ID   SCTG_SALTS              Reviewed;         147 AA.
AC   E1WAE4; P37423;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 1.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=SPI-1 type 3 secretion system pilotin {ECO:0000305};
DE   AltName: Full=Invasion lipoprotein invH;
DE   Flags: Precursor;
GN   Name=invH {ECO:0000303|PubMed:8382333};
GN   Synonyms=sctG {ECO:0000250|UniProtKB:P0CL43};
GN   OrderedLocusNames=SL1344_2879;
OS   Salmonella typhimurium (strain SL1344).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=216597;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=SL1344;
RX   PubMed=8382333; DOI=10.1111/j.1365-2958.1993.tb01100.x;
RA   Altmeyer R.M., McNern J.K., Bossio J.C., Rosenshine I., Finlay B.B.,
RA   Galan J.E.;
RT   "Cloning and molecular characterization of a gene involved in Salmonella
RT   adherence and invasion of cultured epithelial cells.";
RL   Mol. Microbiol. 7:89-98(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SL1344;
RX   PubMed=22538806; DOI=10.1073/pnas.1201061109;
RA   Kroger C., Dillon S.C., Cameron A.D., Papenfort K., Sivasankaran S.K.,
RA   Hokamp K., Chao Y., Sittka A., Hebrard M., Handler K., Colgan A.,
RA   Leekitcharoenphon P., Langridge G.C., Lohan A.J., Loftus B., Lucchini S.,
RA   Ussery D.W., Dorman C.J., Thomson N.R., Vogel J., Hinton J.C.;
RT   "The transcriptional landscape and small RNAs of Salmonella enterica
RT   serovar Typhimurium.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:E1277-E1286(2012).
CC   -!- FUNCTION: Involved in the synthesis of the type III secretion system
CC       (T3SS), also called injectisome, which is used to inject bacterial
CC       effector proteins into eukaryotic host cells (By similarity). Pilot
CC       protein that is required for the proper localization of the secretin
CC       InvG/SctC in the outer membrane (By similarity). Necessary for
CC       efficient adherence and entry of these organisms into cultured
CC       epithelial cells (PubMed:8382333). {ECO:0000250|UniProtKB:P0CL43,
CC       ECO:0000269|PubMed:8382333}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000250|UniProtKB:P0CL43}; Lipid-anchor {ECO:0000255|PROSITE-
CC       ProRule:PRU00303}.
CC   -!- SIMILARITY: Belongs to the InvH family. {ECO:0000305}.
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DR   EMBL; Z17242; CAA78942.1; -; Genomic_DNA.
DR   EMBL; FQ312003; CBW18977.1; -; Genomic_DNA.
DR   PIR; S28065; S28065.
DR   RefSeq; WP_000715092.1; NZ_QASL01000017.1.
DR   AlphaFoldDB; E1WAE4; -.
DR   SMR; E1WAE4; -.
DR   EnsemblBacteria; CBW18977; CBW18977; SL1344_2879.
DR   KEGG; sey:SL1344_2879; -.
DR   PATRIC; fig|216597.6.peg.3202; -.
DR   HOGENOM; CLU_123343_0_0_6; -.
DR   OMA; CMSLPYV; -.
DR   BioCyc; SENT216597:SL1344_RS15010-MON; -.
DR   Proteomes; UP000008962; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR006830; InvH.
DR   Pfam; PF04741; InvH; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Lipoprotein; Membrane; Palmitate; Signal; Virulence.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           16..147
FT                   /note="SPI-1 type 3 secretion system pilotin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT                   /id="PRO_0000406077"
FT   LIPID           16
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           16
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ   SEQUENCE   147 AA;  16455 MW;  A02A407F1BC66DCF CRC64;
     MKKFYSCLPV FLLIGCAQVP LPSSVSKPVQ QPGAQKEQLA NANSIDECQS LPYVPSDLAK
     NKSLSNHNAD NSASKNSAIS SSIFCEKYKQ TKEQALTFFQ EHPQYMRSKE DEEQLMTEFK
     KVLLEPGSKN LSIYQTLLAA HERLQAL