ID   SCTC_PSESY              Reviewed;         701 AA.
AC   Q01723;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1999, sequence version 2.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Type 3 secretion system secretin {ECO:0000250|UniProtKB:Q01244, ECO:0000255|HAMAP-Rule:MF_02219};
DE            Short=T3SS secretin {ECO:0000250|UniProtKB:Q01244, ECO:0000255|HAMAP-Rule:MF_02219};
DE   AltName: Full=Hypersensitivity response secretion protein HrpH {ECO:0000305};
DE   Flags: Precursor;
GN   Name=sctC {ECO:0000250|UniProtKB:Q01244, ECO:0000255|HAMAP-Rule:MF_02219};
GN   Synonyms=hrpH {ECO:0000303|PubMed:1400238};
OS   Pseudomonas syringae pv. syringae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas; Pseudomonas syringae.
OX   NCBI_TaxID=321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND SUBCELLULAR LOCATION.
RC   STRAIN=Pss61;
RX   PubMed=1400238; DOI=10.1128/jb.174.21.6878-6885.1992;
RA   Huang H.-C., He S.Y., Bauer D.W., Collmer A.;
RT   "The Pseudomonas syringae pv. syringae 61 hrpH product, an envelope protein
RT   required for elicitation of the hypersensitive response in plants.";
RL   J. Bacteriol. 174:6878-6885(1992).
RN   [2]
RP   SEQUENCE REVISION.
RA   Deng W.-L.;
RL   Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Pss61;
RX   PubMed=7579617; DOI=10.1094/mpmi-8-0733;
RA   Huang H.-C., Lin R.-H., Chang C.-J., Collmer A., Deng W.-L.;
RT   "The complete hrp gene cluster of Pseudomonas syringae pv. syringae 61
RT   includes two blocks of genes required for harpinPss secretion that are
RT   arranged colinearly with Yersinia ysc homologs.";
RL   Mol. Plant Microbe Interact. 8:733-746(1995).
CC   -!- FUNCTION: Component of the type III secretion system (T3SS), also
CC       called injectisome, which is used to inject bacterial effector proteins
CC       into eukaryotic host cells. Forms a ring-shaped multimeric structure
CC       with an apparent central pore in the outer membrane (By similarity).
CC       Involved in the secretion of a proteinaceous elicitor of the
CC       hypersensitivity response in plants (PubMed:1400238).
CC       {ECO:0000255|HAMAP-Rule:MF_02219, ECO:0000269|PubMed:1400238}.
CC   -!- SUBUNIT: The core secretion machinery of the T3SS is composed of
CC       approximately 20 different proteins, including cytoplasmic components,
CC       a base, an export apparatus and a needle. This subunit is part of the
CC       base, which anchors the injectisome in the bacterial cell envelope.
CC       Forms a stable homooligomeric complex. {ECO:0000255|HAMAP-
CC       Rule:MF_02219}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC       Rule:MF_02219, ECO:0000305|PubMed:1400238}.
CC   -!- SIMILARITY: Belongs to the bacterial secretin family. T3SS SctC
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_02219, ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L01064; AAC05014.1; -; Genomic_DNA.
DR   EMBL; EF514224; AAB05085.2; -; Genomic_DNA.
DR   PIR; A45243; A45243.
DR   AlphaFoldDB; Q01723; -.
DR   TCDB; 1.B.22.3.1; the outer bacterial membrane secretin (secretin) family.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030257; C:type III protein secretion system complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0034053; P:modulation by symbiont of host defense-related programmed cell death; IEA:UniProtKB-KW.
DR   GO; GO:0030254; P:protein secretion by the type III secretion system; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.120; -; 2.
DR   HAMAP; MF_02219; Type_III_secretin; 1.
DR   InterPro; IPR005644; NolW-like.
DR   InterPro; IPR038591; NolW-like_sf.
DR   InterPro; IPR004846; T2SS/T3SS.
DR   InterPro; IPR004845; T2SS_GspD_CS.
DR   InterPro; IPR003522; T3SS_OM_pore_YscC.
DR   Pfam; PF00263; Secretin; 1.
DR   Pfam; PF03958; Secretin_N; 1.
DR   PRINTS; PR01337; TYPE3OMGPROT.
DR   TIGRFAMs; TIGR02516; type_III_yscC; 1.
DR   PROSITE; PS00875; T2SP_D; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Hypersensitive response elicitation; Membrane;
KW   Protein transport; Signal; Translocation; Transport.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02219"
FT   CHAIN           22..701
FT                   /note="Type 3 secretion system secretin"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02219"
FT                   /id="PRO_0000013108"
FT   REGION          229..252
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   701 AA;  76546 MW;  4F470B33B9D00025 CRC64;
     MRKALMWLPL LLIGLSPATW AVTPEAWKHT AYAYDARQTE LATALADFAK EFGMALDMPP
     IPGVLDDRIR AQSPEEFLDR LGQEYHFQWF VYNDTLYVSP SSEHTSARIE VSSDAVDDLQ
     TALTDVGLLD KRFGWGVLPN EGVVLVRGPA KYVELVRDYS KKVEAPEKGD KQDVIVFPLK
     YASAADRTIR YRDQQLVVAG VASILQDLLD TRSHGGSING MDLLGRGGRG NGLAGGGSPD
     TPSLPMSSSG LDTNALEQGL DQVLHYGGGG TKSSGKSRSG GRANIRVTAD VRNNAVLIYD
     LPSRKAMYEK LIKELDVSRN LIEIDAVILD IDRNELAELS SRWNFNAGSV NGGANMFDAG
     TSSTLFIQNA GKFAAELHAL EGNGSASVIG NPSILTLENQ PAVIDFSRTE YLTATSERVA
     NIEPITAGTS LQVTPRSLDH DGKPQVQLIV DIEDGQIDIS DINDTQPSVR KGNVSTQAVI
     AEHGSLVIGG FHGLEANDKV HKVPLLGDIP YIGKLLFQSR SRELSQRERL FILTPRLIGD
     QVNPARYVQN GNPHDVDDQM KRIKERRDGG ELPTRGDIQK VFTQMVDGAA PEGMHDGETL
     PFETDSLCDP GQGLSLDGQR SQWYARKDWG VAVVVARNNT DKPVRIDESR CGGRWVIGVA
     AWPHAWLQPG EESEVYIAVR QPQISKMAKE SRPSLLRGAK P