SCRN3_MOUSE
ID SCRN3_MOUSE Reviewed; 418 AA.
AC Q3TMH2; A2AWR0; Q91WF6; Q9CUT0;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Secernin-3;
GN Name=Scrn3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head, and Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PROTEIN SEQUENCE OF 30-50; 99-114; 126-136; 148-171; 250-262 AND 397-406,
RP AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=OF1; TISSUE=Hippocampus;
RA Lubec G., Sunyer B., Chen W.-Q.;
RL Submitted (JAN-2009) to UniProtKB.
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Pancreas, Spleen,
RC and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the peptidase C69 family. Secernin subfamily.
CC {ECO:0000305}.
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DR EMBL; AK014701; BAB29511.3; -; mRNA.
DR EMBL; AK165936; BAE38470.1; -; mRNA.
DR EMBL; AL954713; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466519; EDL27127.1; -; Genomic_DNA.
DR EMBL; BC015296; AAH15296.1; -; mRNA.
DR EMBL; BC139390; AAI39391.1; -; mRNA.
DR EMBL; BC139391; AAI39392.1; -; mRNA.
DR CCDS; CCDS16128.1; -.
DR RefSeq; NP_083298.1; NM_029022.1.
DR RefSeq; XP_006500377.1; XM_006500314.2.
DR AlphaFoldDB; Q3TMH2; -.
DR SMR; Q3TMH2; -.
DR STRING; 10090.ENSMUSP00000088320; -.
DR MEROPS; C69.005; -.
DR iPTMnet; Q3TMH2; -.
DR PhosphoSitePlus; Q3TMH2; -.
DR SwissPalm; Q3TMH2; -.
DR EPD; Q3TMH2; -.
DR jPOST; Q3TMH2; -.
DR MaxQB; Q3TMH2; -.
DR PaxDb; Q3TMH2; -.
DR PeptideAtlas; Q3TMH2; -.
DR PRIDE; Q3TMH2; -.
DR ProteomicsDB; 255497; -.
DR Antibodypedia; 47621; 105 antibodies from 25 providers.
DR DNASU; 74616; -.
DR Ensembl; ENSMUST00000090811; ENSMUSP00000088320; ENSMUSG00000008226.
DR GeneID; 74616; -.
DR KEGG; mmu:74616; -.
DR UCSC; uc008kcm.1; mouse.
DR CTD; 79634; -.
DR MGI; MGI:1921866; Scrn3.
DR VEuPathDB; HostDB:ENSMUSG00000008226; -.
DR eggNOG; ENOG502QPIA; Eukaryota.
DR GeneTree; ENSGT00390000013474; -.
DR HOGENOM; CLU_046840_0_0_1; -.
DR InParanoid; Q3TMH2; -.
DR OMA; QDSNLPC; -.
DR OrthoDB; 322959at2759; -.
DR PhylomeDB; Q3TMH2; -.
DR TreeFam; TF323890; -.
DR BioGRID-ORCS; 74616; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Scrn3; mouse.
DR PRO; PR:Q3TMH2; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q3TMH2; protein.
DR Bgee; ENSMUSG00000008226; Expressed in muscle of arm and 233 other tissues.
DR ExpressionAtlas; Q3TMH2; baseline and differential.
DR Genevisible; Q3TMH2; MM.
DR GO; GO:0070004; F:cysteine-type exopeptidase activity; IEA:InterPro.
DR GO; GO:0016805; F:dipeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR InterPro; IPR005322; Peptidase_C69.
DR PANTHER; PTHR12994; PTHR12994; 1.
DR Pfam; PF03577; Peptidase_C69; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Reference proteome.
FT CHAIN 1..418
FT /note="Secernin-3"
FT /id="PRO_0000262560"
FT ACT_SITE 6
FT /evidence="ECO:0000255"
FT CONFLICT 414
FT /note="S -> P (in Ref. 1; BAB29511)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 418 AA; 47661 MW; C1A618577829929B CRC64;
MEPYSCDTFV ALPPATVGNR VIFGKNSDRL FDEVQEVIYC PAAVHNDLEK RLKCTYIEVD
QVPETYAVVL SRPAWLWGAE MGANEHGVCI GNEAVWGRED ISKEEALLGM DLVRLGLERA
DTAEKALDVI VDLLEKYGQG GNCAEGKEFS YYNSFLIADR NEAWILETSG KYWAAERVQG
VRNISNQLSI TTKIDREHPD MRNYAKQRGW WDGKEEFDFT AAYSYIDTAA MMTSPSRYCQ
GYKLLDKHRG NITFETMMEI LRDRPSGINM KGEFLTTASM VSVLPQDPSL PCIHLFTATP
HPERSVFKPF IFVPHISPLL DTKSPTFEPE RPVAKKPYVK PDRRHPLYQK HQEALEMISN
SKEKGKTILD KMRKLEKAVS EEIESILQSG HLDEEKTVNL FPQYVKDEIK IYQSNISS
