SCW11_YEAST
ID SCW11_YEAST Reviewed; 542 AA.
AC P53189; D6VUB0;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Probable family 17 glucosidase SCW11;
DE EC=3.2.1.-;
DE AltName: Full=Soluble cell wall protein 11;
DE Flags: Precursor;
GN Name=SCW11; OrderedLocusNames=YGL028C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169869;
RA Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL Nature 387:81-84(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RC STRAIN=ATCC 96099 / S288c / SEY6210;
RX PubMed=9748433; DOI=10.1128/jb.180.19.5030-5037.1998;
RA Cappellaro C., Mrsa V., Tanner W.;
RT "New potential cell wall glucanases of Saccharomyces cerevisiae and their
RT involvement in mating.";
RL J. Bacteriol. 180:5030-5037(1998).
RN [4]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- FUNCTION: Involved in cell separation. {ECO:0000269|PubMed:9748433}.
CC -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000269|PubMed:9748433}.
CC -!- MISCELLANEOUS: Present with 22600 molecules/cell in log phase SD
CC medium. {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 17 family. {ECO:0000305}.
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DR EMBL; Z72550; CAA96729.1; -; Genomic_DNA.
DR EMBL; BK006941; DAA08071.1; -; Genomic_DNA.
DR PIR; S64030; S64030.
DR RefSeq; NP_011487.3; NM_001180893.3.
DR AlphaFoldDB; P53189; -.
DR SMR; P53189; -.
DR BioGRID; 33219; 28.
DR DIP; DIP-1848N; -.
DR IntAct; P53189; 6.
DR MINT; P53189; -.
DR STRING; 4932.YGL028C; -.
DR CAZy; GH17; Glycoside Hydrolase Family 17.
DR MaxQB; P53189; -.
DR PaxDb; P53189; -.
DR PRIDE; P53189; -.
DR EnsemblFungi; YGL028C_mRNA; YGL028C; YGL028C.
DR GeneID; 852856; -.
DR KEGG; sce:YGL028C; -.
DR SGD; S000002996; SCW11.
DR VEuPathDB; FungiDB:YGL028C; -.
DR eggNOG; ENOG502QS0R; Eukaryota.
DR GeneTree; ENSGT00940000176321; -.
DR HOGENOM; CLU_027285_3_1_1; -.
DR InParanoid; P53189; -.
DR OMA; VVCPYAT; -.
DR BioCyc; YEAST:G3O-30544-MON; -.
DR PRO; PR:P53189; -.
DR Proteomes; UP000002311; Chromosome VII.
DR RNAct; P53189; protein.
DR GO; GO:0071944; C:cell periphery; HDA:SGD.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR GO; GO:0009277; C:fungal-type cell wall; IDA:SGD.
DR GO; GO:0042124; F:1,3-beta-glucanosyltransferase activity; IBA:GO_Central.
DR GO; GO:0042973; F:glucan endo-1,3-beta-D-glucosidase activity; ISS:SGD.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0071555; P:cell wall organization; IBA:GO_Central.
DR InterPro; IPR000490; Glyco_hydro_17.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR SUPFAM; SSF51445; SSF51445; 1.
DR PROSITE; PS00587; GLYCOSYL_HYDROL_F17; 1.
PE 1: Evidence at protein level;
KW Cell wall; Cell wall biogenesis/degradation; Glycosidase; Hydrolase;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..542
FT /note="Probable family 17 glucosidase SCW11"
FT /id="PRO_0000011903"
FT REGION 98..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 138..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 182..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 478
FT /note="Nucleophile"
FT /evidence="ECO:0000250|UniProtKB:O22317"
SQ SEQUENCE 542 AA; 56447 MW; 560CE07CA1669959 CRC64;
MISPISFLSS LLCLTYLTSA LPILPKREVV TRVHTASTTN VVTDFYSTTT EVVIAPTVEF
LISDSVTFTT TLIPQGVNPT AEPTTTITKV LLKKAEMSTS SQPTSTLQPS TIPQSTSSFQ
AESTLQAVST QQTAMSVSAG TSEDVQQLAT TSTSISSSPS PTTTSTSTQN IVSGVGEANV
EGNTQSQHHS YQAAATSTLN QQTSTSIASQ ESTESTNTPT SSSTSSSTSS STSSSTSSST
SSSTSSSTSS STSSSTSSTQ ETAATTSEGS SSSSAAITSS PKAIAYSPYN DDGSCKSADA
VSSDLTLIKS KGISKIRVYG TDCNSFETVQ PAAVKLGIKI NQGLYITSSG VDSIDDSVTT
LIQYGQTNGW DVFDFITVGN EAINNGWCSV SDLISKISSV KSKLSEAGYS GQITTSEPPV
SFENNPDLCK KSDIDFVGIN PHAYFDTSAS AETAGTFVKG QVELIQGVCG TSNVFVTETG
YPSSGIQNGG NIPSTANQIT AVQNILNEMD LDVTILSTYN DYWKAPGDYG IEQSFGVIEY
FP
