ID   SCTC_SHISO              Reviewed;         566 AA.
AC   Q55293;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Type 3 secretion system secretin {ECO:0000250|UniProtKB:Q04641, ECO:0000255|HAMAP-Rule:MF_02219};
DE            Short=T3SS secretin {ECO:0000250|UniProtKB:Q04641, ECO:0000255|HAMAP-Rule:MF_02219};
DE   AltName: Full=Outer membrane protein MxiD {ECO:0000305};
DE   Flags: Precursor;
GN   Name=sctC {ECO:0000250|UniProtKB:Q04641, ECO:0000255|HAMAP-Rule:MF_02219};
GN   Synonyms=mxiD;
OS   Shigella sonnei.
OG   Plasmid.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=624;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=HW383;
RA   Arakawa E., Kato J., Ito K., Watanabe H.;
RT   "Comparison and high conservation of nucleotide sequences of spa-mxi
RT   regions between S.sonnei and S.flexneri -- identification of a new gene
RT   coding plausible membrane protein.";
RL   Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the type III secretion system (T3SS), also
CC       called injectisome, which is used to inject bacterial effector proteins
CC       into eukaryotic host cells. Forms a ring-shaped multimeric structure
CC       with an apparent central pore in the outer membrane.
CC       {ECO:0000255|HAMAP-Rule:MF_02219}.
CC   -!- SUBUNIT: The core secretion machinery of the T3SS is composed of
CC       approximately 20 different proteins, including cytoplasmic components,
CC       a base, an export apparatus and a needle. This subunit is part of the
CC       base, which anchors the injectisome in the bacterial cell envelope.
CC       Forms a stable homooligomeric complex. {ECO:0000255|HAMAP-
CC       Rule:MF_02219}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC       Rule:MF_02219}.
CC   -!- SIMILARITY: Belongs to the bacterial secretin family. T3SS SctC
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_02219, ECO:0000305}.
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DR   EMBL; D50601; BAA09154.1; -; Genomic_DNA.
DR   RefSeq; WP_050899888.1; NZ_WHSK01000249.1.
DR   AlphaFoldDB; Q55293; -.
DR   BMRB; Q55293; -.
DR   SMR; Q55293; -.
DR   STRING; 216599.GCA_000283715_05236; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030257; C:type III protein secretion system complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0030254; P:protein secretion by the type III secretion system; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.120; -; 2.
DR   HAMAP; MF_02219; Type_III_secretin; 1.
DR   InterPro; IPR005644; NolW-like.
DR   InterPro; IPR038591; NolW-like_sf.
DR   InterPro; IPR004846; T2SS/T3SS.
DR   InterPro; IPR004845; T2SS_GspD_CS.
DR   InterPro; IPR003522; T3SS_OM_pore_YscC.
DR   Pfam; PF00263; Secretin; 1.
DR   Pfam; PF03958; Secretin_N; 1.
DR   PRINTS; PR01337; TYPE3OMGPROT.
DR   TIGRFAMs; TIGR02516; type_III_yscC; 1.
DR   PROSITE; PS00875; T2SP_D; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Plasmid; Protein transport; Signal;
KW   Translocation; Transport; Virulence.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02219"
FT   CHAIN           23..566
FT                   /note="Type 3 secretion system secretin"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02219"
FT                   /id="PRO_0000013113"
SQ   SEQUENCE   566 AA;  63145 MW;  F9B0CE710DE4553D CRC64;
     MKKFNIKSLT LLIVLLPLIV NANNIDSHLL EQNDIAKYVA QSDTVGSFFD RFSALLNYPI
     VVSKQAAKKR ISGEFDLSNP EEMLEKLTLL VGLIWYKDGN ALYIYDSGEL ISKVILLENI
     SLNYLIQYLK DANLYDHRYP IRGNISDKTF YISGPPALVE LVANTATLLD KQVSSIGTDK
     VNFGVIKLKN TFVSDRTYNM RGEDIVIPGV ATVVERLLNN GKALSNRQAQ NDPMPPFNIT
     QKVSEDSNDF SFSSVTNSSI LEDVSLIAYP ETNSILVKGN DQQIQIIRDI ITQLDVAKRH
     IELSLWIIDI DKSELNNLGV NWQGTASFGD SFGASFNMSS SASISTLDGN KFIASVMALN
     QKKKANVVSR PVILTQENIP AIFDNNRTFY VSLVGERNSS LEHVTYGTLI NVIPRFSSRG
     QIEMSLTIED GTGNSQSNYN YNNENTSVLP EVGRTKISTI ARVPQGKSLL IGGYTHETNS
     NEIVSIPFLS SIPVIGNVFK YKTSNISNIV RVFLIQPREI KESSYYNTAE YKSLISEREI
     QKTTQIIPSE TTLLEDEKSL VSYLNY