ID   SCT1B_MOUSE             Reviewed;         212 AA.
AC   Q9JL59;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 114.
DE   RecName: Full=Secreted and transmembrane protein 1b;
DE   AltName: Full=Protein K-12;
DE   Flags: Precursor;
GN   Name=Sectm1b; Synonyms=K12, Sectm1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH CD7, AND SUBCELLULAR LOCATION.
RC   TISSUE=Colon;
RX   PubMed=10652336; DOI=10.1074/jbc.275.5.3431;
RA   Lyman S.D., Escobar S., Rousseau A.-M., Armstrong A., Fanslow W.C.;
RT   "Identification of CD7 as a cognate of the human K12 (SECTM1) protein.";
RL   J. Biol. Chem. 275:3431-3437(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in thymocyte signaling. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CD7. {ECO:0000269|PubMed:10652336}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:10652336};
CC       Single-pass type I membrane protein {ECO:0000305|PubMed:10652336}.
CC       Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SECTM family. {ECO:0000305}.
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DR   EMBL; AF210700; AAF30406.1; -; mRNA.
DR   EMBL; BC010805; AAH10805.1; -; mRNA.
DR   AlphaFoldDB; Q9JL59; -.
DR   SMR; Q9JL59; -.
DR   STRING; 10090.ENSMUSP00000045748; -.
DR   GlyGen; Q9JL59; 4 sites.
DR   PhosphoSitePlus; Q9JL59; -.
DR   PRIDE; Q9JL59; -.
DR   ProteomicsDB; 255372; -.
DR   MGI; MGI:1929083; Sectm1b.
DR   eggNOG; ENOG502TM1B; Eukaryota.
DR   InParanoid; Q9JL59; -.
DR   PhylomeDB; Q9JL59; -.
DR   PRO; PR:Q9JL59; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; Q9JL59; protein.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; ISO:MGI.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:MGI.
DR   GO; GO:0005125; F:cytokine activity; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR033231; SECTM1.
DR   PANTHER; PTHR15123; PTHR15123; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Disulfide bond; Glycoprotein; Membrane; Reference proteome;
KW   Secreted; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..212
FT                   /note="Secreted and transmembrane protein 1b"
FT                   /id="PRO_0000022287"
FT   TOPO_DOM        29..160
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..181
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        182..212
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        56
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        85
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        114
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        130
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        38..55
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   212 AA;  23477 MW;  75113E877A2C5B87 CRC64;
     MLAYSVTSSG LFPRMLWALL LLAASLNAHN DVWDEPCCTE HEVSVNRGSR VVMACNISNN
     LRDVTIELVT SEKTSIIFNH TPPGNYSKDS WQLHIQGVQA QLVITDAQDK HSGNYSWKLH
     GFQAEFKNFN LTVNAADRQK TEDLPVTKVP DKPPTAVRTE VIIIIAIATT IIITGIGVFV
     WYKQFPVAPQ IQMSVPCLIH GSPGIPYLTL PP