ID   SCRN1_BOVIN             Reviewed;         414 AA.
AC   P83939;
DT   07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 2.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Secernin-1;
DE   AltName: Full=p50;
GN   Name=SCRN1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford;
RX   PubMed=19390049; DOI=10.1126/science.1169588;
RG   The bovine genome sequencing and analysis consortium;
RT   "The genome sequence of taurine cattle: a window to ruminant biology and
RT   evolution.";
RL   Science 324:522-528(2009).
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 17-32; 65-72; 99-115; 198-206; 304-315; 337-365 AND
RP   370-377.
RC   TISSUE=Brain {ECO:0000269|PubMed:12221138};
RX   PubMed=12221138; DOI=10.1091/mbc.e01-10-0094;
RA   Way G., Morrice N., Smythe C., O'Sullivan A.J.O.;
RT   "Purification and identification of secernin, a novel cytosolic protein
RT   that regulates exocytosis in mast cells.";
RL   Mol. Biol. Cell 13:3344-3354(2002).
CC   -!- FUNCTION: Regulates exocytosis in mast cells. Increases both the extent
CC       of secretion and the sensitivity of mast cells to stimulation with
CC       calcium. {ECO:0000269|PubMed:12221138}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- MISCELLANEOUS: 'Secern' is an archaic English term meaning 'secrete'.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase C69 family. Secernin subfamily.
CC       {ECO:0000305}.
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DR   RefSeq; XP_010802602.1; XM_010804300.2.
DR   RefSeq; XP_010802603.1; XM_010804301.2.
DR   AlphaFoldDB; P83939; -.
DR   SMR; P83939; -.
DR   STRING; 9913.ENSBTAP00000021588; -.
DR   PaxDb; P83939; -.
DR   PRIDE; P83939; -.
DR   Ensembl; ENSBTAT00000021588; ENSBTAP00000021588; ENSBTAG00000016223.
DR   GeneID; 534933; -.
DR   CTD; 9805; -.
DR   VEuPathDB; HostDB:ENSBTAG00000016223; -.
DR   VGNC; VGNC:34366; SCRN1.
DR   eggNOG; ENOG502QTSN; Eukaryota.
DR   GeneTree; ENSGT00390000013474; -.
DR   HOGENOM; CLU_046840_0_0_1; -.
DR   InParanoid; P83939; -.
DR   OMA; SSCHTFQ; -.
DR   OrthoDB; 322959at2759; -.
DR   TreeFam; TF323890; -.
DR   Proteomes; UP000009136; Chromosome 4.
DR   Bgee; ENSBTAG00000016223; Expressed in prefrontal cortex and 101 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR   GO; GO:0070004; F:cysteine-type exopeptidase activity; IEA:InterPro.
DR   GO; GO:0016805; F:dipeptidase activity; IEA:InterPro.
DR   GO; GO:0006887; P:exocytosis; IDA:UniProtKB.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   InterPro; IPR005322; Peptidase_C69.
DR   PANTHER; PTHR12994; PTHR12994; 1.
DR   Pfam; PF03577; Peptidase_C69; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Cytoplasm; Direct protein sequencing; Exocytosis;
KW   Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q12765"
FT   CHAIN           2..414
FT                   /note="Secernin-1"
FT                   /id="PRO_0000221435"
FT   ACT_SITE        9
FT                   /evidence="ECO:0000255"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q12765"
FT   CONFLICT        70..71
FT                   /note="IS -> AE (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   414 AA;  46202 MW;  C7419065A5D3DA77 CRC64;
     MAVAPPSYCF VAFPPRAKDG LVVFGKNSAR PRDEVQEVVY FSAADHEPES KVECTYISIN
     QVPRTHAIVI SRPAWLWGAE MGANEHGVCI ANEAINAREP AAETEALLGM DLVRLGLERG
     ATAKEALDVI VALLEEHGQG GNYYEDANSC HSFQSAFLIV DREEAWVLET VGKYWAAEKI
     TEGVKCICNQ LSLTTKIDAE HPELRSYAQS QGWWMGEDEF NFSEVFSPAD DHLTCCSGRD
     TLEKQEESIT VQTMIDVLRD KASGVCVDSE SFLTTASVVS VLPQNGSSPC IHYFTGTPDP
     SRSIFKPFIF VDDVKLVPKA QSPCFGDDDP AKKEPRFQEK PDRRHELYKA HEWARAVLES
     DEEQGQKLRK TMLELEKQGL EAMEEILTSS DPLDPTEVGD LFYDCVDTEI KFFK