ID   SCR_ANEVI               Reviewed;          64 AA.
AC   P0DL61;
DT   14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2015, sequence version 1.
DT   25-MAY-2022, entry version 12.
DE   RecName: Full=Small cysteine-rich protein {ECO:0000303|PubMed:25757852};
DE            Short=Avir_SCRiP {ECO:0000305};
DE            Short=SCRiP {ECO:0000303|PubMed:25757852};
DE   Flags: Precursor; Fragment;
OS   Anemonia viridis (Snakelocks anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Actiniidae; Anemonia.
OX   NCBI_TaxID=51769;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=19627569; DOI=10.1186/1471-2164-10-333;
RA   Sabourault C., Ganot P., Deleury E., Allemand D., Furla P.;
RT   "Comprehensive EST analysis of the symbiotic sea anemone, Anemonia
RT   viridis.";
RL   BMC Genomics 10:333-333(2009).
RN   [2]
RP   FAMILY.
RX   PubMed=25757852; DOI=10.1093/molbev/msv050;
RA   Jouiaei M., Sunagar K., Federman Gross A., Scheib H., Alewood P.F.,
RA   Moran Y., Fry B.G.;
RT   "Evolution of an ancient venom: recognition of a novel family of cnidarian
RT   toxins and the common evolutionary origin of sodium and potassium
RT   neurotoxins in sea anemone.";
RL   Mol. Biol. Evol. 32:1598-1610(2015).
CC   -!- FUNCTION: Induces neurotoxic symptoms on zebrafish (By similarity).
CC       {ECO:0000250|UniProtKB:C0H691, ECO:0000250|UniProtKB:C0H692}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Nematocyst {ECO:0000305}.
CC   -!- PTM: Contains 4 disulfide bonds. {ECO:0000305}.
CC   -!- MISCELLANEOUS: This protein indicates that the SCRiP family is also
CC       present in Actiniaria (sea anemones) and not only in Scleractinia
CC       (stony corals). This family has firstly been claimed to be implied in
CC       calcification, however, as this family is also present in sea anemones
CC       and that they are not calcified, this function seems improbable.
CC       {ECO:0000305|PubMed:25757852}.
CC   -!- SIMILARITY: Belongs to the Cnidaria small cysteine-rich protein (SCRiP)
CC       family. {ECO:0000305|PubMed:25757852}.
CC   -!- CAUTION: Opinions are divided on whether Anemonia viridis (Forsskal,
CC       1775) and Anemonia sulcata (Pennant, 1777) are separate species.
CC       {ECO:0000305}.
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DR   EMBL; FK725749; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; P0DL61; -.
DR   SMR; P0DL61; -.
DR   PRIDE; P0DL61; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Nematocyst; Neurotoxin;
KW   Secreted; Signal; Toxin.
FT   SIGNAL          <1..17
FT                   /evidence="ECO:0000305"
FT   PROPEP          18..19
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000434293"
FT   CHAIN           22..64
FT                   /note="Small cysteine-rich protein"
FT                   /evidence="ECO:0000305|PubMed:19627569"
FT                   /id="PRO_0000434294"
FT   NON_TER         1
SQ   SEQUENCE   64 AA;  7209 MW;  E3B94ED700069065 CRC64;
     FVCVQARQID PEQILRTPEK RASCSSRGGI CRSTSIGCPR RYHSCHLFHH CRSHGDSCCC
     PNYG