SCRN1_MOUSE
ID SCRN1_MOUSE Reviewed; 414 AA.
AC Q9CZC8; Q3UKR2; Q8CCL3;
DT 16-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Secernin-1;
GN Name=Scrn1; Synonyms=Kiaa0193;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, Pancreas, Placenta, and Spinal cord;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: III.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:167-180(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PROTEIN SEQUENCE OF 33-51 AND 262-302, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC TISSUE=Hippocampus;
RA Lubec G., Klug S.;
RL Submitted (MAR-2007) to UniProtKB.
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Lung, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Regulates exocytosis in mast cells. Increases both the extent
CC of secretion and the sensitivity of mast cells to stimulation with
CC calcium (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- MISCELLANEOUS: 'Secern' is an archaic English term meaning 'secrete'.
CC -!- SIMILARITY: Belongs to the peptidase C69 family. Secernin subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC97894.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK012765; BAB28453.1; -; mRNA.
DR EMBL; AK032573; BAC27931.1; -; mRNA.
DR EMBL; AK050481; BAC34280.1; -; mRNA.
DR EMBL; AK082953; BAC38706.1; -; mRNA.
DR EMBL; AK145904; BAE26739.1; -; mRNA.
DR EMBL; AK129084; BAC97894.1; ALT_INIT; mRNA.
DR EMBL; BC023889; AAH23889.1; -; mRNA.
DR CCDS; CCDS20156.1; -.
DR RefSeq; NP_081544.1; NM_027268.2.
DR RefSeq; XP_006506635.1; XM_006506572.2.
DR RefSeq; XP_011239761.1; XM_011241459.2.
DR AlphaFoldDB; Q9CZC8; -.
DR SMR; Q9CZC8; -.
DR BioGRID; 213767; 7.
DR IntAct; Q9CZC8; 1.
DR STRING; 10090.ENSMUSP00000019268; -.
DR MEROPS; C69.003; -.
DR iPTMnet; Q9CZC8; -.
DR PhosphoSitePlus; Q9CZC8; -.
DR MaxQB; Q9CZC8; -.
DR PaxDb; Q9CZC8; -.
DR PeptideAtlas; Q9CZC8; -.
DR PRIDE; Q9CZC8; -.
DR ProteomicsDB; 256715; -.
DR Antibodypedia; 12563; 189 antibodies from 28 providers.
DR DNASU; 69938; -.
DR Ensembl; ENSMUST00000019268; ENSMUSP00000019268; ENSMUSG00000019124.
DR GeneID; 69938; -.
DR KEGG; mmu:69938; -.
DR UCSC; uc009bzw.1; mouse.
DR CTD; 9805; -.
DR MGI; MGI:1917188; Scrn1.
DR VEuPathDB; HostDB:ENSMUSG00000019124; -.
DR eggNOG; ENOG502QTSN; Eukaryota.
DR GeneTree; ENSGT00390000013474; -.
DR HOGENOM; CLU_046840_0_0_1; -.
DR InParanoid; Q9CZC8; -.
DR OMA; SSCHTFQ; -.
DR OrthoDB; 322959at2759; -.
DR PhylomeDB; Q9CZC8; -.
DR TreeFam; TF323890; -.
DR BioGRID-ORCS; 69938; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Scrn1; mouse.
DR PRO; PR:Q9CZC8; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q9CZC8; protein.
DR Bgee; ENSMUSG00000019124; Expressed in otolith organ and 215 other tissues.
DR ExpressionAtlas; Q9CZC8; baseline and differential.
DR Genevisible; Q9CZC8; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0031965; C:nuclear membrane; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0070004; F:cysteine-type exopeptidase activity; IEA:InterPro.
DR GO; GO:0016805; F:dipeptidase activity; IEA:InterPro.
DR GO; GO:0006887; P:exocytosis; ISS:UniProtKB.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR InterPro; IPR005322; Peptidase_C69.
DR PANTHER; PTHR12994; PTHR12994; 1.
DR Pfam; PF03577; Peptidase_C69; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Direct protein sequencing; Exocytosis; Reference proteome.
FT CHAIN 1..414
FT /note="Secernin-1"
FT /id="PRO_0000221437"
FT CONFLICT 127
FT /note="L -> I (in Ref. 1; BAE26739)"
FT /evidence="ECO:0000305"
FT CONFLICT 391
FT /note="E -> K (in Ref. 1; BAC27931)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 414 AA; 46326 MW; F5C530AC5562D3BA CRC64;
MSGAPPSYSF VALPPRAKDG LVVFGKNSAR PRDEVQEVVY FPAVDHDAES KVECTYISID
QVPRTHAIVI SRPAWLWGAE MGANEHGVCI ANEAINAREP AAETEALLGM DLVRLGLERG
TTAKEALDII VSLLDEHGQG GNYYEDAHSC HSFQSAYLLV DRDEAWVLET VGKYWAAERI
TEGVRCICNH LSLATKLDEE HPELRTYAQS QGWWTGDDEF NFAQVFSPAD DRLDCCAGQD
SLEKQEESIT VQTMINILRD KASGVCIDSE SFLTTASIVS VLPQNRSSPC IHYFTGTPDP
SRSIFKPFIF VDDVKLVPKA QSPCFGDDDP AKKEPRFQEK PDRRHELYKA HEWARAVIES
DEEQGRTLRK TMLELEKQGL EAMDEILSSP EPPDPAEVGD LFYDCVDTEM KFFK
