ID   SCRY1_OCTVU             Reviewed;         214 AA.
AC   P27013;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=S-crystallin 1;
GN   Name=OCTS1;
OS   Octopus vulgaris (Common octopus).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC   Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX   NCBI_TaxID=6645;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lens;
RX   PubMed=1627174;
RA   Lin C.-W., Chiou S.-H.;
RT   "Facile cloning and sequencing of S-crystallin genes from octopus lenses
RT   based on polymerase chain reaction.";
RL   Biochem. Int. 27:173-178(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7639695; DOI=10.1042/bj3090793;
RA   Chiou S.-H., Yu C.-W., Lin C.-W., Pan F.-M., Lu S.-F., Lee H.-J.,
RA   Chang G.-G.;
RT   "Octopus S-crystallins with endogenous glutathione S-transferase (GST)
RT   activity: sequence comparison and evolutionary relationships with authentic
RT   GST enzymes.";
RL   Biochem. J. 309:793-800(1995).
CC   -!- FUNCTION: S-crystallins are structural components of squids and octopi
CC       eye lens. Contains relatively little GST activity (1/1000 of that of
CC       mammalian GST enzyme).
CC   -!- TISSUE SPECIFICITY: Lens.
CC   -!- SIMILARITY: Belongs to the GST superfamily. {ECO:0000305}.
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DR   EMBL; X65543; CAA46511.1; -; mRNA.
DR   PIR; S56758; S56758.
DR   AlphaFoldDB; P27013; -.
DR   SMR; P27013; -.
DR   Proteomes; UP000515154; Genome assembly.
DR   GO; GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
DR   InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR   InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR   InterPro; IPR004046; GST_C.
DR   InterPro; IPR003083; S-crystallin.
DR   Pfam; PF14497; GST_C_3; 1.
DR   PRINTS; PR01269; SCRYSTALLIN.
DR   SUPFAM; SSF47616; SSF47616; 1.
DR   PROSITE; PS50405; GST_CTER; 1.
DR   PROSITE; PS50404; GST_NTER; 1.
PE   2: Evidence at transcript level;
KW   Eye lens protein; Reference proteome.
FT   CHAIN           1..214
FT                   /note="S-crystallin 1"
FT                   /id="PRO_0000185996"
FT   DOMAIN          2..79
FT                   /note="GST N-terminal"
FT   DOMAIN          81..214
FT                   /note="GST C-terminal"
SQ   SEQUENCE   214 AA;  25280 MW;  6F1FEE66179C5189 CRC64;
     MPSYTLHYFN HRGRARSAVC CSQLLVSSTM TADRVFRMGQ HEKQDAMSHD ANVGIGQQNP
     NSPEYAMARY LAREFGFHGR NNMEMARVDF ISDCFYDILD DYMRMYQDGN CRMMFQRSRD
     MSSSSEKRMR FQETCRRILP FMERTLEMYN GGSQYFMGDQ MTMADMMCYC ALENPLMEEP
     SMLSSYPKLM ALRNRVMNHS KMSSYLQRRC RTDF