ID   SCR_METSE               Reviewed;          69 AA.
AC   P0DL60;
DT   14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2015, sequence version 1.
DT   25-MAY-2022, entry version 8.
DE   RecName: Full=Small cysteine-rich protein {ECO:0000303|PubMed:25757852};
DE            Short=Msen-SCRiP {ECO:0000305};
DE            Short=SCRiP {ECO:0000303|PubMed:25757852};
DE   Flags: Precursor;
OS   Metridium senile (Brown sea anemone) (Frilled sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Nynantheae; Metridiidae; Metridium.
OX   NCBI_TaxID=6116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Richardson P., Lucas S., Rokhsar D., Wang M., Lindquist E.A.;
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FAMILY.
RX   PubMed=25757852; DOI=10.1093/molbev/msv050;
RA   Jouiaei M., Sunagar K., Federman Gross A., Scheib H., Alewood P.F.,
RA   Moran Y., Fry B.G.;
RT   "Evolution of an ancient venom: recognition of a novel family of cnidarian
RT   toxins and the common evolutionary origin of sodium and potassium
RT   neurotoxins in sea anemone.";
RL   Mol. Biol. Evol. 32:1598-1610(2015).
CC   -!- FUNCTION: Induces neurotoxic symptoms on zebrafish (By similarity).
CC       {ECO:0000250|UniProtKB:C0H691, ECO:0000250|UniProtKB:C0H692}.
CC   -!- SUBCELLULAR LOCATION: Secreted. Nematocyst {ECO:0000305}.
CC   -!- PTM: Contains 4 disulfide bonds. {ECO:0000305}.
CC   -!- MISCELLANEOUS: This protein indicates that the SCRiP family is also
CC       present in Actiniaria (sea anemones) and not only in Scleractinia
CC       (stony corals). This family has firstly been claimed to be implied in
CC       calcification, however, as this family is also present in sea anemones
CC       and that they are not calcified, this function seems improbable.
CC       {ECO:0000305|PubMed:25757852}.
CC   -!- SIMILARITY: Belongs to the Cnidaria small cysteine-rich protein (SCRiP)
CC       family. {ECO:0000305|PubMed:25757852}.
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DR   EMBL; FC835414; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; P0DL60; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Disulfide bond; Nematocyst; Neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..22
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000434291"
FT   CHAIN           25..69
FT                   /note="Small cysteine-rich protein"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000434292"
SQ   SEQUENCE   69 AA;  7944 MW;  AE722FA5BAC0779F CRC64;
     MKLQLCLVLL LLGVLYVQSV PEKRNKPECN SYRGQCTYMG HPCPDHTFPC ETYFDCPAGP
     HERCCCYKD