ID   SCX18_TITSE             Reviewed;          72 AA.
AC   A0A7S8MU59;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   02-JUN-2021, sequence version 1.
DT   03-AUG-2022, entry version 5.
DE   RecName: Full=Putative sodium channel toxin Ts18 {ECO:0000303|PubMed:33181162};
DE   AltName: Full=Putative alpha-NaTx {ECO:0000303|PubMed:33181162};
DE   AltName: Full=Putative alpha-toxin {ECO:0000303|Ref.1};
DE   AltName: Full=Tityustoxin-18 {ECO:0000305|PubMed:33181162};
DE   Flags: Precursor;
OS   Tityus serrulatus (Brazilian scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Tityus.
OX   NCBI_TaxID=6887;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   DOI=10.4236/ojgen.2012.24027;
RA   Alvarenga E.R., Mendes T.M., Magalhaes B.F., Siqueira F.F., Dantas A.E.,
RA   Barroca T.M., Horta C.C., Kalapothakis E.;
RT   "Transcriptome analysis of the Tityus serrulatus scorpion venom gland.";
RL   O. J. Gen. 2:210-220(2012).
RN   [2] {ECO:0000312|EMBL:QPD99022.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Telson;
RX   PubMed=33181162; DOI=10.1016/j.toxicon.2020.11.001;
RA   Kalapothakis Y., Miranda K., Pereira A.H., Witt A.S.A., Marani C.,
RA   Martins A.P., Leal H.G., Campos-Junior E., Pimenta A.M.C., Borges A.,
RA   Chavez-Olortegui C., Kalapothakis E.;
RT   "Novel components of Tityus serrulatus venom: a transcriptomic approach.";
RL   Toxicon 189:91-104(2021).
CC   -!- FUNCTION: Binds to sodium channels (Nav) and affects the channel
CC       activation process. {ECO:0000250|UniProtKB:Q4LCS8}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:33181162,
CC       ECO:0000305|Ref.1}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:33181162, ECO:0000305|Ref.1}.
CC   -!- SIMILARITY: Belongs to the long (3 C-C) scorpion toxin superfamily.
CC       {ECO:0000305}.
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DR   EMBL; MT081340; QPD99022.1; -; mRNA.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   SUPFAM; SSF57095; SSF57095; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Ion channel impairing toxin; Neurotoxin; Secreted; Signal;
KW   Toxin; Voltage-gated sodium channel impairing toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..72
FT                   /note="Putative sodium channel toxin Ts18"
FT                   /id="PRO_5031515069"
FT   DISULFID        38..61
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01210"
FT   DISULFID        47..66
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01210"
FT   DISULFID        51..68
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01210"
SQ   SEQUENCE   72 AA;  8361 MW;  4C1A27D9EEA422BA CRC64;
     MNFRFPFLLM ITISLIGAVL TFGNDVRPRN QYGNEIFCPH QGFNQKCNAI CKRKKYLLGF
     CDQKTCLCKV RP