SCRN3_HUMAN
ID SCRN3_HUMAN Reviewed; 424 AA.
AC Q0VDG4; B4DI11; C9JPC1; D3DPE0; Q7L1C5; Q9H5R5;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Secernin-3;
GN Name=SCRN3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 186-424 (ISOFORM 1).
RC TISSUE=Corpus callosum, and Lung;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [6]
RP VARIANT SER-108.
RX PubMed=22464252; DOI=10.1016/j.ajhg.2012.03.004;
RA Lee H., Graham J.M. Jr., Rimoin D.L., Lachman R.S., Krejci P.,
RA Tompson S.W., Nelson S.F., Krakow D., Cohn D.H.;
RT "Exome sequencing identifies PDE4D mutations in acrodysostosis.";
RL Am. J. Hum. Genet. 90:746-751(2012).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q0VDG4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q0VDG4-2; Sequence=VSP_042720;
CC -!- SIMILARITY: Belongs to the peptidase C69 family. Secernin subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAY24217.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AK295357; BAG58323.1; -; mRNA.
DR EMBL; AC018470; AAY24217.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CH471058; EAX11140.1; -; Genomic_DNA.
DR EMBL; CH471058; EAX11141.1; -; Genomic_DNA.
DR EMBL; CH471058; EAX11142.1; -; Genomic_DNA.
DR EMBL; BC031821; AAH31821.2; -; mRNA.
DR EMBL; BC119685; AAI19686.1; -; mRNA.
DR EMBL; AK026795; BAB15555.1; -; mRNA.
DR CCDS; CCDS2258.1; -. [Q0VDG4-1]
DR CCDS; CCDS54420.1; -. [Q0VDG4-2]
DR RefSeq; NP_001180457.1; NM_001193528.1. [Q0VDG4-2]
DR RefSeq; NP_078859.2; NM_024583.4. [Q0VDG4-1]
DR RefSeq; XP_005246911.1; XM_005246854.4. [Q0VDG4-1]
DR RefSeq; XP_005246912.1; XM_005246855.2. [Q0VDG4-1]
DR RefSeq; XP_005246913.1; XM_005246856.2. [Q0VDG4-1]
DR RefSeq; XP_005246914.1; XM_005246857.2. [Q0VDG4-1]
DR RefSeq; XP_016860398.1; XM_017004909.1.
DR RefSeq; XP_016860399.1; XM_017004910.1. [Q0VDG4-1]
DR AlphaFoldDB; Q0VDG4; -.
DR SMR; Q0VDG4; -.
DR BioGRID; 122764; 15.
DR IntAct; Q0VDG4; 6.
DR STRING; 9606.ENSP00000272732; -.
DR MEROPS; C69.005; -.
DR iPTMnet; Q0VDG4; -.
DR MetOSite; Q0VDG4; -.
DR PhosphoSitePlus; Q0VDG4; -.
DR BioMuta; SCRN3; -.
DR DMDM; 118573861; -.
DR EPD; Q0VDG4; -.
DR jPOST; Q0VDG4; -.
DR MassIVE; Q0VDG4; -.
DR MaxQB; Q0VDG4; -.
DR PaxDb; Q0VDG4; -.
DR PeptideAtlas; Q0VDG4; -.
DR PRIDE; Q0VDG4; -.
DR ProteomicsDB; 58826; -. [Q0VDG4-1]
DR ProteomicsDB; 58827; -. [Q0VDG4-2]
DR Antibodypedia; 47621; 105 antibodies from 25 providers.
DR DNASU; 79634; -.
DR Ensembl; ENST00000272732.11; ENSP00000272732.6; ENSG00000144306.15. [Q0VDG4-1]
DR Ensembl; ENST00000409673.7; ENSP00000387142.3; ENSG00000144306.15. [Q0VDG4-2]
DR GeneID; 79634; -.
DR KEGG; hsa:79634; -.
DR MANE-Select; ENST00000272732.11; ENSP00000272732.6; NM_024583.5; NP_078859.2.
DR UCSC; uc002uiq.4; human. [Q0VDG4-1]
DR CTD; 79634; -.
DR DisGeNET; 79634; -.
DR GeneCards; SCRN3; -.
DR HGNC; HGNC:30382; SCRN3.
DR HPA; ENSG00000144306; Low tissue specificity.
DR MIM; 614967; gene.
DR neXtProt; NX_Q0VDG4; -.
DR OpenTargets; ENSG00000144306; -.
DR PharmGKB; PA134974313; -.
DR VEuPathDB; HostDB:ENSG00000144306; -.
DR eggNOG; ENOG502QPIA; Eukaryota.
DR GeneTree; ENSGT00390000013474; -.
DR HOGENOM; CLU_046840_0_0_1; -.
DR InParanoid; Q0VDG4; -.
DR OMA; EMENGWI; -.
DR OrthoDB; 322959at2759; -.
DR PhylomeDB; Q0VDG4; -.
DR TreeFam; TF323890; -.
DR PathwayCommons; Q0VDG4; -.
DR SignaLink; Q0VDG4; -.
DR BioGRID-ORCS; 79634; 13 hits in 1079 CRISPR screens.
DR ChiTaRS; SCRN3; human.
DR GenomeRNAi; 79634; -.
DR Pharos; Q0VDG4; Tbio.
DR PRO; PR:Q0VDG4; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q0VDG4; protein.
DR Bgee; ENSG00000144306; Expressed in cortical plate and 183 other tissues.
DR ExpressionAtlas; Q0VDG4; baseline and differential.
DR Genevisible; Q0VDG4; HS.
DR GO; GO:0070004; F:cysteine-type exopeptidase activity; IEA:InterPro.
DR GO; GO:0016805; F:dipeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR InterPro; IPR005322; Peptidase_C69.
DR PANTHER; PTHR12994; PTHR12994; 1.
DR Pfam; PF03577; Peptidase_C69; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..424
FT /note="Secernin-3"
FT /id="PRO_0000262559"
FT ACT_SITE 6
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..27
FT /note="MEPFSCDTFVALPPATVDNRIIFGKNS -> MPPLATPPSVHLSLRVAGRP
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_042720"
FT VARIANT 18
FT /note="D -> N (in dbSNP:rs10497410)"
FT /id="VAR_053611"
FT VARIANT 108
FT /note="L -> S"
FT /evidence="ECO:0000269|PubMed:22464252"
FT /id="VAR_069467"
FT VARIANT 179
FT /note="V -> A (in dbSNP:rs6716400)"
FT /id="VAR_034487"
SQ SEQUENCE 424 AA; 48544 MW; C50D5DFFD413AC9D CRC64;
MEPFSCDTFV ALPPATVDNR IIFGKNSDRL YDEVQEVVYF PAVVHDNLGE RLKCTYIEID
QVPETYAVVL SRPAWLWGAE MGANEHGVCI GNEAVWGREE VCDEEALLGM DLVRLGLERA
DTAEKALNVI VDLLEKYGQG GNCTEGRMVF SYHNSFLIAD RNEAWILETA GKYWAAEKVQ
EGVRNISNQL SITTKIAREH PDMRNYAKRK GWWDGKKEFD FAAAYSYLDT AKMMTSSGRY
CEGYKLLNKH KGNITFETMM EILRDKPSGI NMEGEFLTTA SMVSILPQDS SLPCIHFFTG
TPDPERSVFK PFIFVPHISQ LLDTSSPTFE LEDLVKKKSH FKPDRRHPLY QKHQQALEVV
NNNEEKAKIM LDNMRKLEKE LFREMESILQ NKHLDVEKIV NLFPQCTKDE IQIYQSNLSV
KVSS
