SCRL2_ORYSJ
ID SCRL2_ORYSJ Reviewed; 1334 AA.
AC Q5QNA6; C7IWQ9;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=SCAR-like protein 2;
GN OrderedLocusNames=Os01g0208600, LOC_Os01g11040; ORFNames=OSJNBa0016I09.25;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12447438; DOI=10.1038/nature01184;
RA Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y.,
RA Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H.,
RA Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.,
RA Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M.,
RA Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T.,
RA Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S.,
RA Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H.,
RA Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y.,
RA Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S.,
RA Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y.,
RA Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S.,
RA Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H.,
RA Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.;
RT "The genome sequence and structure of rice chromosome 1.";
RL Nature 420:312-316(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
CC -!- FUNCTION: Involved in regulation of actin and microtubule organization.
CC Part of a WAVE complex that activates the Arp2/3 complex (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SCAR/WAVE family. {ECO:0000305}.
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DR EMBL; AP003052; BAD73100.1; -; Genomic_DNA.
DR EMBL; AP008207; BAH90957.1; -; Genomic_DNA.
DR EMBL; AP014957; BAS70961.1; -; Genomic_DNA.
DR EMBL; AK067713; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK104676; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK120865; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; XP_015649279.1; XM_015793793.1.
DR AlphaFoldDB; Q5QNA6; -.
DR STRING; 4530.OS01T0208600-01; -.
DR PaxDb; Q5QNA6; -.
DR PRIDE; Q5QNA6; -.
DR EnsemblPlants; Os01t0208600-01; Os01t0208600-01; Os01g0208600.
DR GeneID; 9268854; -.
DR Gramene; Os01t0208600-01; Os01t0208600-01; Os01g0208600.
DR KEGG; osa:9268854; -.
DR eggNOG; ENOG502QSPV; Eukaryota.
DR HOGENOM; CLU_005038_1_0_1; -.
DR InParanoid; Q5QNA6; -.
DR OMA; IPCANER; -.
DR OrthoDB; 594491at2759; -.
DR Proteomes; UP000000763; Chromosome 1.
DR Proteomes; UP000059680; Chromosome 1.
DR ExpressionAtlas; Q5QNA6; baseline and differential.
DR Genevisible; Q5QNA6; OS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0071933; F:Arp2/3 complex binding; IBA:GO_Central.
DR GO; GO:0034237; F:protein kinase A regulatory subunit binding; IBA:GO_Central.
DR GO; GO:0030036; P:actin cytoskeleton organization; IBA:GO_Central.
DR GO; GO:2000601; P:positive regulation of Arp2/3 complex-mediated actin nucleation; IBA:GO_Central.
DR InterPro; IPR028288; SCAR/WAVE_fam.
DR InterPro; IPR003124; WH2_dom.
DR PANTHER; PTHR12902; PTHR12902; 1.
DR PROSITE; PS51082; WH2; 1.
PE 2: Evidence at transcript level;
KW Actin-binding; Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..1334
FT /note="SCAR-like protein 2"
FT /id="PRO_0000189010"
FT DOMAIN 1271..1289
FT /note="WH2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00406"
FT REGION 197..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 294..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 481..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 568..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 643..668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 791..832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 931..956
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1000..1026
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1248..1268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1280..1304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 481..500
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 577..591
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..659
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 940..956
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1003..1026
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1250..1268
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 32
FT /note="G -> R (in Ref. 5; AK120865)"
FT /evidence="ECO:0000305"
FT CONFLICT 38
FT /note="A -> V (in Ref. 5; AK120865)"
FT /evidence="ECO:0000305"
FT CONFLICT 209
FT /note="K -> E (in Ref. 5; AK120865)"
FT /evidence="ECO:0000305"
FT CONFLICT 598
FT /note="P -> S (in Ref. 5; AK120865)"
FT /evidence="ECO:0000305"
FT CONFLICT 768
FT /note="Y -> C (in Ref. 5; AK067713)"
FT /evidence="ECO:0000305"
FT CONFLICT 870
FT /note="S -> T (in Ref. 5; AK067713)"
FT /evidence="ECO:0000305"
FT CONFLICT 915
FT /note="Q -> K (in Ref. 5; AK067713)"
FT /evidence="ECO:0000305"
FT CONFLICT 1315
FT /note="A -> V (in Ref. 5; AK104676)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1334 AA; 144358 MW; B53B20DD81750E6F CRC64;
MPLVRFEVRN EVGLGDPDLY GGGGGGGGGG GGGGVGAAAK KGGEAEPKAL LEGVAVAGLV
GILRQLGDLA EFAADVFHDL HEQVITTSAR GRKVLTRVQN IEAALPSLEK AVKNQKSHIH
FTYVPGSDWH AQLKDEQNHL LSSDLPRFMM DSYEECRDPP RLYLLDKFDN AGAGACSRRH
SDPSYFKKAW DMMRADKTGN FQREKKSQKI KRKGSRLREP YHGQTTPRQR NGELQRALTA
VQLTSRHFAT PSTDGRSLSE NRSTSDVRSN PDNISRSSSF SSKARLSFTE QVLDTKPTVV
PHENGHDKLS NNNLHKLSNT PLHTRLNGTS ADDLGDDLKQ SSLLDDMTAR SPSVKWDEKA
EITMSTTSVY CDDVVMDKAE HVQSKCISPE QQEIDHREME TLEQQEALHQ KAKQLLVSSG
LNHHDEVPSE TDNYVDALNT LESETETEPE LQTKSRVKPV PSLNVDVPQV ELIDNIVTES
PDSSVAEFPD AYQNSSMPPA PESAADFPSL SSADAPDISE PVLSGYTANP HPEVSAIATN
TPVSNTEDAP GPLEISESAS RAYIITLPNQ SLPDSKEIPD SKAEDAPIDS PEKLEPGPSS
YTPTIPIKES SIVSQNTNAE NVSGDCSEGT ACAISYSQHI ISDKPTNEVS ATNSSPDDTS
SDEDTVESGG IVEVSNSQPM PLNDSLENGC ATQGLPANAP TNSTGVSSVK LWTNAGLFGL
EPSKPPVFGA HDGPKEDTTP GHTQPQLCHS TGCPEVHFSK PTESAQVYVP NGNSPITSSF
VGKLVGICPG STSHSSETNQ STVRTPDTVI GQTEGSTGCS TSFEHSDHKN IIGKQTSISE
LLESEDSAEN GAEMFSKTDM TGRNNMNQVS ASSFSSIAQR FLANTLQRRT PKYTDLPMSS
VIVNTDANGT DESTQISSLA PNETTFEASQ FEKKTENDTN GLPKSSLFSS SHYSEKSSPP
LEYMKISFHP MSAFEMSKLD LDFSDENLHE NADDMMLPTF QLLPGSSVPQ LGSGSESEDD
TFGRSYSYSS YDDLSPRLYS NSELWDQEDA NGLEDHDMHN NPNQIGSFGA PISSFVEFEQ
MDLSGAKSTV SLTDLGDDNG LGTLDSHPAG ELPNFDTLMA HQNEAFIPHN PVSLSPDEGQ
LPPPPPLPPM QWRTMRQVAS VEEGRGSAAK EDMLESTSDL PPVHTPVQEE HLLPIAPPDQ
QNLLPIAPPD QQGHAKENDR KVDGVKEISN PLDIEIRASL LQQIRDKSGQ QKLNGHEKSK
AVGNDTKNLD EREELLQQIR SKTFNLRRTN ASKTNTSSPT TANSSVVAIL EKANAIRQAV
ASDEGGDDDS WSDI
