ID   SCRR_SALTM              Reviewed;         334 AA.
AC   P37077;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Sucrose operon repressor;
DE   AltName: Full=Scr operon regulatory protein;
GN   Name=scrR;
OS   Salmonella typhimurium.
OG   Plasmid pUR400.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90371;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8412665; DOI=10.1111/j.1365-2958.1993.tb01681.x;
RA   Jahreis K., Lengeler J.W.;
RT   "Molecular analysis of two ScrR repressors and of a ScrR-FruR hybrid
RT   repressor for sucrose and D-fructose specific regulons from enteric
RT   bacteria.";
RL   Mol. Microbiol. 9:195-209(1993).
CC   -!- FUNCTION: Repressor for the scr operon. Binds D-fructose as an inducer.
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DR   EMBL; X67750; CAA47975.1; -; Genomic_DNA.
DR   PIR; S35018; S35018.
DR   AlphaFoldDB; P37077; -.
DR   SMR; P37077; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0009750; P:response to fructose; IEA:InterPro.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR012781; Fruct_sucro_rep.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR046335; LacI/GalR-like_sensor.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF13377; Peripla_BP_3; 1.
DR   PRINTS; PR00036; HTHLACI.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   TIGRFAMs; TIGR02417; fruct_sucro_rep; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   4: Predicted;
KW   DNA-binding; Plasmid; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..334
FT                   /note="Sucrose operon repressor"
FT                   /id="PRO_0000108000"
FT   DOMAIN          6..63
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        8..27
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
SQ   SEQUENCE   334 AA;  37434 MW;  2D6A13E5DB74E6DE CRC64;
     MKTKRVTIKD IAEQAGVSKA TASLVLNGRG KELRVAQETR ERVLSIARKH HYQPSIHARS
     LRNNRSHTIG LVVPEITNHG FAVFAHELEM LCREAGVQLL ISCTDENPGQ ESVVVNNMIA
     RQVDGMIVAS CMHNDADYLK LSQQLPVVLF DRCPNESALP LVMTDSITPT AELISRIAPQ
     HSDEFWFLGG QARLSPSRDR LTGFTQGLAQ AGIALRPEWV INGNYHPSSG YEMFAALCAR
     LGRPPKALFT AACGLLEGVL RYMSQHHLLD SDIHLTSFDD HYLYDSLSLR IDTVQQDNRQ
     LAWHCYDLIS QLIEGDTPET LQRYLPATLQ FRHQ