SCTC_RALSO
ID SCTC_RALSO Reviewed; 568 AA.
AC Q52498;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 126.
DE RecName: Full=Type 3 secretion system secretin {ECO:0000250|UniProtKB:Q01244, ECO:0000255|HAMAP-Rule:MF_02219};
DE Short=T3SS secretin {ECO:0000250|UniProtKB:Q01244, ECO:0000255|HAMAP-Rule:MF_02219};
DE AltName: Full=Hypersensitivity response secretion protein HrpA;
DE Flags: Precursor;
GN Name=sctC {ECO:0000250|UniProtKB:Q01244, ECO:0000255|HAMAP-Rule:MF_02219};
GN Synonyms=hrcC {ECO:0000303|PubMed:7623665},
GN hrpA {ECO:0000303|PubMed:1472716}; OrderedLocusNames=RSp0874;
GN ORFNames=RS01645;
OS Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum).
OG Plasmid megaplasmid Rsp.
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Ralstonia.
OX NCBI_TaxID=267608;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=GMI1000;
RX PubMed=1472716; DOI=10.1094/mpmi-5-384;
RA Gough C.L., Genin S., Zischek C., Boucher C.A.;
RT "hrp genes of Pseudomonas solanacearum are homologous to pathogenicity
RT determinants of animal pathogenic bacteria and are conserved among plant
RT pathogenic bacteria.";
RL Mol. Plant Microbe Interact. 5:384-389(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=GMI1000;
RX PubMed=7623665; DOI=10.1111/j.1365-2958.1995.tb02284.x;
RA van Gijsegem F., Gough C.L., Zischek C., Niqueux E., Arlat M., Genin S.,
RA Barberis P., German S., Castello P., Boucher C.A.;
RT "The hrp gene locus of Pseudomonas solanacearum, which controls the
RT production of a type III secretion system, encodes eight proteins related
RT to components of the bacterial flagellar biogenesis complex.";
RL Mol. Microbiol. 15:1095-1114(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GMI1000;
RX PubMed=11823852; DOI=10.1038/415497a;
RA Salanoubat M., Genin S., Artiguenave F., Gouzy J., Mangenot S., Arlat M.,
RA Billault A., Brottier P., Camus J.-C., Cattolico L., Chandler M.,
RA Choisne N., Claudel-Renard C., Cunnac S., Demange N., Gaspin C., Lavie M.,
RA Moisan A., Robert C., Saurin W., Schiex T., Siguier P., Thebault P.,
RA Whalen M., Wincker P., Levy M., Weissenbach J., Boucher C.A.;
RT "Genome sequence of the plant pathogen Ralstonia solanacearum.";
RL Nature 415:497-502(2002).
CC -!- FUNCTION: Component of the type III secretion system (T3SS), also
CC called injectisome, which is used to inject bacterial effector proteins
CC into eukaryotic host cells. Forms a ring-shaped multimeric structure
CC with an apparent central pore in the outer membrane.
CC {ECO:0000255|HAMAP-Rule:MF_02219}.
CC -!- SUBUNIT: The core secretion machinery of the T3SS is composed of
CC approximately 20 different proteins, including cytoplasmic components,
CC a base, an export apparatus and a needle. This subunit is part of the
CC base, which anchors the injectisome in the bacterial cell envelope.
CC Forms a stable homooligomeric complex. {ECO:0000255|HAMAP-
CC Rule:MF_02219}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC Rule:MF_02219}.
CC -!- SIMILARITY: Belongs to the bacterial secretin family. T3SS SctC
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_02219, ECO:0000305}.
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DR EMBL; AJ245811; CAB58261.1; -; Genomic_DNA.
DR EMBL; M99361; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL646053; CAD18025.1; -; Genomic_DNA.
DR RefSeq; WP_011004171.1; NC_003296.1.
DR AlphaFoldDB; Q52498; -.
DR SMR; Q52498; -.
DR STRING; 267608.RSp0874; -.
DR EnsemblBacteria; CAD18025; CAD18025; RSp0874.
DR GeneID; 60503782; -.
DR KEGG; rso:RSp0874; -.
DR PATRIC; fig|267608.8.peg.4344; -.
DR eggNOG; COG1450; Bacteria.
DR HOGENOM; CLU_022474_2_0_4; -.
DR OMA; YLMARIS; -.
DR Proteomes; UP000001436; Plasmid megaplasmid Rsp.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030257; C:type III protein secretion system complex; IEA:UniProtKB-UniRule.
DR GO; GO:0034053; P:modulation by symbiont of host defense-related programmed cell death; IEA:UniProtKB-KW.
DR GO; GO:0030254; P:protein secretion by the type III secretion system; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1370.120; -; 2.
DR HAMAP; MF_02219; Type_III_secretin; 1.
DR InterPro; IPR005644; NolW-like.
DR InterPro; IPR038591; NolW-like_sf.
DR InterPro; IPR004846; T2SS/T3SS.
DR InterPro; IPR004845; T2SS_GspD_CS.
DR InterPro; IPR003522; T3SS_OM_pore_YscC.
DR Pfam; PF00263; Secretin; 1.
DR Pfam; PF03958; Secretin_N; 2.
DR PRINTS; PR01337; TYPE3OMGPROT.
DR TIGRFAMs; TIGR02516; type_III_yscC; 1.
DR PROSITE; PS00875; T2SP_D; 1.
PE 3: Inferred from homology;
KW Cell outer membrane; Hypersensitive response elicitation; Membrane;
KW Plasmid; Protein transport; Reference proteome; Signal; Translocation;
KW Transport; Virulence.
FT SIGNAL 1..15
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02219"
FT CHAIN 16..568
FT /note="Type 3 secretion system secretin"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02219"
FT /id="PRO_0000013109"
FT REGION 203..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..288
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 568 AA; 60440 MW; 35B2640E9C97FF7B CRC64;
MAAALLLWTA GTVCAAPIPW QSQKFEYVAD RKDIKEVLRD LGASQHVMTS ISTQVEGSVT
GSFNETPQKF LDRMAGTFGF AWYYDGAVLR VTSANEAQSA TIALTRASTA QVKRALTRMG
IADSRFPIQY DDDSGSIVVS GPPRLVELVR DIAQVIDRGR EDANRTVVRA FPLRYAWATD
HRVTVNGQSV NIRGVASILN SMYGGDGPSD SGTAPRAQDR RLDSVAPGEA SAGRAGTRAL
SSLGGGKSPL PPGGTGQYVG NSGPYAPPPS GENRLRSDEL DDRGSTPIIR ADPRSNSVLV
RDRADRMAAH QSLIESLDSR PAVLEISASI IDISENALEQ LGVDWRLHNS RFDLQTGNGT
NTMLNNPGSL DSVATTAGAA AAIAATPAGG VLSAVIGGGS RYLMARISAL QQTDQARITA
NPKVATLDNT EAVMDNRQNF YVPVAGYQSA DLYAISAGVS LRVLPMVVMD GGTVRIRMNV
HIEDGQITSQ QVGNLPITSQ SEIDTQALIN EGDSLLIAGY SVEQQSKSVD AVPGLSKIPL
VGALFRTDQT TGKRFQRMFL VTPRVITP