ID   ABDA_ARTSF              Reviewed;         139 AA.
AC   Q05007;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Homeobox protein abdominal-A homolog;
DE   Flags: Fragment;
GN   Name=ABDA;
OS   Artemia franciscana (Brine shrimp) (Artemia sanfranciscana).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC   Anostraca; Artemiidae; Artemia.
OX   NCBI_TaxID=6661;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15335797; DOI=10.1016/0960-9822(93)90158-k;
RA   Averof M., Akam M.;
RT   "HOM/Hox genes of Artemia: implications for the origin of insect and
RT   crustacea body plans.";
RL   Curr. Biol. 3:73-78(1993).
CC   -!- FUNCTION: Required for segmental identity of the second through eighth
CC       abdominal segments. Once a pattern of abdA expression is turned on in a
CC       given parasegment, it remains on the more posterior parasegment, so
CC       that the complex pattern of expression is built up in the successive
CC       parasegments. The abdA product appears to repress expression of Ubx
CC       whenever they appear in the same cell, but abdA is repressed by AbdB
CC       only in the eight and ninth abdominal segments.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; X70076; CAA49681.1; -; Genomic_DNA.
DR   PIR; S31810; S31810.
DR   AlphaFoldDB; Q05007; -.
DR   SMR; Q05007; -.
DR   PRIDE; Q05007; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR022132; Abdominal-A.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF12407; Abdominal-A; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus.
FT   CHAIN           <1..139
FT                   /note="Homeobox protein abdominal-A homolog"
FT                   /id="PRO_0000200255"
FT   DNA_BIND        6..65
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          73..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          119..139
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        73..91
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   139 AA;  16311 MW;  7DF831839E298E32 CRC64;
     PNGCPRRRGR QTYTRYQTLE LEKEFHFNHY LTRRRRIEIA HALCLTERQI KIWFQNRRMK
     LKKELRAVKE INEQARKDRE EQEHKIRSSS SDDGSIGKGV GIPLDASLLK SNDSQSVSLN
     HLTHKSPDGM MDKTPKSII