ID   SCX23_TITDI             Reviewed;          29 AA.
AC   P60262;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-JAN-2004, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Toxin TdII-3;
DE   Flags: Fragment;
OS   Tityus discrepans (Venezuelan scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Tityus.
OX   NCBI_TaxID=57059;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Venom;
RX   PubMed=8783453; DOI=10.1016/0041-0101(95)00156-5;
RA   D'Suze G., Corona F., Possani L.D., Sevcik C.;
RT   "High performance liquid chromatography purification and amino acid
RT   sequence of toxins from the muscarinic fraction of Tityus discrepans
RT   scorpion venom.";
RL   Toxicon 34:591-598(1996).
CC   -!- FUNCTION: Binds voltage-independently to sodium channels (Nav) and
CC       shifts the voltage of activation toward more negative potentials (By
CC       similarity). This toxin is active against mammals and also affects
CC       neuromuscular preparations of frog. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to
CC       antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the long (4 C-C) scorpion toxin superfamily.
CC       Sodium channel inhibitor family. Beta subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P60262; -.
DR   SMR; P60262; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0017080; F:sodium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.30.10; -; 1.
DR   InterPro; IPR044062; LCN-type_CS_alpha_beta_dom.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   SUPFAM; SSF57095; SSF57095; 1.
DR   PROSITE; PS51863; LCN_CSAB; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Ion channel impairing toxin; Neurotoxin;
KW   Secreted; Toxin; Voltage-gated sodium channel impairing toxin.
FT   CHAIN           1..>29
FT                   /note="Toxin TdII-3"
FT                   /id="PRO_0000066822"
FT   DOMAIN          1..>29
FT                   /note="LCN-type CS-alpha/beta"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01210"
FT   NON_TER         29
SQ   SEQUENCE   29 AA;  3185 MW;  B0FED163CF221C12 CRC64;
     KDGYLVGTDG CKYGCFTRPG HFCANEECL