ID   SCRN2_DANRE             Reviewed;         415 AA.
AC   Q5TYS5;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Secernin-2;
GN   Name=scrn2; ORFNames=si:ch211-184m19.2;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase C69 family. Secernin subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BX901920; CAH68895.1; -; Genomic_DNA.
DR   EMBL; BC124746; AAI24747.1; -; mRNA.
DR   RefSeq; NP_001025287.1; NM_001030116.1.
DR   RefSeq; XP_005160490.1; XM_005160433.1.
DR   RefSeq; XP_005160491.1; XM_005160434.1.
DR   AlphaFoldDB; Q5TYS5; -.
DR   SMR; Q5TYS5; -.
DR   STRING; 7955.ENSDARP00000063856; -.
DR   PaxDb; Q5TYS5; -.
DR   Ensembl; ENSDART00000063857; ENSDARP00000063856; ENSDARG00000043497.
DR   Ensembl; ENSDART00000161314; ENSDARP00000131124; ENSDARG00000043497.
DR   GeneID; 558306; -.
DR   KEGG; dre:558306; -.
DR   CTD; 90507; -.
DR   ZFIN; ZDB-GENE-040724-75; scrn2.
DR   eggNOG; ENOG502QPIA; Eukaryota.
DR   GeneTree; ENSGT00390000013474; -.
DR   InParanoid; Q5TYS5; -.
DR   OMA; AKAQGWW; -.
DR   OrthoDB; 322959at2759; -.
DR   PhylomeDB; Q5TYS5; -.
DR   TreeFam; TF323890; -.
DR   PRO; PR:Q5TYS5; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 20.
DR   Bgee; ENSDARG00000043497; Expressed in bone element and 24 other tissues.
DR   ExpressionAtlas; Q5TYS5; baseline and differential.
DR   GO; GO:0070004; F:cysteine-type exopeptidase activity; IEA:InterPro.
DR   GO; GO:0016805; F:dipeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   InterPro; IPR005322; Peptidase_C69.
DR   PANTHER; PTHR12994; PTHR12994; 1.
DR   Pfam; PF03577; Peptidase_C69; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..415
FT                   /note="Secernin-2"
FT                   /id="PRO_0000262555"
FT   ACT_SITE        8
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   415 AA;  46041 MW;  60DBFC7BD037BDF0 CRC64;
     MAEPPRSCDC FVSLPPGSKE DYVIFGKNSD RPRDEVQEVV YFPASSHPPA STVECTYISI
     PQVEHTNAVV LSRPAWLWGA EMGANEHGVC VGNEAVWTKE PVNPEEALLG MDLVRLGLER
     GDSARAALNV ITALLEQFGQ GGACRETSEP FSYHNTFLLV DRQEAWVLET AGKLWAAQKV
     TEGVKNISNQ LTIDFEISAE HPDLRSVAQA QGWWSGEGDF SFTAVFSPDH PPARMEMAKQ
     RYRGGTALLQ QHNGSVTAEV MMSILRDKAS GICMDSEGFR TTGSMVSILP RNPNMPCVHF
     LTATPDPSRS VFKPFIFSES VRPVSMVMSP QYGPGDPVRT LPRFQHQVDR KHELYKAHQM
     ANTSSDAGVS LQDTMRYLES QCLEEIEAML RGEVQGQELG DLFFDCVDAE IKFYQ