SCTC_YERPE
ID SCTC_YERPE Reviewed; 607 AA.
AC Q56974; A0A0H2W163; Q74YX8; Q7BTX6;
DT 18-SEP-2019, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 172.
DE RecName: Full=Type 3 secretion system secretin {ECO:0000255|HAMAP-Rule:MF_02219, ECO:0000305};
DE Short=T3SS secretin {ECO:0000255|HAMAP-Rule:MF_02219, ECO:0000305};
DE AltName: Full=Type III secretion protein YscC {ECO:0000303|PubMed:15721783};
DE Flags: Precursor;
GN Name=sctC {ECO:0000250|UniProtKB:Q01244, ECO:0000255|HAMAP-Rule:MF_02219};
GN Synonyms=yscC {ECO:0000303|PubMed:1624469};
GN OrderedLocusNames=YPCD1.52 {ECO:0000312|EMBL:CAB54929.1};
OS Yersinia pestis.
OG Plasmid pCD1.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND INDUCTION.
RC STRAIN=KIM5 / Biovar Mediaevalis;
RX PubMed=1624469; DOI=10.1128/jb.174.14.4820-4828.1992;
RA Haddix P.L., Straley S.C.;
RT "Structure and regulation of the Yersinia pestis yscBCDEF operon.";
RL J. Bacteriol. 174:4820-4828(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=KIM5 / Biovar Mediaevalis;
RX PubMed=9746557; DOI=10.1128/iai.66.10.4611-4623.1998;
RA Perry R.D., Straley S.C., Fetherston J.D., Rose D.J., Gregor J.,
RA Blattner F.R.;
RT "DNA sequencing and analysis of the low-Ca2+-response plasmid pCD1 of
RT Yersinia pestis KIM5.";
RL Infect. Immun. 66:4611-4623(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=KIM5 / Biovar Mediaevalis;
RX PubMed=9748454; DOI=10.1128/jb.180.19.5192-5202.1998;
RA Hu P., Elliott J., McCready P., Skowronski E., Garnes J., Kobayashi A.,
RA Brubaker R.R., Garcia E.;
RT "Structural organization of virulence-associated plasmids of Yersinia
RT pestis.";
RL J. Bacteriol. 180:5192-5202(1998).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C790;
RX PubMed=21197443; DOI=10.1155/2010/760819;
RA Rajanna C., Revazishvili T., Rashid M.H., Chubinidze S., Bakanidze L.,
RA Tsanava S., Imnadze P., Bishop-Lilly K.A., Sozhamannan S., Gibbons H.S.,
RA Morris J.G., Sulakvelidze A.;
RT "Characterization of pPCP1 plasmids in Yersinia pestis strains isolated
RT from the former Soviet Union.";
RL Int. J. Microbiol. 2010:760819-760819(2010).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=15721783; DOI=10.1016/j.pep.2004.11.001;
RA Goodin J.L., Raab R.W., McKown R.L., Coffman G.L., Powell B.S., Enama J.T.,
RA Ligon J.A., Andrews G.P.;
RT "Yersinia pestis outer membrane type III secretion protein YscC:
RT expression, purification, characterization, and induction of specific
RT antiserum.";
RL Protein Expr. Purif. 40:152-163(2005).
RN [7]
RP INTERACTION WITH YSCD/SCTD.
RC STRAIN=KIM5-3001;
RX PubMed=21357482; DOI=10.1128/jb.01137-10;
RA Ross J.A., Plano G.V.;
RT "A C-terminal region of Yersinia pestis YscD binds the outer membrane
RT secretin YscC.";
RL J. Bacteriol. 193:2276-2289(2011).
CC -!- FUNCTION: Component of the type III secretion system (T3SS), also
CC called injectisome, which is used to inject bacterial effector proteins
CC into eukaryotic host cells. Forms a ring-shaped multimeric structure
CC with an apparent central pore in the outer membrane.
CC {ECO:0000255|HAMAP-Rule:MF_02219}.
CC -!- SUBUNIT: The core secretion machinery of the T3SS is composed of
CC approximately 20 different proteins, including cytoplasmic components,
CC a base, an export apparatus and a needle. This subunit is part of the
CC base, which anchors the injectisome in the bacterial cell envelope.
CC Forms a stable homooligomeric complex (By similarity). Interacts with
CC the inner membrane ring inner protein YscD/SctD (PubMed:21357482).
CC {ECO:0000255|HAMAP-Rule:MF_02219, ECO:0000269|PubMed:21357482}.
