SCTL_YERPE
ID SCTL_YERPE Reviewed; 221 AA.
AC P69976; Q00928; Q663H8;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Type 3 secretion system stator protein {ECO:0000305};
DE Short=T3SS stator protein {ECO:0000305};
DE AltName: Full=Low calcium response locus protein KC;
DE AltName: Full=Yop proteins translocation protein L;
GN Name=sctL {ECO:0000250|UniProtKB:Q01253}; Synonyms=lcrKC, yscL;
GN OrderedLocusNames=YPCD1.61, y5017, y0020, YP_pCD22;
OS Yersinia pestis.
OG Plasmid pCD1.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=KIM5 / Biovar Mediaevalis;
RX PubMed=9746557; DOI=10.1128/iai.66.10.4611-4623.1998;
RA Perry R.D., Straley S.C., Fetherston J.D., Rose D.J., Gregor J.,
RA Blattner F.R.;
RT "DNA sequencing and analysis of the low-Ca2+-response plasmid pCD1 of
RT Yersinia pestis KIM5.";
RL Infect. Immun. 66:4611-4623(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=KIM5 / Biovar Mediaevalis;
RX PubMed=9748454; DOI=10.1128/jb.180.19.5192-5202.1998;
RA Hu P., Elliott J., McCready P., Skowronski E., Garnes J., Kobayashi A.,
RA Brubaker R.R., Garcia E.;
RT "Structural organization of virulence-associated plasmids of Yersinia
RT pestis.";
RL J. Bacteriol. 180:5192-5202(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
RN [5]
RP FUNCTION, SUBUNIT, AND INTERACTION WITH YSCN/SCTN AND YSCQ/SCTQ.
RC STRAIN=KIM5 / Biovar Mediaevalis;
RX PubMed=10779717; DOI=10.1111/j.1574-6968.2000.tb09086.x;
RA Jackson M.W., Plano G.V.;
RT "Interactions between type III secretion apparatus components from Yersinia
RT pestis detected using the yeast two-hybrid system.";
RL FEMS Microbiol. Lett. 186:85-90(2000).
CC -!- FUNCTION: Component of the type III secretion system (T3SS), also
CC called injectisome, which is used to inject bacterial effector proteins
CC into eukaryotic host cells (Probable). Acts as a regulator of the
CC YscN/SctN ATPase activity (By similarity).
CC {ECO:0000250|UniProtKB:Q01253, ECO:0000305|PubMed:10779717}.
CC -!- SUBUNIT: The core secretion machinery of the T3SS is composed of
CC approximately 20 different proteins, including cytoplasmic components,
CC a base, an export apparatus and a needle (By similarity). This subunit
CC is part of the cytosolic complex (Probable). Interacts directly with
CC YscN/SctN (T3SS ATPase) and YscQ/SctQ (the major sorting platform
CC component) (PubMed:10779717). {ECO:0000250|UniProtKB:Q01253,
CC ECO:0000269|PubMed:10779717, ECO:0000305|PubMed:10779717}.
CC -!- INTERACTION:
CC P69976; Q04206: RELA; Xeno; NbExp=2; IntAct=EBI-2846298, EBI-73886;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q01253}.
CC -!- SIMILARITY: Belongs to the SctL stator family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-12 is the initiator.
CC {ECO:0000305}.
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DR EMBL; AF074612; AAC69773.1; -; Genomic_DNA.
DR EMBL; AF053946; AAC62596.1; -; Genomic_DNA.
DR EMBL; AL117189; CAB54938.1; -; Genomic_DNA.
DR EMBL; AE017043; AAS58541.1; -; Genomic_DNA.
DR PIR; T43564; T43564.
DR RefSeq; NP_395195.1; NC_003131.1.
DR RefSeq; NP_857721.1; NC_004836.1.
DR RefSeq; NP_857916.1; NC_004839.1.
DR RefSeq; WP_010981371.1; NZ_WUCL01000050.1.
DR AlphaFoldDB; P69976; -.
DR SMR; P69976; -.
DR IntAct; P69976; 15.
DR MINT; P69976; -.
DR STRING; 214092.5832481; -.
DR DNASU; 1149280; -.
DR EnsemblBacteria; AAS58541; AAS58541; YP_pCD22.
DR GeneID; 66841087; -.
DR KEGG; ype:YPCD1.61; -.
DR KEGG; ypm:YP_pCD22; -.
DR PATRIC; fig|1028802.3.peg.342; -.
DR eggNOG; COG1317; Bacteria.
DR HOGENOM; CLU_062625_2_1_6; -.
DR OMA; CIIETEA; -.
DR Proteomes; UP000000815; Plasmid pCD1.
DR Proteomes; UP000001019; Plasmid pCD1.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0030254; P:protein secretion by the type III secretion system; IEA:InterPro.
DR InterPro; IPR018035; Flagellar_FliH/T3SS_HrpE.
DR InterPro; IPR012842; T3SS_SctL/SctL2.
DR Pfam; PF02108; FliH; 1.
DR TIGRFAMs; TIGR02499; HrpE_YscL_not; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Plasmid; Protein transport; Reference proteome; Transport;
KW Virulence.
FT CHAIN 1..221
FT /note="Type 3 secretion system stator protein"
FT /id="PRO_0000066493"
SQ SEQUENCE 221 AA; 24645 MW; 7181CEEA9D2C54BD CRC64;
MSQTCQTGYA YMQPFVQIIP SNLSLACGLR ILRAEDYQSS LTTEELISAA KQDAEKILAD
AQEVYEQQKQ LGWQAGMDEA RTLQATLIHE TQLQCQQFYR HVEQQMSEVV LLAVRKILND
YDQVAMTLQV VREALALVSN QKQVVVRVNP DQAGAIREQI AKVHKDFPEI SYLEVTADAR
LDQGGCILET EVGIIDASID GQIEALSRAI STTLGQMKVT E
