ID   SCTC_XANEU              Reviewed;         607 AA.
AC   P80151;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Type 3 secretion system secretin {ECO:0000250|UniProtKB:Q01244, ECO:0000255|HAMAP-Rule:MF_02219};
DE            Short=T3SS secretin {ECO:0000250|UniProtKB:Q01244, ECO:0000255|HAMAP-Rule:MF_02219};
DE   AltName: Full=Hypersensitivity response secretion protein HrpA1;
DE   Flags: Precursor;
GN   Name=sctC {ECO:0000250|UniProtKB:Q01244, ECO:0000255|HAMAP-Rule:MF_02219};
GN   Synonyms=hrpA1;
OS   Xanthomonas euvesicatoria.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Xanthomonas.
OX   NCBI_TaxID=456327;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=Isolate 75-3;
RX   PubMed=1472717; DOI=10.1094/mpmi-5-390;
RA   Fenselau S., Balbo I., Bonas U.;
RT   "Determinants of pathogenicity in Xanthomonas campestris pv. vesicatoria
RT   are related to proteins involved in secretion in bacterial pathogens of
RT   animals.";
RL   Mol. Plant Microbe Interact. 5:390-396(1992).
CC   -!- FUNCTION: Component of the type III secretion system (T3SS), also
CC       called injectisome, which is used to inject bacterial effector proteins
CC       into eukaryotic host cells. Forms a ring-shaped multimeric structure
CC       with an apparent central pore in the outer membrane (By similarity).
CC       Necessary for both basic pathogenicity and the induction of the
CC       hypersensitive response in resistant plants (PubMed:1472717).
CC       {ECO:0000255|HAMAP-Rule:MF_02219, ECO:0000269|PubMed:1472717}.
CC   -!- SUBUNIT: The core secretion machinery of the T3SS is composed of
CC       approximately 20 different proteins, including cytoplasmic components,
CC       a base, an export apparatus and a needle. This subunit is part of the
CC       base, which anchors the injectisome in the bacterial cell envelope.
CC       Forms a stable homooligomeric complex. {ECO:0000255|HAMAP-
CC       Rule:MF_02219}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC       Rule:MF_02219}.
CC   -!- SIMILARITY: Belongs to the bacterial secretin family. T3SS SctC
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_02219, ECO:0000305}.
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DR   EMBL; M99173; AAA27603.1; -; Genomic_DNA.
DR   EMBL; U33548; AAB08464.1; -; Genomic_DNA.
DR   RefSeq; WP_011346107.1; NZ_QFAL01000063.1.
DR   AlphaFoldDB; P80151; -.
DR   PATRIC; fig|456327.29.peg.3427; -.
DR   OMA; MDNTTRF; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030257; C:type III protein secretion system complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0034053; P:modulation by symbiont of host defense-related programmed cell death; IEA:UniProtKB-KW.
DR   GO; GO:0030254; P:protein secretion by the type III secretion system; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.120; -; 2.
DR   HAMAP; MF_02219; Type_III_secretin; 1.
DR   InterPro; IPR005644; NolW-like.
DR   InterPro; IPR038591; NolW-like_sf.
DR   InterPro; IPR004846; T2SS/T3SS.
DR   InterPro; IPR004845; T2SS_GspD_CS.
DR   InterPro; IPR003522; T3SS_OM_pore_YscC.
DR   Pfam; PF00263; Secretin; 1.
DR   Pfam; PF03958; Secretin_N; 1.
DR   PRINTS; PR01337; TYPE3OMGPROT.
DR   TIGRFAMs; TIGR02516; type_III_yscC; 1.
DR   PROSITE; PS00875; T2SP_D; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Hypersensitive response elicitation; Membrane;
KW   Protein transport; Signal; Translocation; Transport; Virulence.
FT   SIGNAL          1..33
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02219"
FT   CHAIN           34..607
FT                   /note="Type 3 secretion system secretin"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02219"
FT                   /id="PRO_0000013110"
FT   REGION          277..332
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   607 AA;  63936 MW;  E6C6337C864F9308 CRC64;
     MAPACTTAHR RRAPLAAVLM LSLLPLLSPH ADAAQVPWHS RTFKYVADNK DLKEVLRDLS
     ASQSIATWIS PEVTGTLSGK FETSPQEFLD DLAATYGFVW YYDGAVLRIW GANESKSATL
     SLGTASTKSL RDALARMRLD DPRFPVRYDE AAHVAVVSGP PGYVDTVSAI AKQVEQGARQ
     RDATEVQVFQ LHYAQAADHT TRIGGQDVQI PGMASLLRSM YGARGAPVAA IPGPGANFGR
     VQPIGGGSSN TFGNAAQGQG GGASGILGLP SSWFGGASSS DRVPVSPPLP GSGAAAAAGS
     PASVWPELSK GRRDESNPID AGGGAELASD APVIEADPRT NAILIRDRPE RMQSYGTLIQ
     QLDNRPKLLQ IDATIIEIRD GAMQDLGVDW RFHSQHTDIQ TGDGRGGQLG FNGALSGAAT
     DGATTPVGGT LTAVLGDAGR YLMTRVSALE TTNKAKIVSS PQVATLDNVE AVMDHKQQAF
     VRVSGYASAD LYNLSAGVSL RVLPSVVPGS PNGQMRLDVR IEDGQLGSNT VDGIPVITSS
     EITTQAFVNE GQSLLIAGYA YDADETDLNA IPGLSKIPLV GNLFKHRQKS GTRMQRLFLL
     TPHVVSP