ID   BETI_PSEAE              Reviewed;         197 AA.
AC   Q9HTJ0;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=HTH-type transcriptional regulator BetI {ECO:0000255|HAMAP-Rule:MF_00768};
GN   Name=betI {ECO:0000255|HAMAP-Rule:MF_00768}; OrderedLocusNames=PA5374;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: Repressor involved in the biosynthesis of the osmoprotectant
CC       glycine betaine. It represses transcription of the choline transporter
CC       BetT and the genes of BetAB involved in the synthesis of glycine
CC       betaine (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via
CC       choline pathway [regulation].
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DR   EMBL; AE004091; AAG08759.1; -; Genomic_DNA.
DR   PIR; G82973; G82973.
DR   RefSeq; NP_254061.1; NC_002516.2.
DR   RefSeq; WP_003096684.1; NZ_QZGE01000031.1.
DR   AlphaFoldDB; Q9HTJ0; -.
DR   SMR; Q9HTJ0; -.
DR   STRING; 287.DR97_2750; -.
DR   PaxDb; Q9HTJ0; -.
DR   PRIDE; Q9HTJ0; -.
DR   DNASU; 881620; -.
DR   EnsemblBacteria; AAG08759; AAG08759; PA5374.
DR   GeneID; 881620; -.
DR   KEGG; pae:PA5374; -.
DR   PATRIC; fig|208964.12.peg.5631; -.
DR   PseudoCAP; PA5374; -.
DR   HOGENOM; CLU_069356_15_4_6; -.
DR   InParanoid; Q9HTJ0; -.
DR   OMA; WLAFYAE; -.
DR   PhylomeDB; Q9HTJ0; -.
DR   BioCyc; PAER208964:G1FZ6-5501-MON; -.
DR   UniPathway; UPA00529; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from choline; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   HAMAP; MF_00768; HTH_type_BetI; 1.
DR   InterPro; IPR039538; BetI_C.
DR   InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   InterPro; IPR017757; Tscrpt_rep_BetI.
DR   Pfam; PF13977; TetR_C_6; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   TIGRFAMs; TIGR03384; betaine_BetI; 1.
DR   PROSITE; PS01081; HTH_TETR_1; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..197
FT                   /note="HTH-type transcriptional regulator BetI"
FT                   /id="PRO_0000070584"
FT   DOMAIN          8..68
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00768"
FT   DNA_BIND        31..50
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00768"
SQ   SEQUENCE   197 AA;  21861 MW;  5BF9AE16F73B96C0 CRC64;
     MPKVGMQPIR RSQLIHATLE AVDQVGMGDA SIALIARLAG VSNGIISHYF QDKNGLLEAT
     MRHLLSALSK AVRERRAALY DDSPRAHLRA IVEGNFDDSQ VNGPAMKTWL AFWATSMHQP
     ALRRLQRVND HRLYSNLCYQ FRRQLSADDA RAAARGLAAL IDGLWLRGAL TGDAFDTDEA
     LNIAYDYLDQ QLAKQSG