SCRN2_HUMAN
ID SCRN2_HUMAN Reviewed; 425 AA.
AC Q96FV2; A8K3N1; B7Z8S7; E9PBV5; Q96AC3; Q9BU04;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 3.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Secernin-2;
GN Name=SCRN2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP VAL-323.
RC TISSUE=Embryo, and Ovary;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT VAL-323.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANTS
RP ARG-103; VAL-323 AND GLY-411.
RC TISSUE=Lung, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-52, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-52, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- INTERACTION:
CC Q96FV2; Q92993: KAT5; NbExp=3; IntAct=EBI-11306862, EBI-399080;
CC Q96FV2; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-11306862, EBI-16439278;
CC Q96FV2; P50542-3: PEX5; NbExp=3; IntAct=EBI-11306862, EBI-12181987;
CC Q96FV2; Q9BSI4: TINF2; NbExp=2; IntAct=EBI-11306862, EBI-717399;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96FV2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96FV2-2; Sequence=VSP_044566;
CC -!- SIMILARITY: Belongs to the peptidase C69 family. Secernin subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH10408.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK290646; BAF83335.1; -; mRNA.
DR EMBL; AK303835; BAH14063.1; -; mRNA.
DR EMBL; AC003665; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471109; EAW94791.1; -; Genomic_DNA.
DR EMBL; CH471109; EAW94792.1; -; Genomic_DNA.
DR EMBL; BC002980; AAH02980.1; -; mRNA.
DR EMBL; BC010408; AAH10408.2; ALT_INIT; mRNA.
DR EMBL; BC017317; AAH17317.1; -; mRNA.
DR CCDS; CCDS11519.1; -. [Q96FV2-1]
DR CCDS; CCDS45723.1; -. [Q96FV2-2]
DR RefSeq; NP_001138495.1; NM_001145023.1. [Q96FV2-2]
DR RefSeq; NP_612364.2; NM_138355.3. [Q96FV2-1]
DR RefSeq; XP_005257833.1; XM_005257776.4. [Q96FV2-1]
DR AlphaFoldDB; Q96FV2; -.
DR SMR; Q96FV2; -.
DR BioGRID; 124726; 25.
DR IntAct; Q96FV2; 14.
DR STRING; 9606.ENSP00000290216; -.
DR MEROPS; C69.004; -.
DR iPTMnet; Q96FV2; -.
DR MetOSite; Q96FV2; -.
DR PhosphoSitePlus; Q96FV2; -.
DR BioMuta; SCRN2; -.
DR DMDM; 317373511; -.
DR REPRODUCTION-2DPAGE; IPI00062266; -.
DR EPD; Q96FV2; -.
DR jPOST; Q96FV2; -.
DR MassIVE; Q96FV2; -.
DR MaxQB; Q96FV2; -.
DR PaxDb; Q96FV2; -.
DR PeptideAtlas; Q96FV2; -.
DR PRIDE; Q96FV2; -.
DR ProteomicsDB; 19303; -.
DR ProteomicsDB; 76559; -. [Q96FV2-1]
DR Antibodypedia; 17779; 169 antibodies from 29 providers.
DR DNASU; 90507; -.
DR Ensembl; ENST00000290216.14; ENSP00000290216.9; ENSG00000141295.14. [Q96FV2-1]
DR Ensembl; ENST00000407215.7; ENSP00000383935.3; ENSG00000141295.14. [Q96FV2-2]
DR GeneID; 90507; -.
DR KEGG; hsa:90507; -.
DR MANE-Select; ENST00000290216.14; ENSP00000290216.9; NM_138355.4; NP_612364.2.
DR UCSC; uc002imd.4; human. [Q96FV2-1]
DR CTD; 90507; -.
DR DisGeNET; 90507; -.
DR GeneCards; SCRN2; -.
DR HGNC; HGNC:30381; SCRN2.
DR HPA; ENSG00000141295; Low tissue specificity.
DR MIM; 614966; gene.
DR neXtProt; NX_Q96FV2; -.
DR OpenTargets; ENSG00000141295; -.
DR PharmGKB; PA134964266; -.
DR VEuPathDB; HostDB:ENSG00000141295; -.
DR eggNOG; ENOG502QPIA; Eukaryota.
DR GeneTree; ENSGT00390000013474; -.
DR HOGENOM; CLU_046840_0_0_1; -.
DR InParanoid; Q96FV2; -.
DR OrthoDB; 322959at2759; -.
DR PhylomeDB; Q96FV2; -.
DR TreeFam; TF323890; -.
DR PathwayCommons; Q96FV2; -.
DR SignaLink; Q96FV2; -.
DR BioGRID-ORCS; 90507; 34 hits in 1076 CRISPR screens.
DR ChiTaRS; SCRN2; human.
DR GenomeRNAi; 90507; -.
DR Pharos; Q96FV2; Tdark.
DR PRO; PR:Q96FV2; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q96FV2; protein.
DR Bgee; ENSG00000141295; Expressed in apex of heart and 163 other tissues.
DR ExpressionAtlas; Q96FV2; baseline and differential.
DR Genevisible; Q96FV2; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0070004; F:cysteine-type exopeptidase activity; IEA:InterPro.
DR GO; GO:0016805; F:dipeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR InterPro; IPR005322; Peptidase_C69.
DR PANTHER; PTHR12994; PTHR12994; 1.
DR Pfam; PF03577; Peptidase_C69; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..425
FT /note="Secernin-2"
FT /id="PRO_0000262552"
FT ACT_SITE 12
FT /evidence="ECO:0000255"
FT MOD_RES 52
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163,
FT ECO:0007744|PubMed:24275569"
FT VAR_SEQ 374..425
FT /note="DRGQQLQQKQQDLEQEGLEATQGLLAGEWAPPLWELGSLFQAFVKRESQAYA
FT -> VSPRE (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_044566"
FT VARIANT 103
FT /note="K -> R (in dbSNP:rs17856536)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_029509"
FT VARIANT 273
FT /note="E -> Q (in dbSNP:rs35901087)"
FT /id="VAR_035263"
FT VARIANT 323
FT /note="M -> V (in dbSNP:rs7350974)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.3"
FT /id="VAR_029510"
FT VARIANT 330
FT /note="Q -> R (in dbSNP:rs34480825)"
FT /id="VAR_035264"
FT VARIANT 411
FT /note="S -> G (in dbSNP:rs17856535)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_029511"
SQ SEQUENCE 425 AA; 46597 MW; AA7A0290D920B359 CRC64;
MASSSPDSPC SCDCFVSVPP ASAIPAVIFA KNSDRPRDEV QEVVFVPAGT HTPGSRLQCT
YIEVEQVSKT HAVILSRPSW LWGAEMGANE HGVCIGNEAV WTKEPVGEGE ALLGMDLLRL
ALERSSSAQE ALHVITGLLE HYGQGGNCLE DAAPFSYHST FLLADRTEAW VLETAGRLWA
AQRIQEGARN ISNQLSIGTD ISAQHPELRT HAQAKGWWDG QGAFDFAQIF SLTQQPVRME
AAKARFQAGR ELLRQRQGGI TAEVMMGILR DKESGICMDS GGFRTTASMV SVLPQDPTQP
CVHFLTATPD PSRSVFKPFI FGMGVAQAPQ VLSPTFGAQD PVRTLPRFQT QVDRRHTLYR
GHQAALGLME RDQDRGQQLQ QKQQDLEQEG LEATQGLLAG EWAPPLWELG SLFQAFVKRE
SQAYA
