DDHNSEKEDI
     HQPDGYAASP GNNNHFDSSH EGGYLHAEQP PVMGWTVRPQ MLHPNYGISM EENQFEPKVE
     DHLLIKKPVS IRNIPRNPLV DAVAAHDRST MRKVSELVAP TDKSKPNERN LLLEQIRNKT
     FNLKPVSSAK QPTIRTPPRA STRNLKVAAI IEKANAIRQA VGSDDEDGDN WSESSDT