ID   SCRR_KLEPN              Reviewed;         334 AA.
AC   P37076;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Sucrose operon repressor;
DE   AltName: Full=Scr operon regulatory protein;
GN   Name=scrR;
OS   Klebsiella pneumoniae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=573;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=1033-5P14 / KAY2026;
RX   PubMed=8412665; DOI=10.1111/j.1365-2958.1993.tb01681.x;
RA   Jahreis K., Lengeler J.W.;
RT   "Molecular analysis of two ScrR repressors and of a ScrR-FruR hybrid
RT   repressor for sucrose and D-fructose specific regulons from enteric
RT   bacteria.";
RL   Mol. Microbiol. 9:195-209(1993).
CC   -!- FUNCTION: Repressor for the scr operon. Binds D-fructose as an inducer.
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DR   EMBL; X67751; CAA47977.1; -; Genomic_DNA.
DR   PIR; S35015; S35015.
DR   RefSeq; WP_004177008.1; NZ_WWEY01000152.1.
DR   AlphaFoldDB; P37076; -.
DR   SMR; P37076; -.
DR   GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:UniProt.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0009750; P:response to fructose; IEA:InterPro.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR012781; Fruct_sucro_rep.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR025997; SBP_2_dom.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF13407; Peripla_BP_4; 1.
DR   PRINTS; PR00036; HTHLACI.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   TIGRFAMs; TIGR02417; fruct_sucro_rep; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   4: Predicted;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..334
FT                   /note="Sucrose operon repressor"
FT                   /id="PRO_0000107999"
FT   DOMAIN          6..63
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        8..27
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
SQ   SEQUENCE   334 AA;  37186 MW;  F34CDC7505F747FE CRC64;
     MKTKRVTIKD IAELAGVSKA TASLVLNGRG KELRVAQETR ERVLAIAREQ HYQPSIHARS
     LRDNRSHTIG LVVPEITNYG FAVFSHELET LCREAGVQLL ISCTDENPGQ ESVVVNNMIA
     RQVDGLIVAS CMHSDADYQK LSEQLPVVLF DRSPSDSALP LVMTDSVTPT AELISRIAPQ
     HADEFWFLGG QPRLSPSRDR LAGFTQGLAQ AGITLRPEWV INGNYHPSSG YEMFAALCAR
     LGRPPKALFT AACGLLEGVL RYMSQHHLLD SNIHLASFDD HYLYDSLSLR IDTVQQDNRQ
     LAWHCYDLLS QLIDGQAPEP LQRYLPATLQ IRHP