ID   SCTL1_SALTS             Reviewed;         226 AA.
AC   E1WAB4; P40823; P58654;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 1.
DT   03-AUG-2022, entry version 44.
DE   RecName: Full=SPI-1 type 3 secretion system stator protein {ECO:0000305};
DE            Short=T3SS-1 stator protein {ECO:0000305};
DE   AltName: Full=Oxygen-regulated invasion protein OrgB;
GN   Name=sctL1 {ECO:0000250|UniProtKB:P0CL45};
GN   Synonyms=orgB {ECO:0000303|PubMed:10816487}; OrderedLocusNames=SL1344_2849;
OS   Salmonella typhimurium (strain SL1344).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=216597;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND INDUCTION.
RC   STRAIN=SL1344;
RX   PubMed=8063389; DOI=10.1128/iai.62.9.3745-3752.1994;
RA   Jones B.D., Falkow S.;
RT   "Identification and characterization of a Salmonella typhimurium oxygen-
RT   regulated gene required for bacterial internalization.";
RL   Infect. Immun. 62:3745-3752(1994).
RN   [2]
RP   SEQUENCE REVISION, AND FUNCTION.
RC   STRAIN=SL1344;
RX   PubMed=10816487; DOI=10.1128/iai.68.6.3368-3376.2000;
RA   Klein J.R., Fahlen T.F., Jones B.D.;
RT   "Transcriptional organization and function of invasion genes within
RT   Salmonella enterica serovar Typhimurium pathogenicity island 1, including
RT   the prgH, prgI, prgJ, prgK, orgA, orgB, and orgC genes.";
RL   Infect. Immun. 68:3368-3376(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SL1344;
RX   PubMed=22538806; DOI=10.1073/pnas.1201061109;
RA   Kroger C., Dillon S.C., Cameron A.D., Papenfort K., Sivasankaran S.K.,
RA   Hokamp K., Chao Y., Sittka A., Hebrard M., Handler K., Colgan A.,
RA   Leekitcharoenphon P., Langridge G.C., Lohan A.J., Loftus B., Lucchini S.,
RA   Ussery D.W., Dorman C.J., Thomson N.R., Vogel J., Hinton J.C.;
RT   "The transcriptional landscape and small RNAs of Salmonella enterica
RT   serovar Typhimurium.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:E1277-E1286(2012).
CC   -!- FUNCTION: Component of the type III secretion system (T3SS), also
CC       called injectisome, which is used to inject bacterial effector proteins
CC       into eukaryotic host cells (By similarity). Acts as a regulator of the
CC       InvC/SctN1 ATPase activity (By similarity). Required for invasion and
CC       secretion (PubMed:10816487). {ECO:0000250|UniProtKB:P0CL45,
CC       ECO:0000250|UniProtKB:Q99PY0, ECO:0000269|PubMed:10816487}.
CC   -!- SUBUNIT: The core secretion machinery of the T3SS is composed of
CC       approximately 20 different proteins, including cytoplasmic components,
CC       a base, an export apparatus and a needle (By similarity). This subunit
CC       is part of the cytosolic complex (By similarity). Interacts directly
CC       with InvC/SctN1 (T3SS-1 ATPase) and SpaO/SctQ (the major sorting
CC       platform component) (By similarity). {ECO:0000250|UniProtKB:P0CL45}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P0CL45}.
CC   -!- INDUCTION: Expression is regulated in an oxygen-dependent manner.
CC       {ECO:0000269|PubMed:8063389}.
CC   -!- CAUTION: Was originally thought to be a longer protein that encodes
CC       what is now known to be OrgA and OrgB. {ECO:0000305|PubMed:10816487,
CC       ECO:0000305|PubMed:8063389}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA72055.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L33855; AAA72055.1; ALT_INIT; Genomic_DNA.
DR   EMBL; FQ312003; CBW18947.1; -; Genomic_DNA.
DR   RefSeq; WP_000916654.1; NZ_QASL01000017.1.
DR   AlphaFoldDB; E1WAB4; -.
DR   SMR; E1WAB4; -.
DR   EnsemblBacteria; CBW18947; CBW18947; SL1344_2849.
DR   KEGG; sey:SL1344_2849; -.
DR   PATRIC; fig|216597.6.peg.3170; -.
DR   HOGENOM; CLU_106719_0_0_6; -.
DR   OMA; DYICEWK; -.
DR   BioCyc; SENT216597:SL1344_RS14855-MON; -.
DR   Proteomes; UP000008962; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Protein transport; Transport; Virulence.
FT   CHAIN           1..226
FT                   /note="SPI-1 type 3 secretion system stator protein"
FT                   /id="PRO_0000406080"
SQ   SEQUENCE   226 AA;  26462 MW;  7414148597F28AA7 CRC64;
     MLKNIPIPSP LSPVEGILIK RKTLERYFSI ERLEQQAHQR AKRILREAEE EAKTLRMYAY
     QEGYEQGMID ALQQVAAYLT DNQTMAWKWM EKIQIYAREL FSAAVDHPET LLTVLDEWLR
     DFDKPEGQLF LTLPVNAKKD HQKLMVLLME NWPGTFNLKY HQEQRFIMSC GDQIAEFSPE
     QFVETAVGVI KHHLDELPQD CRTISDNAIN ALIDEWKTKT QAEVIR