ID   SCRY4_NOTSL             Reviewed;         302 AA.
AC   P27015;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=S-crystallin SL4;
DE   Flags: Fragment;
OS   Nototodarus sloanii (Wellington flying squid) (Ommastrephes sloanei).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC   Coleoidea; Decapodiformes; Teuthida; Oegopsina; Ommastrephidae;
OC   Nototodarus.
OX   NCBI_TaxID=215440;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1373730; DOI=10.1016/s0021-9258(18)42486-6;
RA   Tomarev S.I., Zinovieva R.D., Piatigorsky J.;
RT   "Characterization of squid crystallin genes. Comparison with mammalian
RT   glutathione S-transferase genes.";
RL   J. Biol. Chem. 267:8604-8612(1992).
CC   -!- FUNCTION: S-crystallins are structural components of squids and octopi
CC       eye lens.
CC   -!- SIMILARITY: Belongs to the GST superfamily. {ECO:0000305}.
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DR   EMBL; M74327; AAA91343.1; -; mRNA.
DR   PIR; A38100; A38100.
DR   AlphaFoldDB; P27015; -.
DR   SMR; P27015; -.
DR   GO; GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
DR   InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR   InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR   InterPro; IPR004046; GST_C.
DR   InterPro; IPR003083; S-crystallin.
DR   Pfam; PF14497; GST_C_3; 1.
DR   PRINTS; PR01269; SCRYSTALLIN.
DR   SUPFAM; SSF47616; SSF47616; 1.
DR   PROSITE; PS50405; GST_CTER; 1.
PE   2: Evidence at transcript level;
KW   Eye lens protein; Repeat.
FT   CHAIN           <1..302
FT                   /note="S-crystallin SL4"
FT                   /id="PRO_0000185999"
FT   REPEAT          45..54
FT                   /note="1"
FT   REPEAT          55..64
FT                   /note="2"
FT   REPEAT          65..74
FT                   /note="3"
FT   REPEAT          75..84
FT                   /note="4; approximate"
FT   DOMAIN          183..302
FT                   /note="GST C-terminal"
FT   REGION          45..84
FT                   /note="4 X approximate tandem repeats of G-G-Y-[AYP]-V-
FT                   [QK]-[SG]-R-G-D"
FT   REGION          68..92
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          118..205
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           52..54
FT                   /note="Cell attachment site"
FT                   /evidence="ECO:0000255"
FT   MOTIF           62..64
FT                   /note="Cell attachment site"
FT                   /evidence="ECO:0000255"
FT   MOTIF           72..74
FT                   /note="Cell attachment site"
FT                   /evidence="ECO:0000255"
FT   MOTIF           113..115
FT                   /note="Cell attachment site"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        133..205
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   302 AA;  34376 MW;  205D0E5A16895022 CRC64;
     CFYEIVDDYL RLFHDKEGRI MYDQMSDMRN RYIDMDGRMT FGTVGGYAVQ SRGDGGYYVK
     SRGDGGYPVQ GRGDTGYSSQ TRSDDACLGQ GRGEVDTGMS YDASTGVCTD INRGDMSSDI
     NSGLYSGGRM DDSCHTSESR RMDDPCGTDE SRRLDVPCHS DDHYRSDNPC TDDSCQAEDR
     RGGHSDSHRI DISSEESASR RSRNHAFAEG RMSEMRLRYM ETCRRVLPFM ERTLEMQHGG
     DTFFCGDEMM LCDMMCYCAL ENPLMENASF FGQYPKLMAL RERVASQINI SQYIKRRYQS
     DF