SCRT2_HUMAN
ID SCRT2_HUMAN Reviewed; 307 AA.
AC Q9NQ03;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 13-APR-2004, sequence version 3.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Transcriptional repressor scratch 2;
DE AltName: Full=Scratch homolog 2 zinc finger protein;
GN Name=SCRT2; ORFNames=FP7030;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Wan D.F., Qin W.X., Zhou X.M., Zhang P.P., Jiang H.Q., Gu J.R.;
RT "Novel human cDNA clones with function of promoting mice NIH/3T3 cells'
RT growth.";
RL Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the snail C2H2-type zinc-finger protein family.
CC {ECO:0000305}.
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DR EMBL; AY129025; AAM98768.1; -; mRNA.
DR EMBL; AL121758; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS13006.1; -.
DR RefSeq; NP_149120.1; NM_033129.3.
DR AlphaFoldDB; Q9NQ03; -.
DR SMR; Q9NQ03; -.
DR BioGRID; 124568; 22.
DR STRING; 9606.ENSP00000246104; -.
DR iPTMnet; Q9NQ03; -.
DR PhosphoSitePlus; Q9NQ03; -.
DR BioMuta; SCRT2; -.
DR DMDM; 46397045; -.
DR MassIVE; Q9NQ03; -.
DR PaxDb; Q9NQ03; -.
DR PeptideAtlas; Q9NQ03; -.
DR PRIDE; Q9NQ03; -.
DR ProteomicsDB; 82051; -.
DR Antibodypedia; 23001; 38 antibodies from 12 providers.
DR DNASU; 85508; -.
DR Ensembl; ENST00000246104.7; ENSP00000246104.5; ENSG00000215397.4.
DR GeneID; 85508; -.
DR KEGG; hsa:85508; -.
DR MANE-Select; ENST00000246104.7; ENSP00000246104.5; NM_033129.4; NP_149120.1.
DR UCSC; uc002wec.3; human.
DR CTD; 85508; -.
DR GeneCards; SCRT2; -.
DR HGNC; HGNC:15952; SCRT2.
DR HPA; ENSG00000215397; Group enriched (brain, retina).
DR neXtProt; NX_Q9NQ03; -.
DR OpenTargets; ENSG00000215397; -.
DR PharmGKB; PA35016; -.
DR VEuPathDB; HostDB:ENSG00000215397; -.
DR eggNOG; KOG2462; Eukaryota.
DR GeneTree; ENSGT00940000154491; -.
DR HOGENOM; CLU_002678_42_3_1; -.
DR InParanoid; Q9NQ03; -.
DR OMA; HINNTYS; -.
DR OrthoDB; 1332418at2759; -.
DR PhylomeDB; Q9NQ03; -.
DR TreeFam; TF315515; -.
DR PathwayCommons; Q9NQ03; -.
DR SignaLink; Q9NQ03; -.
DR BioGRID-ORCS; 85508; 6 hits in 1087 CRISPR screens.
DR GenomeRNAi; 85508; -.
DR Pharos; Q9NQ03; Tdark.
DR PRO; PR:Q9NQ03; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9NQ03; protein.
DR Bgee; ENSG00000215397; Expressed in ganglionic eminence and 22 other tissues.
DR GO; GO:0000785; C:chromatin; ISS:BHF-UCL.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; ISS:BHF-UCL.
DR GO; GO:0070888; F:E-box binding; ISS:BHF-UCL.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISS:BHF-UCL.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:1902042; P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; ISS:BHF-UCL.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:BHF-UCL.
DR GO; GO:2001222; P:regulation of neuron migration; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR InterPro; IPR029794; SCRATCH1/2.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24388:SF81; PTHR24388:SF81; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..307
FT /note="Transcriptional repressor scratch 2"
FT /id="PRO_0000047038"
FT ZN_FING 155..177
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 186..208
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 212..234
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 240..262
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 268..291
FT /note="C2H2-type 5; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..20
FT /note="SNAG domain"
FT /evidence="ECO:0000250"
FT REGION 34..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 116..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 307 AA; 32584 MW; E9328725903F9C17 CRC64;
MPRSFLVKKI KGDGFQCSGV PAPTYHPLET AYVLPGARGP PGDNGYAPHR LPPSSYDADQ
KPGLELAPAE PAYPPAAPEE YSDPESPQSS LSARYFRGEA AVTDSYSMDA FFISDGRSRR
RRGGGGGDAG GSGDAGGAGG RAGRAGAQAG GGHRHACAEC GKTYATSSNL SRHKQTHRSL
DSQLARKCPT CGKAYVSMPA LAMHLLTHNL RHKCGVCGKA FSRPWLLQGH MRSHTGEKPF
GCAHCGKAFA DRSNLRAHMQ THSAFKHYRC RQCDKSFALK SYLHKHCEAA CAKAAEPPPP
TPAGPAS
