ID   SCS1_MESMA              Reviewed;          60 AA.
AC   Q95P89; Q963F8;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Putative potassium channel blocker TXKS1;
DE   AltName: Full=BmTXKS1;
DE   Flags: Precursor;
OS   Mesobuthus martensii (Manchurian scorpion) (Buthus martensii).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Mesobuthus.
OX   NCBI_TaxID=34649;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND AMIDATION AT LYS-59.
RC   TISSUE=Venom gland;
RX   PubMed=11384716; DOI=10.1016/s0041-0101(01)00078-2;
RA   Zhu S.-Y., Li W.-X., Zeng X.-C.;
RT   "Precursor nucleotide sequence and genomic organization of BmTXKS1, a new
RT   scorpion toxin-like peptide from Buthus martensii Karsch.";
RL   Toxicon 39:1291-1296(2001).
CC   -!- FUNCTION: Inhibits potassium channels. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
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DR   EMBL; AF155369; AAK61819.1; -; mRNA.
DR   EMBL; AF380940; AAK58091.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q95P89; -.
DR   SMR; Q95P89; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR008911; Toxin_alpha-KTx_8/9.
DR   Pfam; PF05453; Toxin_6; 1.
PE   1: Evidence at protein level;
KW   Amidation; Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW   Potassium channel impairing toxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000250"
FT   CHAIN           29..59
FT                   /note="Putative potassium channel blocker TXKS1"
FT                   /id="PRO_0000035364"
FT   MOD_RES         59
FT                   /note="Lysine amide"
FT                   /evidence="ECO:0000305|PubMed:11384716"
FT   DISULFID        32..49
FT                   /evidence="ECO:0000250"
FT   DISULFID        35..55
FT                   /evidence="ECO:0000250"
FT   DISULFID        39..57
FT                   /evidence="ECO:0000250"
FT   CONFLICT        44..46
FT                   /note="KKV -> VKK (in Ref. 1; AAK58091)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   60 AA;  6523 MW;  7AB56F57328B11EC CRC64;
     MNRLTTIILM LIVINVIMDD ISESKVAAGI VCKVCKIICG MQGKKVNICK APIKCKCKKG