CC -!- INTERACTION:
CC Q56974; Q56975: yscD; NbExp=2; IntAct=EBI-2861069, EBI-6413916;
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC Rule:MF_02219}.
CC -!- INDUCTION: Thermally induced and down-regulated in the presence of
CC calcium. {ECO:0000269|PubMed:1624469}.
CC -!- SIMILARITY: Belongs to the bacterial secretin family. T3SS SctC
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_02219, ECO:0000305}.
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DR EMBL; M83225; AAA27638.1; -; Genomic_DNA.
DR EMBL; AF074612; AAC69781.1; -; Genomic_DNA.
DR EMBL; AF053946; AAC62552.1; -; Genomic_DNA.
DR EMBL; HQ612242; ADV16646.1; -; Genomic_DNA.
DR EMBL; AL117189; CAB54929.1; -; Genomic_DNA.
DR PIR; T43573; T43573.
DR RefSeq; NP_395186.1; NC_003131.1.
DR RefSeq; NP_857730.1; NC_004836.1.
DR RefSeq; NP_857925.1; NC_004839.1.
DR RefSeq; WP_002212923.1; NZ_WUCM01000070.1.
DR AlphaFoldDB; Q56974; -.
DR SMR; Q56974; -.
DR IntAct; Q56974; 2.
DR STRING; 214092.5832472; -.
DR KEGG; ype:YPCD1.52; -.
DR PATRIC; fig|214092.21.peg.61; -.
DR eggNOG; COG1450; Bacteria.
DR HOGENOM; CLU_022474_3_0_6; -.
DR Proteomes; UP000000815; Plasmid pCD1.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015627; C:type II protein secretion system complex; IBA:GO_Central.
DR GO; GO:0030257; C:type III protein secretion system complex; IEA:UniProtKB-UniRule.
DR GO; GO:0009306; P:protein secretion; IBA:GO_Central.
DR GO; GO:0030254; P:protein secretion by the type III secretion system; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1370.120; -; 2.
DR HAMAP; MF_02219; Type_III_secretin; 1.
DR InterPro; IPR005644; NolW-like.
DR InterPro; IPR038591; NolW-like_sf.
DR InterPro; IPR004846; T2SS/T3SS.
DR InterPro; IPR004845; T2SS_GspD_CS.
DR InterPro; IPR003522; T3SS_OM_pore_YscC.
DR Pfam; PF00263; Secretin; 1.
DR Pfam; PF03958; Secretin_N; 1.
DR PRINTS; PR01337; TYPE3OMGPROT.
DR TIGRFAMs; TIGR02516; type_III_yscC; 1.
DR PROSITE; PS00875; T2SP_D; 1.
PE 1: Evidence at protein level;
KW Cell outer membrane; Membrane; Plasmid; Protein transport;
KW Reference proteome; Signal; Translocation; Transport; Virulence.
FT SIGNAL 1..26
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02219"
FT CHAIN 27..607
FT /note="Type 3 secretion system secretin"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02219"
FT /id="PRO_5014105476"
SQ SEQUENCE 607 AA; 67345 MW; A8DA2AF1EFDB0883 CRC64;
MAFPLHSFFK RVLTGTLLLL SNYSWAQELD WLPIPYVYVA KGESLRDLLI DFSANYDATV
VVSDKINDKV SGQFEHDNPQ DFLQHIASLY NLVWYYDGNV LYIFKNSEVA SRLIRLQESE
AAELKLALQR SGIWEPRFGW RPDASNRLVY VSGPPRYLEL VEQTAAALEQ QTQIRSEKTG
ALAIEIFPLK YASASDRTIH YRDDEVAAPG VATILQRVLS DATIQQVTVD NQRIPQAATR
ASAQAKVEAD PSLNAIIVRD SPERMPMYQR LIHALDKPSA RIEVALSIVD INADQLTELG
VDWRVGIRTG NNHQVVIKTT GDQSNIASNG ALGSLIDARG LDYLLARVNL LENEGSAQVV
SRPTLLTQEN AQAVIDHHET YYVKVTGKEV AELKGITYGT MLRMTPRVLT QGDKSEISLN
LHIEDGNQKP NSSGIDGIPT ISRTVVDTVA RVGHGQSLII GGIYRDELSV ALSKVPLLGD
IPYLGALFRR KSELTRRTVR LFIIEPRIID EGIAHHLALG NGRDLRTGIL AVDEISNQST
TLNKLLGGFQ CQPLNKAQEV QKWLSQNNKS SYLTQCKMDK SLGWRVVEGA CTPAESWCVS
APKRGVL
