ID   SCX29_CENNO             Reviewed;          27 AA.
AC   A0A5H1ZR48; C0HLK4;
DT   12-AUG-2020, integrated into UniProtKB/Swiss-Prot.
DT   11-DEC-2019, sequence version 1.
DT   25-MAY-2022, entry version 11.
DE   RecName: Full=Peptide Cn29 {ECO:0000303|PubMed:31226259};
OS   Centruroides noxius (Mexican scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Centruroides.
OX   NCBI_TaxID=6878 {ECO:0000303|PubMed:31226259};
RN   [1] {ECO:0000305}
RP   STRUCTURE BY NMR, PROTEIN SEQUENCE, SYNTHESIS, SUBCELLULAR LOCATION, MASS
RP   SPECTROMETRY, AND DISULFIDE BOND.
RC   TISSUE=Venom {ECO:0000303|PubMed:31226259};
RX   PubMed=31226259; DOI=10.1016/j.toxicon.2019.06.013;
RA   Gurrola G.B., Guijarro J.I., Delepierre M., Mendoza R.L.L., Cid-Uribe J.I.,
RA   Coronas F.V., Possani L.D.;
RT   "Cn29, a novel orphan peptide found in the venom of the scorpion
RT   Centruroides noxius: Structure and function.";
RL   Toxicon 167:184-191(2019).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:31226259}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:31226259}.
CC   -!- MASS SPECTROMETRY: Mass=2820.60; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:31226259};
CC   -!- MISCELLANEOUS: Does not show any toxicity upon intracerebroventricular
CC       injection into mice and abdominal injection into crickets. Has no
CC       effect on human voltage-gated sodium (Nav1.5/SCN5A, Nav1.6/SCN8A and
CC       Nav1.7/SCN9A) and potassium (Kv1.1/KCNA1 and Kv1.4/KCNA4) currents (in
CC       vitro). {ECO:0000269|PubMed:31226259}.
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DR   PDB; 6NW8; NMR; -; A=1-27.
DR   PDBsum; 6NW8; -.
DR   AlphaFoldDB; A0A5H1ZR48; -.
DR   SMR; A0A5H1ZR48; -.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
PE   1: Evidence at protein level;
KW   3D-structure; Direct protein sequencing; Disulfide bond; Secreted.
FT   CHAIN           1..27
FT                   /note="Peptide Cn29"
FT                   /id="PRO_0000450602"
FT   DISULFID        2..23
FT                   /evidence="ECO:0000269|PubMed:31226259,
FT                   ECO:0007744|PDB:6NW8"
FT   DISULFID        5..18
FT                   /evidence="ECO:0000269|PubMed:31226259,
FT                   ECO:0007744|PDB:6NW8"
FT   DISULFID        12..25
FT                   /evidence="ECO:0000269|PubMed:31226259,
FT                   ECO:0007744|PDB:6NW8"
FT   STRAND          3..6
FT                   /evidence="ECO:0007829|PDB:6NW8"
FT   HELIX           10..14
FT                   /evidence="ECO:0007829|PDB:6NW8"
FT   STRAND          15..19
FT                   /evidence="ECO:0007829|PDB:6NW8"
FT   STRAND          22..24
FT                   /evidence="ECO:0007829|PDB:6NW8"
SQ   SEQUENCE   27 AA;  2827 MW;  385E9B74EEB20884 CRC64;
     LCLSCRGGDY DCRVKGTCEN GKCVCGS