ID   SCRY4_ENTDO             Reviewed;         215 AA.
AC   P27012;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=S-crystallin 4;
DE   AltName: Full=OL4;
OS   Enteroctopus dofleini (North Pacific giant octopus) (Octopus dofleini).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC   Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Enteroctopus.
OX   NCBI_TaxID=267067;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lens;
RX   PubMed=1721068; DOI=10.1016/s0021-9258(18)54416-1;
RA   Tomarev S.I., Zinovieva R.D., Piatigorsky J.;
RT   "Crystallins of the octopus lens. Recruitment from detoxification
RT   enzymes.";
RL   J. Biol. Chem. 266:24226-24231(1991).
CC   -!- FUNCTION: S-crystallins are structural components of squids and octopi
CC       eye lens. Contains relatively little if any GST activity.
CC   -!- TISSUE SPECIFICITY: Lens.
CC   -!- SIMILARITY: Belongs to the GST superfamily. {ECO:0000305}.
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DR   EMBL; M65187; AAA29389.1; -; mRNA.
DR   PIR; D41681; D41681.
DR   AlphaFoldDB; P27012; -.
DR   SMR; P27012; -.
DR   GO; GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
DR   GO; GO:0006749; P:glutathione metabolic process; IEA:InterPro.
DR   InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR   InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR   InterPro; IPR040079; Glutathione_S-Trfase.
DR   InterPro; IPR004045; Glutathione_S-Trfase_N.
DR   InterPro; IPR004046; GST_C.
DR   InterPro; IPR003083; S-crystallin.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   Pfam; PF14497; GST_C_3; 1.
DR   Pfam; PF02798; GST_N; 1.
DR   PRINTS; PR01269; SCRYSTALLIN.
DR   SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR   SUPFAM; SSF47616; SSF47616; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   PROSITE; PS50405; GST_CTER; 1.
DR   PROSITE; PS50404; GST_NTER; 1.
PE   2: Evidence at transcript level;
KW   Eye lens protein.
FT   CHAIN           1..215
FT                   /note="S-crystallin 4"
FT                   /id="PRO_0000185995"
FT   DOMAIN          2..80
FT                   /note="GST N-terminal"
FT   DOMAIN          82..215
FT                   /note="GST C-terminal"
SQ   SEQUENCE   215 AA;  25675 MW;  86FCD9669E455948 CRC64;
     MPSYTLHYFN HRGRAEICRM LFAAAGVQYN DRRIESSEWG SMRSKMPCSM MPMLELDNKI
     QIPQSMAMAR YLAREFGFHG KNNMDMARVD YISDSFYDIL DDYMRMYHDK DGRMMFSRSK
     DMNSSSEKRM RYQETCRRIF PYLEKTLEMR NGGNQFFMGD QITMADMMCF CALENPLMED
     QNILRSYPKL QALRNRVINH PKMSAYLQKR SRTEF