ID   SCRR_STRMU              Reviewed;         320 AA.
AC   Q54430;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2002, sequence version 2.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=Sucrose operon repressor;
DE   AltName: Full=Scr operon regulatory protein;
GN   Name=scrR; OrderedLocusNames=SMU_1844;
OS   Streptococcus mutans serotype c (strain ATCC 700610 / UA159).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=210007;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=GS-5;
RX   PubMed=9673256; DOI=10.1128/iai.66.8.3736-3743.1998;
RA   Hiratsuka K., Wang B., Sato Y., Kuramitsu H.K.;
RT   "Regulation of sucrose-6-phosphate hydrolase activity in Streptococcus
RT   mutans: characterization of the scrR gene.";
RL   Infect. Immun. 66:3736-3743(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700610 / UA159;
RX   PubMed=12397186; DOI=10.1073/pnas.172501299;
RA   Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B.,
RA   Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S.,
RA   Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.;
RT   "Genome sequence of Streptococcus mutans UA159, a cariogenic dental
RT   pathogen.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002).
CC   -!- FUNCTION: Negative regulator of scrB expression.
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DR   EMBL; U46902; AAC31628.1; -; Genomic_DNA.
DR   EMBL; AE014133; AAN59466.1; -; Genomic_DNA.
DR   RefSeq; NP_722160.1; NC_004350.2.
DR   RefSeq; WP_002262659.1; NC_004350.2.
DR   AlphaFoldDB; Q54430; -.
DR   SMR; Q54430; -.
DR   STRING; 210007.SMU_1844; -.
DR   PRIDE; Q54430; -.
DR   EnsemblBacteria; AAN59466; AAN59466; SMU_1844.
DR   GeneID; 66818797; -.
DR   KEGG; smu:SMU_1844; -.
DR   PATRIC; fig|210007.7.peg.1646; -.
DR   eggNOG; COG1609; Bacteria.
DR   HOGENOM; CLU_037628_6_0_9; -.
DR   OMA; CVAVDFR; -.
DR   PhylomeDB; Q54430; -.
DR   Proteomes; UP000002512; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR046335; LacI/GalR-like_sensor.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF13377; Peripla_BP_3; 1.
DR   PRINTS; PR00036; HTHLACI.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   4: Predicted;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..320
FT                   /note="Sucrose operon repressor"
FT                   /id="PRO_0000108003"
FT   DOMAIN          1..57
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        5..24
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   CONFLICT        190
FT                   /note="G -> A (in Ref. 1; AAC31628)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        294
FT                   /note="V -> I (in Ref. 1; AAC31628)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        304
FT                   /note="T -> I (in Ref. 1; AAC31628)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   320 AA;  35626 MW;  83E7722246DD4D48 CRC64;
     MVAKLTDVAK LAGVSPTTVS RVINRKGYLS EKTITKVQAA MKTLGYKPNN LARSLQGKSA
     KLIGLIFPNI SHIFYSELIE YLEIELFKHG YKAIICNSQN NPDKERDYLE MLEANQVDGI
     ISSSHNLGID DYEKVSAPII AFDRNLAPNI PIVSSDNFEG GRMAAKLLKK HGCQHPIMIA
     GKDNSNSPTG LRQLGFKSVF AQAPIFHLSG ELSIIRKEME IKVILQNEKP DGIFLSDDMT
     AILTMKIANQ LNITIPHELK IIGYDGTHFV ENYYPYLTTI RQPIKDIAHL LVDVLLKKID
     HQDTPKDYIL PVGLLSGESV